Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294869638> ?p ?o ?g. }
- W4294869638 abstract "Vanillic acid, a phenolic compound mainly obtained from the foot of Picrorhiza scrophulariiflora Pennell, has been demonstrated to possess a cardiovascular-protective effect in previous studies. However, there is lack of research on vanillic acid protecting cardiomyocytes from oxidative stress injury by mediating mitophagy. In the present study, oxidative stress injury in the H9c2 cell line was induced by H 2 O 2 . Our results confirmed that vanillic acid mitigated apoptosis and injury triggered by oxidative stress, evidenced by the decline in production of reactive oxygen species and malondialdehyde and level of lactate dehydrogenase and the increase of superoxide dismutase and glutathione. The use of vanillic acid could also improve the polarization of mitochondrial membrane potential and decrease the cellular calcium level. After treatment by vanillic acid, impaired autophagy flux and mitophagy were improved, and the length of mitochondria was restored. Vanillic acid increased the expression of PINK1, Parkin, Mfn2, and the ratio of LC3-II/LC3-I and decreased the expression of p62. But, under the intervention of mitophagy inhibitor 3-MA, vanillic acid could not change the expression of PINK1/Parkin/Mfn2 and downstream genes to affect cell autophagy, mitophagy, and mitochondrial function. Our findings suggested that vanillic acid activated mitophagy to improve mitochondrial function, in which the PINK1/Parkin/Mfn2 pathway could be the potential regulatory mechanism." @default.
- W4294869638 created "2022-09-07" @default.
- W4294869638 creator A5013665491 @default.
- W4294869638 creator A5017490755 @default.
- W4294869638 creator A5039524325 @default.
- W4294869638 creator A5044905503 @default.
- W4294869638 creator A5047192560 @default.
- W4294869638 creator A5071960955 @default.
- W4294869638 creator A5073046343 @default.
- W4294869638 creator A5081923965 @default.
- W4294869638 creator A5091365015 @default.
- W4294869638 date "2022-09-07" @default.
- W4294869638 modified "2023-10-15" @default.
- W4294869638 title "Vanillic acid attenuates H2O2-induced injury in H9c2 cells by regulating mitophagy via the PINK1/Parkin/Mfn2 signaling pathway" @default.
- W4294869638 cites W1940802192 @default.
- W4294869638 cites W1973926398 @default.
- W4294869638 cites W1992952078 @default.
- W4294869638 cites W2012050664 @default.
- W4294869638 cites W2013133976 @default.
- W4294869638 cites W2013642338 @default.
- W4294869638 cites W2014058980 @default.
- W4294869638 cites W2034063092 @default.
- W4294869638 cites W2035716371 @default.
- W4294869638 cites W2049016912 @default.
- W4294869638 cites W2052468549 @default.
- W4294869638 cites W2058074871 @default.
- W4294869638 cites W2076619948 @default.
- W4294869638 cites W2086557228 @default.
- W4294869638 cites W2097704104 @default.
- W4294869638 cites W2158363851 @default.
- W4294869638 cites W2568510753 @default.
- W4294869638 cites W2621728938 @default.
- W4294869638 cites W2752326209 @default.
- W4294869638 cites W2773927148 @default.
- W4294869638 cites W2775542957 @default.
- W4294869638 cites W2805968246 @default.
- W4294869638 cites W2900734125 @default.
- W4294869638 cites W2913605258 @default.
- W4294869638 cites W2946684713 @default.
- W4294869638 cites W2950260902 @default.
- W4294869638 cites W2957095132 @default.
- W4294869638 cites W2992413943 @default.
- W4294869638 cites W2993223434 @default.
- W4294869638 cites W3006825624 @default.
- W4294869638 cites W3007891666 @default.
- W4294869638 cites W3011459566 @default.
- W4294869638 cites W3015135577 @default.
- W4294869638 cites W3093012776 @default.
- W4294869638 cites W3153966061 @default.
- W4294869638 cites W4212895951 @default.
- W4294869638 doi "https://doi.org/10.3389/fphar.2022.976156" @default.
- W4294869638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36160415" @default.
- W4294869638 hasPublicationYear "2022" @default.
- W4294869638 type Work @default.
- W4294869638 citedByCount "1" @default.
- W4294869638 countsByYear W42948696382023 @default.
- W4294869638 crossrefType "journal-article" @default.
- W4294869638 hasAuthorship W4294869638A5013665491 @default.
- W4294869638 hasAuthorship W4294869638A5017490755 @default.
- W4294869638 hasAuthorship W4294869638A5039524325 @default.
- W4294869638 hasAuthorship W4294869638A5044905503 @default.
- W4294869638 hasAuthorship W4294869638A5047192560 @default.
- W4294869638 hasAuthorship W4294869638A5071960955 @default.
- W4294869638 hasAuthorship W4294869638A5073046343 @default.
- W4294869638 hasAuthorship W4294869638A5081923965 @default.
- W4294869638 hasAuthorship W4294869638A5091365015 @default.
- W4294869638 hasBestOaLocation W42948696381 @default.
- W4294869638 hasConcept C104317684 @default.
- W4294869638 hasConcept C126322002 @default.
- W4294869638 hasConcept C163950672 @default.
- W4294869638 hasConcept C178790620 @default.
- W4294869638 hasConcept C185592680 @default.
- W4294869638 hasConcept C190283241 @default.
- W4294869638 hasConcept C203522944 @default.
- W4294869638 hasConcept C24586158 @default.
- W4294869638 hasConcept C2776151105 @default.
- W4294869638 hasConcept C2776549161 @default.
- W4294869638 hasConcept C2776804853 @default.
- W4294869638 hasConcept C2777092462 @default.
- W4294869638 hasConcept C2777668072 @default.
- W4294869638 hasConcept C2779134260 @default.
- W4294869638 hasConcept C2779324830 @default.
- W4294869638 hasConcept C2779734285 @default.
- W4294869638 hasConcept C28859421 @default.
- W4294869638 hasConcept C55493867 @default.
- W4294869638 hasConcept C71924100 @default.
- W4294869638 hasConcept C86803240 @default.
- W4294869638 hasConcept C95444343 @default.
- W4294869638 hasConcept C98274493 @default.
- W4294869638 hasConceptScore W4294869638C104317684 @default.
- W4294869638 hasConceptScore W4294869638C126322002 @default.
- W4294869638 hasConceptScore W4294869638C163950672 @default.
- W4294869638 hasConceptScore W4294869638C178790620 @default.
- W4294869638 hasConceptScore W4294869638C185592680 @default.
- W4294869638 hasConceptScore W4294869638C190283241 @default.
- W4294869638 hasConceptScore W4294869638C203522944 @default.
- W4294869638 hasConceptScore W4294869638C24586158 @default.
- W4294869638 hasConceptScore W4294869638C2776151105 @default.
- W4294869638 hasConceptScore W4294869638C2776549161 @default.
- W4294869638 hasConceptScore W4294869638C2776804853 @default.