Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294904771> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4294904771 abstract "Mycobacterium abscessusis an opportunistic human pathogen of increasing concern, due to its ability to cause aggressive pulmonary infections (especially in cystic fibrosis patients), as well as skin and soft tissue infections. M. abscessus is intrinsically drug resistant and treatment regimens are lengthy, consisting of multiple antibiotics with severe side effects and poor patient success rates. New and novel strategies are urgently required to combat these infections. One such strategy thus far overlooked for mycobacteria is manuka honey. For millennia manuka honey has been shown to have wide ranging medicinal properties, which have more recently been identified for its broad spectrum of antimicrobial activity. Here we demonstrate that manuka honey can be used to inhibit M. abscessus and a variety of drug resistant clinical isolates in vitro. We also demonstrate using a microbroth dilution checkerboard assay that manuka honey works synergistically with amikacin, which is one of the current front line antibiotics used for treatment of M. abscessus infections. This was further validated using an in vitro inhalation model, where we showed that with the addition of manuka honey, the amikacin dosage can be lowered whilst increasing its efficacy. These findings demonstrate the utility of manuka honey for incorporation into nebulised antibiotic treatment for respiratory infections, in particular M. abscessus. These results pave the way for a change of strategy for M. abscessus management, offering new therapeutic options for this deadly infection." @default.
- W4294904771 created "2022-09-07" @default.
- W4294904771 creator A5003265664 @default.
- W4294904771 creator A5012140483 @default.
- W4294904771 creator A5069306943 @default.
- W4294904771 date "2022-09-07" @default.
- W4294904771 modified "2023-09-28" @default.
- W4294904771 title "In vitro synergy between manuka honey and amikacin against Mycobacterium abscessus complex shows potential for nebulisation therapy" @default.
- W4294904771 cites W1975224140 @default.
- W4294904771 cites W1992468719 @default.
- W4294904771 cites W2020473718 @default.
- W4294904771 cites W2021463425 @default.
- W4294904771 cites W2050091252 @default.
- W4294904771 cites W2066452267 @default.
- W4294904771 cites W2095656393 @default.
- W4294904771 cites W2100083289 @default.
- W4294904771 cites W2118287340 @default.
- W4294904771 cites W2122539898 @default.
- W4294904771 cites W2145496052 @default.
- W4294904771 cites W2177577861 @default.
- W4294904771 cites W2322634439 @default.
- W4294904771 cites W2340254326 @default.
- W4294904771 cites W2400048388 @default.
- W4294904771 cites W2568318866 @default.
- W4294904771 cites W2765727761 @default.
- W4294904771 cites W2794906440 @default.
- W4294904771 cites W2889161855 @default.
- W4294904771 cites W2897003522 @default.
- W4294904771 cites W2912845399 @default.
- W4294904771 cites W2925529146 @default.
- W4294904771 cites W2991356028 @default.
- W4294904771 cites W2992427113 @default.
- W4294904771 cites W3034040206 @default.
- W4294904771 cites W3091340828 @default.
- W4294904771 cites W3095156938 @default.
- W4294904771 cites W3161302168 @default.
- W4294904771 doi "https://doi.org/10.1099/mic.0.001237" @default.
- W4294904771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36069786" @default.
- W4294904771 hasPublicationYear "2022" @default.
- W4294904771 type Work @default.
- W4294904771 citedByCount "2" @default.
- W4294904771 countsByYear W42949047712022 @default.
- W4294904771 crossrefType "journal-article" @default.
- W4294904771 hasAuthorship W4294904771A5003265664 @default.
- W4294904771 hasAuthorship W4294904771A5012140483 @default.
- W4294904771 hasAuthorship W4294904771A5069306943 @default.
- W4294904771 hasBestOaLocation W42949047712 @default.
- W4294904771 hasConcept C126322002 @default.
- W4294904771 hasConcept C142724271 @default.
- W4294904771 hasConcept C2776111603 @default.
- W4294904771 hasConcept C2776938444 @default.
- W4294904771 hasConcept C2777427914 @default.
- W4294904771 hasConcept C2777637488 @default.
- W4294904771 hasConcept C2780374374 @default.
- W4294904771 hasConcept C2781069245 @default.
- W4294904771 hasConcept C2910659018 @default.
- W4294904771 hasConcept C4937899 @default.
- W4294904771 hasConcept C501593827 @default.
- W4294904771 hasConcept C523546767 @default.
- W4294904771 hasConcept C54355233 @default.
- W4294904771 hasConcept C71924100 @default.
- W4294904771 hasConcept C86803240 @default.
- W4294904771 hasConcept C89423630 @default.
- W4294904771 hasConceptScore W4294904771C126322002 @default.
- W4294904771 hasConceptScore W4294904771C142724271 @default.
- W4294904771 hasConceptScore W4294904771C2776111603 @default.
- W4294904771 hasConceptScore W4294904771C2776938444 @default.
- W4294904771 hasConceptScore W4294904771C2777427914 @default.
- W4294904771 hasConceptScore W4294904771C2777637488 @default.
- W4294904771 hasConceptScore W4294904771C2780374374 @default.
- W4294904771 hasConceptScore W4294904771C2781069245 @default.
- W4294904771 hasConceptScore W4294904771C2910659018 @default.
- W4294904771 hasConceptScore W4294904771C4937899 @default.
- W4294904771 hasConceptScore W4294904771C501593827 @default.
- W4294904771 hasConceptScore W4294904771C523546767 @default.
- W4294904771 hasConceptScore W4294904771C54355233 @default.
- W4294904771 hasConceptScore W4294904771C71924100 @default.
- W4294904771 hasConceptScore W4294904771C86803240 @default.
- W4294904771 hasConceptScore W4294904771C89423630 @default.
- W4294904771 hasIssue "9" @default.
- W4294904771 hasLocation W42949047711 @default.
- W4294904771 hasLocation W42949047712 @default.
- W4294904771 hasLocation W42949047713 @default.
- W4294904771 hasOpenAccess W4294904771 @default.
- W4294904771 hasPrimaryLocation W42949047711 @default.
- W4294904771 hasRelatedWork W1953284759 @default.
- W4294904771 hasRelatedWork W1974640937 @default.
- W4294904771 hasRelatedWork W1991671695 @default.
- W4294904771 hasRelatedWork W2038138310 @default.
- W4294904771 hasRelatedWork W2038672409 @default.
- W4294904771 hasRelatedWork W2166197999 @default.
- W4294904771 hasRelatedWork W2429994691 @default.
- W4294904771 hasRelatedWork W2801526422 @default.
- W4294904771 hasRelatedWork W2890118735 @default.
- W4294904771 hasRelatedWork W4294904771 @default.
- W4294904771 hasVolume "168" @default.
- W4294904771 isParatext "false" @default.
- W4294904771 isRetracted "false" @default.
- W4294904771 workType "article" @default.