Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294917892> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4294917892 endingPage "339" @default.
- W4294917892 startingPage "332" @default.
- W4294917892 abstract "Introduction: Incidentally detected malignancies in lung explants portend risk of early cancer recurrence and metastases with posttransplant immunosuppression. We present a series of lung transplant recipients with previously unverified malignancies in native lung explants. Design: We reviewed the histopathology, radiographic imaging, and management of lung explant malignancies at our institution over 10 years (2011-2020). Endpoints were survival and allograft rejection. Results: An explant malignancy was found in 1.3% (11/855) of lung transplant recipients (6 [55%] men; median age 68 years; 6 [55%] ex-smokers [median pack-years, 25]). Nine (82%) were adenocarcinoma, 1 (9%) was squamous cell carcinoma (SCC), and 1 (9%) was follicular lymphoma. Three patients (27%) had multifocal involvement (≥3 lobes), 4 (36%) had nodal involvement, and the median (range) tumor size was 2.7 (0.4-19) cm. The median interval between last imaging and transplant was 58 (29-144) days. Mycophenolate mofetil was discontinued or reduced in all; everolimus was used in 2 patients, and cisplatin-pemetrexed chemotherapy was used in 2 patients. The prevalence of acute cellular rejection and chronic rejection was 27% and 9%, respectively. Lung recipients with cancer had significantly lower survival than those without (36.4% vs 67.3%, p = 0.002); median survival was 27 (17, 65) months in 4 recipients who were alive and cancer-free at the end of the study period. Conclusions: Unidentified malignancies, commonly adenocarcinoma, can be detected in explanted native lungs. Pneumonectomy may be curative in SCC, lymphoproliferative disorders, and stage I adenocarcinoma. Modulating immunosuppression to prevent allograft rejection and tumor proliferation is warranted." @default.
- W4294917892 created "2022-09-08" @default.
- W4294917892 creator A5002289410 @default.
- W4294917892 creator A5002309691 @default.
- W4294917892 creator A5015676138 @default.
- W4294917892 creator A5018197116 @default.
- W4294917892 creator A5026576841 @default.
- W4294917892 creator A5035184056 @default.
- W4294917892 creator A5044792601 @default.
- W4294917892 creator A5044989363 @default.
- W4294917892 creator A5056718218 @default.
- W4294917892 creator A5068611347 @default.
- W4294917892 creator A5083809782 @default.
- W4294917892 creator A5091051373 @default.
- W4294917892 date "2022-09-07" @default.
- W4294917892 modified "2023-10-05" @default.
- W4294917892 title "Incidentally Detected Malignancies in Lung Explants" @default.
- W4294917892 cites W1492774104 @default.
- W4294917892 cites W2062889582 @default.
- W4294917892 cites W2069308070 @default.
- W4294917892 cites W2109871283 @default.
- W4294917892 cites W2153169173 @default.
- W4294917892 cites W2158319238 @default.
- W4294917892 cites W2163492388 @default.
- W4294917892 cites W2549748726 @default.
- W4294917892 cites W3129652669 @default.
- W4294917892 cites W4250934836 @default.
- W4294917892 doi "https://doi.org/10.1177/15269248221122876" @default.
- W4294917892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36069063" @default.
- W4294917892 hasPublicationYear "2022" @default.
- W4294917892 type Work @default.
- W4294917892 citedByCount "1" @default.
- W4294917892 countsByYear W42949178922023 @default.
- W4294917892 crossrefType "journal-article" @default.
- W4294917892 hasAuthorship W4294917892A5002289410 @default.
- W4294917892 hasAuthorship W4294917892A5002309691 @default.
- W4294917892 hasAuthorship W4294917892A5015676138 @default.
- W4294917892 hasAuthorship W4294917892A5018197116 @default.
- W4294917892 hasAuthorship W4294917892A5026576841 @default.
- W4294917892 hasAuthorship W4294917892A5035184056 @default.
- W4294917892 hasAuthorship W4294917892A5044792601 @default.
- W4294917892 hasAuthorship W4294917892A5044989363 @default.
- W4294917892 hasAuthorship W4294917892A5056718218 @default.
- W4294917892 hasAuthorship W4294917892A5068611347 @default.
- W4294917892 hasAuthorship W4294917892A5083809782 @default.
- W4294917892 hasAuthorship W4294917892A5091051373 @default.
- W4294917892 hasConcept C121608353 @default.
- W4294917892 hasConcept C126322002 @default.
- W4294917892 hasConcept C141071460 @default.
- W4294917892 hasConcept C143998085 @default.
- W4294917892 hasConcept C2776256026 @default.
- W4294917892 hasConcept C2777714996 @default.
- W4294917892 hasConcept C2779399171 @default.
- W4294917892 hasConcept C2780252810 @default.
- W4294917892 hasConcept C2781182431 @default.
- W4294917892 hasConcept C2911091166 @default.
- W4294917892 hasConcept C71924100 @default.
- W4294917892 hasConcept C90924648 @default.
- W4294917892 hasConceptScore W4294917892C121608353 @default.
- W4294917892 hasConceptScore W4294917892C126322002 @default.
- W4294917892 hasConceptScore W4294917892C141071460 @default.
- W4294917892 hasConceptScore W4294917892C143998085 @default.
- W4294917892 hasConceptScore W4294917892C2776256026 @default.
- W4294917892 hasConceptScore W4294917892C2777714996 @default.
- W4294917892 hasConceptScore W4294917892C2779399171 @default.
- W4294917892 hasConceptScore W4294917892C2780252810 @default.
- W4294917892 hasConceptScore W4294917892C2781182431 @default.
- W4294917892 hasConceptScore W4294917892C2911091166 @default.
- W4294917892 hasConceptScore W4294917892C71924100 @default.
- W4294917892 hasConceptScore W4294917892C90924648 @default.
- W4294917892 hasIssue "4" @default.
- W4294917892 hasLocation W42949178921 @default.
- W4294917892 hasLocation W42949178922 @default.
- W4294917892 hasOpenAccess W4294917892 @default.
- W4294917892 hasPrimaryLocation W42949178921 @default.
- W4294917892 hasRelatedWork W2018191311 @default.
- W4294917892 hasRelatedWork W2091635041 @default.
- W4294917892 hasRelatedWork W2155005451 @default.
- W4294917892 hasRelatedWork W2364779800 @default.
- W4294917892 hasRelatedWork W2377056512 @default.
- W4294917892 hasRelatedWork W2515088231 @default.
- W4294917892 hasRelatedWork W2562771216 @default.
- W4294917892 hasRelatedWork W2912715060 @default.
- W4294917892 hasRelatedWork W2921767730 @default.
- W4294917892 hasRelatedWork W1776799141 @default.
- W4294917892 hasVolume "32" @default.
- W4294917892 isParatext "false" @default.
- W4294917892 isRetracted "false" @default.
- W4294917892 workType "article" @default.