Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294920956> ?p ?o ?g. }
- W4294920956 endingPage "L592" @default.
- W4294920956 startingPage "L578" @default.
- W4294920956 abstract "Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop following exposure to toxic chemicals as well as respiratory tract infections. BO development is strongly associated with diacetyl (DA) inhalation exposures at occupationally relevant concentrations or severe influenza A viral (IAV) infections. However, it remains unclear whether lower dose exposures or more mild IAV infections can result in similar pathology. In the current work, we combined these two common environmental exposures, DA and IAV, to test whether shorter DA exposures followed by sublethal IAV infection would result in similar airways disease. Adult mice exposed to DA vapors 1 h/day for 5 consecutive days followed by infection with the airway-tropic IAV H3N2 (HKx31) resulted in increased mortality, increased bronchoalveolar lavage (BAL) neutrophil percentage, mixed obstruction and restriction by lung function, and subsequent airway remodeling. Exposure to DA or IAV alone failed to result in significant pathology, whereas mice exposed to DA + IAV showed increased α-smooth muscle actin (αSMA) and epithelial cells coexpressing the basal cell marker keratin 5 (KRT5) with the club cell marker SCGB1A1. To test whether DA exposure impairs epithelial repair after IAV infection, mice were infected first with IAV and then exposed to DA during airway epithelial repair. Mice exposed to IAV + DA developed similar airway remodeling with increased subepithelial αSMA and epithelial cells coexpressing KRT5 and SCGB1A1. Our findings reveal an underappreciated concept that common environmental insults while seemingly harmless by themselves can have catastrophic implications on lung function and long-term respiratory health when combined." @default.
- W4294920956 created "2022-09-08" @default.
- W4294920956 creator A5026859426 @default.
- W4294920956 creator A5029341031 @default.
- W4294920956 creator A5034219527 @default.
- W4294920956 creator A5055508411 @default.
- W4294920956 creator A5056865783 @default.
- W4294920956 creator A5079776530 @default.
- W4294920956 date "2022-11-01" @default.
- W4294920956 modified "2023-09-25" @default.
- W4294920956 title "Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus" @default.
- W4294920956 cites W1480897266 @default.
- W4294920956 cites W1489211598 @default.
- W4294920956 cites W1966765317 @default.
- W4294920956 cites W1980544777 @default.
- W4294920956 cites W1983629624 @default.
- W4294920956 cites W1990573387 @default.
- W4294920956 cites W2004198168 @default.
- W4294920956 cites W2007921576 @default.
- W4294920956 cites W2009130780 @default.
- W4294920956 cites W2014880437 @default.
- W4294920956 cites W2016303246 @default.
- W4294920956 cites W2028871210 @default.
- W4294920956 cites W2043161346 @default.
- W4294920956 cites W2045019335 @default.
- W4294920956 cites W2047256147 @default.
- W4294920956 cites W2050776663 @default.
- W4294920956 cites W2057784225 @default.
- W4294920956 cites W2069184468 @default.
- W4294920956 cites W2090978493 @default.
- W4294920956 cites W2092080772 @default.
- W4294920956 cites W2094969755 @default.
- W4294920956 cites W2097103956 @default.
- W4294920956 cites W2103305394 @default.
- W4294920956 cites W2106772621 @default.
- W4294920956 cites W2107137823 @default.
- W4294920956 cites W2108720463 @default.
- W4294920956 cites W2109251917 @default.
- W4294920956 cites W2112879706 @default.
- W4294920956 cites W2114738541 @default.
- W4294920956 cites W2130385399 @default.
- W4294920956 cites W2130752844 @default.
- W4294920956 cites W2132872843 @default.
- W4294920956 cites W2135951248 @default.
- W4294920956 cites W2139522939 @default.
- W4294920956 cites W2143645698 @default.
- W4294920956 cites W2156013329 @default.
- W4294920956 cites W2156561769 @default.
- W4294920956 cites W2159042249 @default.
- W4294920956 cites W2165275453 @default.
- W4294920956 cites W2171135911 @default.
- W4294920956 cites W2171927851 @default.
- W4294920956 cites W2258849554 @default.
- W4294920956 cites W2280895822 @default.
- W4294920956 cites W2334225757 @default.
- W4294920956 cites W2338696276 @default.
- W4294920956 cites W2391187937 @default.
- W4294920956 cites W2498675133 @default.
- W4294920956 cites W2518536270 @default.
- W4294920956 cites W2525110976 @default.
- W4294920956 cites W2529961986 @default.
- W4294920956 cites W2556107206 @default.
- W4294920956 cites W2563380014 @default.
- W4294920956 cites W2572020026 @default.
- W4294920956 cites W2585928706 @default.
- W4294920956 cites W2594783826 @default.
- W4294920956 cites W2607489431 @default.
- W4294920956 cites W2610194775 @default.
- W4294920956 cites W2735776329 @default.
- W4294920956 cites W2745776364 @default.
- W4294920956 cites W2805040151 @default.
- W4294920956 cites W2904286153 @default.
- W4294920956 cites W2922510100 @default.
- W4294920956 cites W2925162315 @default.
- W4294920956 cites W2969681105 @default.
- W4294920956 cites W2994965141 @default.
- W4294920956 cites W3008377159 @default.
- W4294920956 cites W3025586365 @default.
- W4294920956 cites W3088076726 @default.
- W4294920956 cites W3164367497 @default.
- W4294920956 cites W4200082237 @default.
- W4294920956 cites W4211058537 @default.
- W4294920956 cites W4211071051 @default.
- W4294920956 cites W4212806178 @default.
- W4294920956 cites W4238650021 @default.
- W4294920956 cites W4285194967 @default.
- W4294920956 doi "https://doi.org/10.1152/ajplung.00124.2022" @default.
- W4294920956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36068185" @default.
- W4294920956 hasPublicationYear "2022" @default.
- W4294920956 type Work @default.
- W4294920956 citedByCount "0" @default.
- W4294920956 crossrefType "journal-article" @default.
- W4294920956 hasAuthorship W4294920956A5026859426 @default.
- W4294920956 hasAuthorship W4294920956A5029341031 @default.
- W4294920956 hasAuthorship W4294920956A5034219527 @default.
- W4294920956 hasAuthorship W4294920956A5055508411 @default.
- W4294920956 hasAuthorship W4294920956A5056865783 @default.
- W4294920956 hasAuthorship W4294920956A5079776530 @default.