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• W4294955963 abstract "Long noncoding RNAs (lncRNAs) have increasingly been recognized as being integral to cellular processes, including the antiviral immune response. Porcine reproductive and respiratory syndrome virus (PRRSV) is costly to the global swine industry. To identify PRRSV-related lncRNAs, we performed RNA deep sequencing and compared the profiles of lncRNAs in PRRSV-infected and uninfected Marc-145 cells. We identified a novel lncRNA called MAHAT (maintaining cell morphology-associated and highly conserved antiviral transcript; LTCON_00080558) that inhibits PRRSV replication. MAHAT binds and negatively regulates ZNF34 expression by recruiting and binding DDX6, an RNA helicase forming a complex with ZNF34. Inhibition of ZNF34 expression results in increased type I interferon expression and decreased PRRSV replication. This finding reveals a novel mechanism by which PRRSV evades the host antiviral innate immune response by downregulating the MAHAT-DDX6-ZNF34 pathway. MAHAT could be a host factor target for antiviral therapies against PRRSV infection. IMPORTANCE Long noncoding RNAs (lncRNAs) play important roles in viral infection by regulating the transcription and expression of host genes, and interferon signaling pathways. Porcine reproductive and respiratory syndrome virus (PRRSV) causes huge economic losses in the swine industry worldwide, but the mechanisms of its pathogenesis and immunology are not fully understood. Here, a new lncRNA, designated MAHAT, was identified as a regulator of host innate immune responses. MAHAT negatively regulates the expression of its target gene, ZNF34, by recruiting and binding DDX6, an RNA helicase, forming a complex with ZNF34. Inhibition of ZNF34 expression increases type I interferon expression and decreases PRRSV replication. This finding suggests that MAHAT has potential as a new target for developing antiviral drugs against PRRSV infection." @default.
• W4294955963 created "2022-09-08" @default.
• W4294955963 creator A5005602487 @default.
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• W4294955963 date "2022-09-28" @default.
• W4294955963 modified "2023-10-14" @default.
• W4294955963 title "A New Long Noncoding RNA, MAHAT, Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Recruiting DDX6 To Bind to <i>ZNF34</i> and Promote an Innate Immune Response" @default.
• W4294955963 cites W1823284737 @default.
• W4294955963 cites W1894294129 @default.
• W4294955963 cites W1994983007 @default.
• W4294955963 cites W2006936482 @default.
• W4294955963 cites W2015721404 @default.
• W4294955963 cites W2025031008 @default.
• W4294955963 cites W2040654802 @default.
• W4294955963 cites W2048194168 @default.
• W4294955963 cites W2050509264 @default.
• W4294955963 cites W2071700214 @default.
• W4294955963 cites W2080514465 @default.
• W4294955963 cites W2091934163 @default.
• W4294955963 cites W2093606554 @default.
• W4294955963 cites W2100867908 @default.
• W4294955963 cites W2103692755 @default.
• W4294955963 cites W2105349784 @default.
• W4294955963 cites W2116739202 @default.
• W4294955963 cites W2125569948 @default.
• W4294955963 cites W2130014003 @default.
• W4294955963 cites W2133109371 @default.
• W4294955963 cites W2138124339 @default.
• W4294955963 cites W2142581353 @default.
• W4294955963 cites W2161159766 @default.
• W4294955963 cites W2163303092 @default.
• W4294955963 cites W2166574880 @default.
• W4294955963 cites W2169602184 @default.
• W4294955963 cites W2173730847 @default.
• W4294955963 cites W2174186223 @default.
• W4294955963 cites W2276978390 @default.
• W4294955963 cites W2282529067 @default.
• W4294955963 cites W2335029242 @default.
• W4294955963 cites W2403143312 @default.
• W4294955963 cites W2423205648 @default.
• W4294955963 cites W2466679137 @default.
• W4294955963 cites W2528828967 @default.
• W4294955963 cites W2571060577 @default.
• W4294955963 cites W2730491138 @default.
• W4294955963 cites W2736391469 @default.
• W4294955963 cites W2738983891 @default.
• W4294955963 cites W2742305663 @default.
• W4294955963 cites W2748551035 @default.
• W4294955963 cites W2757270021 @default.
• W4294955963 cites W2765664383 @default.
• W4294955963 cites W2771184879 @default.
• W4294955963 cites W2803811287 @default.
• W4294955963 cites W2807104827 @default.
• W4294955963 cites W2899013095 @default.
• W4294955963 cites W2915534090 @default.
• W4294955963 cites W2917971614 @default.
• W4294955963 cites W2921585875 @default.
• W4294955963 cites W2926902798 @default.
• W4294955963 cites W2942809049 @default.
• W4294955963 cites W2947296232 @default.
• W4294955963 cites W2948403305 @default.
• W4294955963 cites W2952810289 @default.
• W4294955963 cites W2972890624 @default.
• W4294955963 cites W2974905927 @default.
• W4294955963 cites W2976172507 @default.
• W4294955963 cites W2977721529 @default.
• W4294955963 cites W3005201319 @default.
• W4294955963 cites W3016530658 @default.
• W4294955963 cites W3024915888 @default.
• W4294955963 cites W3029953567 @default.
• W4294955963 cites W3036017089 @default.
• W4294955963 cites W3049675043 @default.
• W4294955963 cites W3082882712 @default.
• W4294955963 cites W3083694860 @default.
• W4294955963 cites W3099284546 @default.
• W4294955963 cites W3104955345 @default.
• W4294955963 cites W3112207312 @default.
• W4294955963 cites W3136303338 @default.
• W4294955963 cites W3137944120 @default.
• W4294955963 cites W3139402920 @default.
• W4294955963 cites W3158699050 @default.
• W4294955963 cites W3164820215 @default.
• W4294955963 cites W3164972601 @default.
• W4294955963 cites W3167713016 @default.
• W4294955963 cites W3176943685 @default.
• W4294955963 cites W3185232789 @default.
• W4294955963 cites W3191225437 @default.
• W4294955963 cites W3197787764 @default.
• W4294955963 cites W4211009269 @default.
• W4294955963 cites W4221037124 @default.
• W4294955963 cites W4285203861 @default.
• W4294955963 doi "https://doi.org/10.1128/jvi.01154-22" @default.
• W4294955963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36073922" @default.
• W4294955963 hasPublicationYear "2022" @default.

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