Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294884856> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W4294884856 endingPage "193" @default.
- W4294884856 startingPage "187" @default.
- W4294884856 abstract "Programmed cell death ligand 1 (PD-L1) expression plays an important role in selecting patients with hepatocellular carcinoma who will benefit from anti-programmed cell death 1 (PD-1)/PD-L1 monotherapy and directing those with lower levels to alternative treatments. In total, 156 hepatocellular carcinoma tumors were stained with three PD-L1 immunohistochemistry assays (SP142, 28-8, and E1L3N). Two junior pathologists and one senior pathologist evaluated the pathological slides and recorded the percentages of tumor and immune cells stained at any intensity. Analytical comparisons demonstrated that the anti-PD-L1 assay SP142 is a significantly stronger reagent that stains a higher percent of both tumor and immune cells, while 28-8 and E1L3N behave similarly to each other. The correlation coefficients of the three assays ranged from 0.77 to 0.92 for tumor cells and from 0.66 to 0.75 for immune cells. Next, 1% and 5% tumor cell staining cutoffs were designated using various combinations of assays and cutoffs. Across all three reagents, 14 samples showed concordance above the 5% threshold, eight showed concordance within the range of 1% to 5% interval, and 93 showed concordance below the 1% threshold. The remaining 41 samples showed a combination of discordant results across all three reagents. High PD-L1 expression in tumor and immune cells tended to not be recurrent. The anti-PD-L1 assays 28-8 and E1L3N were closely aligned with regard to staining tumor and immune cells, whereas SP142 showed higher percentages of staining for both cell types. All three assays indicated greater variability in immune cell staining than in tumor cells." @default.
- W4294884856 created "2022-09-07" @default.
- W4294884856 creator A5035913220 @default.
- W4294884856 creator A5048875338 @default.
- W4294884856 creator A5079269690 @default.
- W4294884856 creator A5089515440 @default.
- W4294884856 date "2022-09-01" @default.
- W4294884856 modified "2023-09-27" @default.
- W4294884856 title "A retrospective study of PD-L1 immunohistochemistry for hepatocellular carcinoma" @default.
- W4294884856 cites W2030612376 @default.
- W4294884856 cites W2104347254 @default.
- W4294884856 cites W2494958745 @default.
- W4294884856 cites W2499029168 @default.
- W4294884856 cites W2557730509 @default.
- W4294884856 cites W2606367731 @default.
- W4294884856 cites W2742341423 @default.
- W4294884856 cites W2742359504 @default.
- W4294884856 cites W2743614427 @default.
- W4294884856 cites W2754223242 @default.
- W4294884856 cites W2775098059 @default.
- W4294884856 cites W2794306956 @default.
- W4294884856 cites W2799372507 @default.
- W4294884856 cites W2799709946 @default.
- W4294884856 cites W2804957255 @default.
- W4294884856 cites W2805592007 @default.
- W4294884856 cites W2889646458 @default.
- W4294884856 cites W2891760302 @default.
- W4294884856 cites W2944373530 @default.
- W4294884856 cites W2948172856 @default.
- W4294884856 cites W2965019135 @default.
- W4294884856 cites W2998980069 @default.
- W4294884856 cites W3021888588 @default.
- W4294884856 cites W3044366349 @default.
- W4294884856 cites W3082280013 @default.
- W4294884856 cites W3090386613 @default.
- W4294884856 cites W3106496576 @default.
- W4294884856 cites W3110101623 @default.
- W4294884856 cites W3117348379 @default.
- W4294884856 cites W3121807241 @default.
- W4294884856 cites W3134166599 @default.
- W4294884856 doi "https://doi.org/10.1016/j.iliver.2022.08.005" @default.
- W4294884856 hasPublicationYear "2022" @default.
- W4294884856 type Work @default.
- W4294884856 citedByCount "0" @default.
- W4294884856 crossrefType "journal-article" @default.
- W4294884856 hasAuthorship W4294884856A5035913220 @default.
- W4294884856 hasAuthorship W4294884856A5048875338 @default.
- W4294884856 hasAuthorship W4294884856A5079269690 @default.
- W4294884856 hasAuthorship W4294884856A5089515440 @default.
- W4294884856 hasBestOaLocation W42948848561 @default.
- W4294884856 hasConcept C126322002 @default.
- W4294884856 hasConcept C142724271 @default.
- W4294884856 hasConcept C160798450 @default.
- W4294884856 hasConcept C203014093 @default.
- W4294884856 hasConcept C204232928 @default.
- W4294884856 hasConcept C2777546739 @default.
- W4294884856 hasConcept C2777701055 @default.
- W4294884856 hasConcept C2778019345 @default.
- W4294884856 hasConcept C2781053074 @default.
- W4294884856 hasConcept C502942594 @default.
- W4294884856 hasConcept C71924100 @default.
- W4294884856 hasConcept C74864618 @default.
- W4294884856 hasConcept C86803240 @default.
- W4294884856 hasConcept C8891405 @default.
- W4294884856 hasConceptScore W4294884856C126322002 @default.
- W4294884856 hasConceptScore W4294884856C142724271 @default.
- W4294884856 hasConceptScore W4294884856C160798450 @default.
- W4294884856 hasConceptScore W4294884856C203014093 @default.
- W4294884856 hasConceptScore W4294884856C204232928 @default.
- W4294884856 hasConceptScore W4294884856C2777546739 @default.
- W4294884856 hasConceptScore W4294884856C2777701055 @default.
- W4294884856 hasConceptScore W4294884856C2778019345 @default.
- W4294884856 hasConceptScore W4294884856C2781053074 @default.
- W4294884856 hasConceptScore W4294884856C502942594 @default.
- W4294884856 hasConceptScore W4294884856C71924100 @default.
- W4294884856 hasConceptScore W4294884856C74864618 @default.
- W4294884856 hasConceptScore W4294884856C86803240 @default.
- W4294884856 hasConceptScore W4294884856C8891405 @default.
- W4294884856 hasIssue "3" @default.
- W4294884856 hasLocation W42948848561 @default.
- W4294884856 hasOpenAccess W4294884856 @default.
- W4294884856 hasPrimaryLocation W42948848561 @default.
- W4294884856 hasRelatedWork W1514899824 @default.
- W4294884856 hasRelatedWork W1992481203 @default.
- W4294884856 hasRelatedWork W1993946980 @default.
- W4294884856 hasRelatedWork W2013745628 @default.
- W4294884856 hasRelatedWork W2035464821 @default.
- W4294884856 hasRelatedWork W2040976599 @default.
- W4294884856 hasRelatedWork W2052513855 @default.
- W4294884856 hasRelatedWork W2232352716 @default.
- W4294884856 hasRelatedWork W2429210815 @default.
- W4294884856 hasRelatedWork W50742768 @default.
- W4294884856 hasVolume "1" @default.
- W4294884856 isParatext "false" @default.
- W4294884856 isRetracted "false" @default.
- W4294884856 workType "article" @default.