FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294842919> ?p ?o ?g. }

• W4294842919 endingPage "1541" @default.
• W4294842919 startingPage "1534" @default.
• W4294842919 abstract "The polyadenylation signal (PAS) is a key sequence element for 3'-end cleavage and polyadenylation of messenger RNA precursors (pre-mRNAs). This hexanucleotide motif is recognized by the mammalian polyadenylation specificity factor (mPSF), consisting of CPSF160, WDR33, CPSF30, and Fip1 subunits. Recent studies have revealed how the AAUAAA PAS, the most frequently observed PAS, is recognized by mPSF. We report here the structure of human mPSF in complex with the AUUAAA PAS, the second most frequently identified PAS. Conformational differences are observed for the A1 and U2 nucleotides in AUUAAA compared to the A1 and A2 nucleotides in AAUAAA, while the binding modes of the remaining 4 nt are essentially identical. The 5' phosphate of U2 moves by 2.6 Å and the U2 base is placed near the six-membered ring of A2 in AAUAAA, where it makes two hydrogen bonds with zinc finger 2 (ZF2) of CPSF30, which undergoes conformational changes as well. We also attempted to determine the binding modes of two rare PAS hexamers, AAGAAA and GAUAAA, but did not observe the RNA in the cryo-electron microscopy density. The residues in CPSF30 (ZF2 and ZF3) and WDR33 that recognize PAS are disordered in these two structures." @default.
• W4294842919 created "2022-09-07" @default.
• W4294842919 creator A5004904484 @default.
• W4294842919 creator A5032161415 @default.
• W4294842919 creator A5063964437 @default.
• W4294842919 creator A5088533848 @default.
• W4294842919 date "2022-09-06" @default.
• W4294842919 modified "2023-09-29" @default.
• W4294842919 title "Molecular basis for the recognition of the AUUAAA polyadenylation signal by mPSF" @default.
• W4294842919 cites W1545350340 @default.
• W4294842919 cites W1966320967 @default.
• W4294842919 cites W1973159925 @default.
• W4294842919 cites W1991230146 @default.
• W4294842919 cites W2010088308 @default.
• W4294842919 cites W2010131411 @default.
• W4294842919 cites W2027784918 @default.
• W4294842919 cites W2043111511 @default.
• W4294842919 cites W2047935781 @default.
• W4294842919 cites W2056608604 @default.
• W4294842919 cites W2064723275 @default.
• W4294842919 cites W2079591756 @default.
• W4294842919 cites W2105545925 @default.
• W4294842919 cites W2105879579 @default.
• W4294842919 cites W2109184569 @default.
• W4294842919 cites W2115328666 @default.
• W4294842919 cites W2132629607 @default.
• W4294842919 cites W2137583334 @default.
• W4294842919 cites W2144081223 @default.
• W4294842919 cites W2151562469 @default.
• W4294842919 cites W2166494447 @default.
• W4294842919 cites W2180502603 @default.
• W4294842919 cites W2461965332 @default.
• W4294842919 cites W2525507785 @default.
• W4294842919 cites W2587625522 @default.
• W4294842919 cites W2765231623 @default.
• W4294842919 cites W2766001310 @default.
• W4294842919 cites W2778462241 @default.
• W4294842919 cites W2785666191 @default.
• W4294842919 cites W2899714098 @default.
• W4294842919 cites W2970997250 @default.
• W4294842919 cites W2991942286 @default.
• W4294842919 cites W3033684140 @default.
• W4294842919 doi "https://doi.org/10.1261/rna.079322.122" @default.
• W4294842919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36130077" @default.
• W4294842919 hasPublicationYear "2022" @default.
• W4294842919 type Work @default.
• W4294842919 citedByCount "1" @default.
• W4294842919 countsByYear W42948429192023 @default.
• W4294842919 crossrefType "journal-article" @default.
• W4294842919 hasAuthorship W4294842919A5004904484 @default.
• W4294842919 hasAuthorship W4294842919A5032161415 @default.
• W4294842919 hasAuthorship W4294842919A5063964437 @default.
• W4294842919 hasAuthorship W4294842919A5088533848 @default.
• W4294842919 hasConcept C104317684 @default.
• W4294842919 hasConcept C12554922 @default.
• W4294842919 hasConcept C142575336 @default.
• W4294842919 hasConcept C151730666 @default.
• W4294842919 hasConcept C175156509 @default.
• W4294842919 hasConcept C22232683 @default.
• W4294842919 hasConcept C24284526 @default.
• W4294842919 hasConcept C41282012 @default.
• W4294842919 hasConcept C43369102 @default.
• W4294842919 hasConcept C512185932 @default.
• W4294842919 hasConcept C55493867 @default.
• W4294842919 hasConcept C62531158 @default.
• W4294842919 hasConcept C67705224 @default.
• W4294842919 hasConcept C86339819 @default.
• W4294842919 hasConcept C86803240 @default.
• W4294842919 hasConcept C95444343 @default.
• W4294842919 hasConceptScore W4294842919C104317684 @default.
• W4294842919 hasConceptScore W4294842919C12554922 @default.
• W4294842919 hasConceptScore W4294842919C142575336 @default.
• W4294842919 hasConceptScore W4294842919C151730666 @default.
• W4294842919 hasConceptScore W4294842919C175156509 @default.
• W4294842919 hasConceptScore W4294842919C22232683 @default.
• W4294842919 hasConceptScore W4294842919C24284526 @default.
• W4294842919 hasConceptScore W4294842919C41282012 @default.
• W4294842919 hasConceptScore W4294842919C43369102 @default.
• W4294842919 hasConceptScore W4294842919C512185932 @default.
• W4294842919 hasConceptScore W4294842919C55493867 @default.
• W4294842919 hasConceptScore W4294842919C62531158 @default.
• W4294842919 hasConceptScore W4294842919C67705224 @default.
• W4294842919 hasConceptScore W4294842919C86339819 @default.
• W4294842919 hasConceptScore W4294842919C86803240 @default.
• W4294842919 hasConceptScore W4294842919C95444343 @default.
• W4294842919 hasFunder F4320332161 @default.
• W4294842919 hasIssue "11" @default.
• W4294842919 hasLocation W42948429191 @default.
• W4294842919 hasLocation W42948429192 @default.
• W4294842919 hasOpenAccess W4294842919 @default.
• W4294842919 hasPrimaryLocation W42948429191 @default.
• W4294842919 hasRelatedWork W1997569498 @default.
• W4294842919 hasRelatedWork W2003805923 @default.
• W4294842919 hasRelatedWork W2009700107 @default.
• W4294842919 hasRelatedWork W2062788610 @default.
• W4294842919 hasRelatedWork W2079155564 @default.
• W4294842919 hasRelatedWork W2109684789 @default.
• W4294842919 hasRelatedWork W2132373170 @default.

• next