Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294920259> ?p ?o ?g. }
- W4294920259 abstract "Abstract Neurovascular coupling is a precise mechanism that induces increased blood flow to activated brain regions, thereby providing oxygen and glucose. In this study, we hypothesized that N-methyl-D-aspartate (NMDA) receptor signaling, the most well characterized neurotransmitter signaling system which regulates delivery of essential molecules through the blood–brain barrier (BBB). Upon application of NMDA in both in vitro and in vivo models, increased delivery of bioactive molecules that was mediated through modulation of molecules involved in molecular delivery, including clathrin and caveolin were observed. Also, NMDA activation induced structural changes in the BBB and increased transcellular permeability that showed regional heterogeneity in its responses. Moreover, NMDA receptor activation increased endosomal trafficking and facilitated inactivation of lysosomal pathways and consequently increased molecular delivery mediated by activation of calmodulin-dependent protein kinase II (CaMKII) and RhoA/protein kinase C (PKC). Subsequent in vivo experiments using mice specifically lacking NMDA receptor subunit 1 in endothelial cells showed decreased neuronal density in the brain cortex, suggesting that a deficiency in NMDA receptor signaling in brain endothelial cells induces neuronal losses. Together, these results highlight the importance of NMDA-receptor-mediated signaling in the regulation of BBB permeability that surprisingly also affected CD31 staining." @default.
- W4294920259 created "2022-09-08" @default.
- W4294920259 creator A5005001225 @default.
- W4294920259 creator A5014749404 @default.
- W4294920259 creator A5046733038 @default.
- W4294920259 creator A5072037537 @default.
- W4294920259 creator A5087620444 @default.
- W4294920259 date "2022-09-06" @default.
- W4294920259 modified "2023-10-14" @default.
- W4294920259 title "Activation of NMDA receptors in brain endothelial cells increases transcellular permeability" @default.
- W4294920259 cites W1911836937 @default.
- W4294920259 cites W1973747802 @default.
- W4294920259 cites W1975351203 @default.
- W4294920259 cites W1982483841 @default.
- W4294920259 cites W1984209530 @default.
- W4294920259 cites W1986238646 @default.
- W4294920259 cites W1989679396 @default.
- W4294920259 cites W2001729546 @default.
- W4294920259 cites W2002594335 @default.
- W4294920259 cites W2005454916 @default.
- W4294920259 cites W2007756386 @default.
- W4294920259 cites W2015541518 @default.
- W4294920259 cites W2019731805 @default.
- W4294920259 cites W2024380057 @default.
- W4294920259 cites W2025061302 @default.
- W4294920259 cites W2028267884 @default.
- W4294920259 cites W2029364696 @default.
- W4294920259 cites W2031679684 @default.
- W4294920259 cites W2035750459 @default.
- W4294920259 cites W2037852973 @default.
- W4294920259 cites W2049511526 @default.
- W4294920259 cites W2052889056 @default.
- W4294920259 cites W2053980736 @default.
- W4294920259 cites W2059334396 @default.
- W4294920259 cites W2066034304 @default.
- W4294920259 cites W2068230961 @default.
- W4294920259 cites W2073700467 @default.
- W4294920259 cites W2105157304 @default.
- W4294920259 cites W2110795253 @default.
- W4294920259 cites W2114091391 @default.
- W4294920259 cites W2117260074 @default.
- W4294920259 cites W2124365503 @default.
- W4294920259 cites W2125411036 @default.
- W4294920259 cites W2132533498 @default.
- W4294920259 cites W2133659563 @default.
- W4294920259 cites W2137841176 @default.
- W4294920259 cites W2145667182 @default.
- W4294920259 cites W2155217757 @default.
- W4294920259 cites W2160141785 @default.
- W4294920259 cites W2162968817 @default.
- W4294920259 cites W2164322384 @default.
- W4294920259 cites W2203484964 @default.
- W4294920259 cites W2329076961 @default.
- W4294920259 cites W2331341341 @default.
- W4294920259 cites W2346742153 @default.
- W4294920259 cites W2419165202 @default.
- W4294920259 cites W2464492710 @default.
- W4294920259 cites W2483981362 @default.
- W4294920259 cites W2518276547 @default.
- W4294920259 cites W2564695830 @default.
- W4294920259 cites W2611631440 @default.
- W4294920259 cites W2765083364 @default.
- W4294920259 cites W2804368056 @default.
- W4294920259 cites W2807705809 @default.
- W4294920259 cites W2889722211 @default.
- W4294920259 cites W2894305086 @default.
- W4294920259 cites W2900697639 @default.
- W4294920259 cites W2903475294 @default.
- W4294920259 cites W2944768198 @default.
- W4294920259 cites W2947173839 @default.
- W4294920259 cites W2979435077 @default.
- W4294920259 cites W2994635858 @default.
- W4294920259 cites W2999469970 @default.
- W4294920259 cites W2999651813 @default.
- W4294920259 cites W4231182105 @default.
- W4294920259 cites W67874367 @default.
- W4294920259 doi "https://doi.org/10.1186/s12987-022-00364-6" @default.
- W4294920259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36068542" @default.
- W4294920259 hasPublicationYear "2022" @default.
- W4294920259 type Work @default.
- W4294920259 citedByCount "3" @default.
- W4294920259 countsByYear W42949202592023 @default.
- W4294920259 crossrefType "journal-article" @default.
- W4294920259 hasAuthorship W4294920259A5005001225 @default.
- W4294920259 hasAuthorship W4294920259A5014749404 @default.
- W4294920259 hasAuthorship W4294920259A5046733038 @default.
- W4294920259 hasAuthorship W4294920259A5072037537 @default.
- W4294920259 hasAuthorship W4294920259A5087620444 @default.
- W4294920259 hasBestOaLocation W42949202591 @default.
- W4294920259 hasConcept C169760540 @default.
- W4294920259 hasConcept C170493617 @default.
- W4294920259 hasConcept C176285220 @default.
- W4294920259 hasConcept C185592680 @default.
- W4294920259 hasConcept C2778402981 @default.
- W4294920259 hasConcept C529278444 @default.
- W4294920259 hasConcept C55493867 @default.
- W4294920259 hasConcept C62478195 @default.
- W4294920259 hasConcept C67018056 @default.
- W4294920259 hasConcept C86803240 @default.
- W4294920259 hasConcept C95444343 @default.