Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294927209> ?p ?o ?g. }
- W4294927209 abstract "Abstract Purpose Immune checkpoint inhibitor (ICI) therapy has revolutionized cancer care but is associated with immune-related adverse events (irAEs). Recent case reports raised the concern that acute appendicitis may be an irAE. In this study, we sought to describe the disease course of post-ICI therapy appendicitis and its associated complications. Methods Adult patients who had an International Classification of Diseases code for appendicitis within the first 2 years after initiating ICI therapy from January 2010 to April 2021 and who had imaging evidence of appendicitis were studied retrospectively. Results 13,991 patients were identified who had ICI exposure during the study period, 44 had codes for appendicitis, 10 of whom met the inclusion criteria. Their median age at the time of diagnosis was 59 years. The median time from ICI therapy initiation to appendicitis onset was 188 days. The most common presenting symptoms were abdominal pain (70%) and fever (40%). Abscesses were present in two patients, and a perforation was present in one. All 10 patients received broad-spectrum antibiotics. Five patients needed surgery or interventional radiology drainage. Nine patients had resolution of appendicitis symptoms after treatment. Conclusion Post-ICI therapy appendicitis is rare but presents similarly to and has similar complications rates as conventional appendicitis. Appendectomy remains the mainstay of treatment, but its use can be limited in cancer patients. The decision to continue ICI therapy remains at the discretion of the clinician. Further studies are needed to bring awareness to and advance the understanding of this clinical entity." @default.
- W4294927209 created "2022-09-08" @default.
- W4294927209 creator A5003027125 @default.
- W4294927209 creator A5003873827 @default.
- W4294927209 creator A5013244136 @default.
- W4294927209 creator A5021941792 @default.
- W4294927209 creator A5039869596 @default.
- W4294927209 creator A5042917768 @default.
- W4294927209 creator A5052738174 @default.
- W4294927209 creator A5071593155 @default.
- W4294927209 creator A5073007668 @default.
- W4294927209 creator A5078319904 @default.
- W4294927209 date "2022-09-07" @default.
- W4294927209 modified "2023-09-27" @default.
- W4294927209 title "Characteristics of Appendicitis after Immune Checkpoint Inhibitor Therapy among Cancer Patients" @default.
- W4294927209 cites W1552557715 @default.
- W4294927209 cites W1972941788 @default.
- W4294927209 cites W1977659641 @default.
- W4294927209 cites W2013916008 @default.
- W4294927209 cites W2018040008 @default.
- W4294927209 cites W2051786922 @default.
- W4294927209 cites W2116593658 @default.
- W4294927209 cites W2120091928 @default.
- W4294927209 cites W2138963221 @default.
- W4294927209 cites W2140780207 @default.
- W4294927209 cites W2163906584 @default.
- W4294927209 cites W2164268581 @default.
- W4294927209 cites W2275606382 @default.
- W4294927209 cites W2544715348 @default.
- W4294927209 cites W2583549666 @default.
- W4294927209 cites W2618060945 @default.
- W4294927209 cites W2775870938 @default.
- W4294927209 cites W2783137027 @default.
- W4294927209 cites W2791199806 @default.
- W4294927209 cites W2800213865 @default.
- W4294927209 cites W2805482047 @default.
- W4294927209 cites W2892885739 @default.
- W4294927209 cites W2898631010 @default.
- W4294927209 cites W2901658897 @default.
- W4294927209 cites W2904212099 @default.
- W4294927209 cites W2912554016 @default.
- W4294927209 cites W2915818060 @default.
- W4294927209 cites W2945821127 @default.
- W4294927209 cites W2948533059 @default.
- W4294927209 cites W2971491136 @default.
- W4294927209 cites W2993164107 @default.
- W4294927209 cites W3010839046 @default.
- W4294927209 cites W3017264036 @default.
- W4294927209 cites W3087778190 @default.
- W4294927209 cites W3196466393 @default.
- W4294927209 cites W3199126672 @default.
- W4294927209 cites W3208126097 @default.
- W4294927209 cites W3217172351 @default.
- W4294927209 doi "https://doi.org/10.21203/rs.3.rs-2027490/v1" @default.
- W4294927209 hasPublicationYear "2022" @default.
- W4294927209 type Work @default.
- W4294927209 citedByCount "0" @default.
- W4294927209 crossrefType "posted-content" @default.
- W4294927209 hasAuthorship W4294927209A5003027125 @default.
- W4294927209 hasAuthorship W4294927209A5003873827 @default.
- W4294927209 hasAuthorship W4294927209A5013244136 @default.
- W4294927209 hasAuthorship W4294927209A5021941792 @default.
- W4294927209 hasAuthorship W4294927209A5039869596 @default.
- W4294927209 hasAuthorship W4294927209A5042917768 @default.
- W4294927209 hasAuthorship W4294927209A5052738174 @default.
- W4294927209 hasAuthorship W4294927209A5071593155 @default.
- W4294927209 hasAuthorship W4294927209A5073007668 @default.
- W4294927209 hasAuthorship W4294927209A5078319904 @default.
- W4294927209 hasBestOaLocation W42949272091 @default.
- W4294927209 hasConcept C121608353 @default.
- W4294927209 hasConcept C126322002 @default.
- W4294927209 hasConcept C141071460 @default.
- W4294927209 hasConcept C191897082 @default.
- W4294927209 hasConcept C192562407 @default.
- W4294927209 hasConcept C197934379 @default.
- W4294927209 hasConcept C2778456384 @default.
- W4294927209 hasConcept C2778527123 @default.
- W4294927209 hasConcept C2780016130 @default.
- W4294927209 hasConcept C2780955771 @default.
- W4294927209 hasConcept C526805850 @default.
- W4294927209 hasConcept C61434518 @default.
- W4294927209 hasConcept C71924100 @default.
- W4294927209 hasConceptScore W4294927209C121608353 @default.
- W4294927209 hasConceptScore W4294927209C126322002 @default.
- W4294927209 hasConceptScore W4294927209C141071460 @default.
- W4294927209 hasConceptScore W4294927209C191897082 @default.
- W4294927209 hasConceptScore W4294927209C192562407 @default.
- W4294927209 hasConceptScore W4294927209C197934379 @default.
- W4294927209 hasConceptScore W4294927209C2778456384 @default.
- W4294927209 hasConceptScore W4294927209C2778527123 @default.
- W4294927209 hasConceptScore W4294927209C2780016130 @default.
- W4294927209 hasConceptScore W4294927209C2780955771 @default.
- W4294927209 hasConceptScore W4294927209C526805850 @default.
- W4294927209 hasConceptScore W4294927209C61434518 @default.
- W4294927209 hasConceptScore W4294927209C71924100 @default.
- W4294927209 hasLocation W42949272091 @default.
- W4294927209 hasOpenAccess W4294927209 @default.
- W4294927209 hasPrimaryLocation W42949272091 @default.
- W4294927209 hasRelatedWork W1557895063 @default.
- W4294927209 hasRelatedWork W2056667216 @default.