Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294938892> ?p ?o ?g. }
- W4294938892 endingPage "115" @default.
- W4294938892 startingPage "106" @default.
- W4294938892 abstract "Overexposure of the developing fetus to glucocorticoids is hypothesised to be one of the key mechanisms linking early life development with later life disease. The maternal hypothalamic-pituitary-adrenal (HPA) axis undergoes dramatic changes during pregnancy and postpartum. Although cortisol levels rise threefold by the third trimester, the fetus is partially protected from high cortisol by activity of the enzyme 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2). Maternal HPA axis activity and activity of HSD11B2 may be modified by maternal stress and disease allowing greater transfer of glucocorticoids from mother to fetus. Here we review emerging data from human studies linking dysregulation of the maternal HPA axis to outcomes in both the mother and her offspring. For the offspring, greater glucocorticoid exposure is associated with lower birth weight and shorter gestation at delivery. In addition, evidence supports longer term consequences for the offspring including re-setting of the HPA axis and susceptibility to neurodevelopmental problems and cardiometabolic disease. For the mother, the changes in the HPA axis, particularly in the postpartum period, may increase vulnerability to mood disturbances. Further understanding of the changes in the HPA axis during pregnancy and the impact of these changes may ultimately allow early identification of those most at risk of future disease." @default.
- W4294938892 created "2022-09-08" @default.
- W4294938892 creator A5007029978 @default.
- W4294938892 creator A5087928736 @default.
- W4294938892 date "2013-01-01" @default.
- W4294938892 modified "2023-10-14" @default.
- W4294938892 title "Changes in the Maternal Hypothalamic-Pituitary-Adrenal Axis in Pregnancy and Postpartum: Influences on Maternal and Fetal Outcomes" @default.
- W4294938892 cites W1506653333 @default.
- W4294938892 cites W1629160377 @default.
- W4294938892 cites W1929172805 @default.
- W4294938892 cites W1964057651 @default.
- W4294938892 cites W1965153087 @default.
- W4294938892 cites W1965189371 @default.
- W4294938892 cites W1970717430 @default.
- W4294938892 cites W1974636892 @default.
- W4294938892 cites W1975577062 @default.
- W4294938892 cites W1976186999 @default.
- W4294938892 cites W1979522937 @default.
- W4294938892 cites W1980122541 @default.
- W4294938892 cites W1980400924 @default.
- W4294938892 cites W1981803152 @default.
- W4294938892 cites W1986005240 @default.
- W4294938892 cites W1990496792 @default.
- W4294938892 cites W1990652217 @default.
- W4294938892 cites W1995623240 @default.
- W4294938892 cites W1997530953 @default.
- W4294938892 cites W1998136841 @default.
- W4294938892 cites W2002193475 @default.
- W4294938892 cites W2005782560 @default.
- W4294938892 cites W2007914177 @default.
- W4294938892 cites W2008865536 @default.
- W4294938892 cites W2011422515 @default.
- W4294938892 cites W2016428032 @default.
- W4294938892 cites W2020095098 @default.
- W4294938892 cites W2020469940 @default.
- W4294938892 cites W2020747926 @default.
- W4294938892 cites W2024208207 @default.
- W4294938892 cites W2025321978 @default.
- W4294938892 cites W2025531083 @default.
- W4294938892 cites W2028139121 @default.
- W4294938892 cites W2040626130 @default.
- W4294938892 cites W2041013321 @default.
- W4294938892 cites W2041661028 @default.
- W4294938892 cites W2041726007 @default.
- W4294938892 cites W2044872939 @default.
- W4294938892 cites W2046678424 @default.
- W4294938892 cites W2047372093 @default.
- W4294938892 cites W2047907599 @default.
- W4294938892 cites W2050781791 @default.
- W4294938892 cites W2053197646 @default.
- W4294938892 cites W2054553790 @default.
- W4294938892 cites W2054692302 @default.
- W4294938892 cites W2054843309 @default.
- W4294938892 cites W2055001133 @default.
- W4294938892 cites W2057461494 @default.
- W4294938892 cites W2058741090 @default.
- W4294938892 cites W2064210729 @default.
- W4294938892 cites W2065109634 @default.
- W4294938892 cites W2066276157 @default.
- W4294938892 cites W2066279187 @default.
- W4294938892 cites W2069266080 @default.
- W4294938892 cites W2070602780 @default.
- W4294938892 cites W2071878822 @default.
- W4294938892 cites W2074593405 @default.
- W4294938892 cites W2082866706 @default.
- W4294938892 cites W2085777181 @default.
- W4294938892 cites W2086526747 @default.
- W4294938892 cites W2087391234 @default.
- W4294938892 cites W2088414941 @default.
- W4294938892 cites W2090053767 @default.
- W4294938892 cites W2090986608 @default.
- W4294938892 cites W2091080087 @default.
- W4294938892 cites W2095082202 @default.
- W4294938892 cites W2096299057 @default.
- W4294938892 cites W2098257056 @default.
- W4294938892 cites W2099228366 @default.
- W4294938892 cites W2101189704 @default.
- W4294938892 cites W2102418649 @default.
- W4294938892 cites W2102536599 @default.
- W4294938892 cites W2104596768 @default.
- W4294938892 cites W2105598674 @default.
- W4294938892 cites W2107795985 @default.
- W4294938892 cites W2114835551 @default.
- W4294938892 cites W2120743339 @default.
- W4294938892 cites W2121401314 @default.
- W4294938892 cites W2122548940 @default.
- W4294938892 cites W2124209493 @default.
- W4294938892 cites W2127494620 @default.
- W4294938892 cites W2127506347 @default.
- W4294938892 cites W2128256893 @default.
- W4294938892 cites W2128337375 @default.
- W4294938892 cites W2130839930 @default.
- W4294938892 cites W2131079686 @default.
- W4294938892 cites W2131140619 @default.
- W4294938892 cites W2131165622 @default.
- W4294938892 cites W2132197400 @default.
- W4294938892 cites W2137686588 @default.
- W4294938892 cites W2139305535 @default.