FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294958435> ?p ?o ?g. }

• W4294958435 endingPage "102472" @default.
• W4294958435 startingPage "102472" @default.
• W4294958435 abstract "The membrane-bound complex II family of proteins is composed of enzymes that catalyze succinate and fumarate interconversion coupled with reduction or oxidation of quinones within the membrane domain. The majority of complex II enzymes are protein heterotetramers with the different subunits harboring a variety of redox centers. These redox centers are used to transfer electrons between the site of succinate-fumarate oxidation/reduction and the membrane domain harboring the quinone. A covalently bound FAD cofactor is present in the flavoprotein subunit, and the covalent flavin linkage is absolutely required to enable the enzyme to oxidize succinate. Assembly of the covalent flavin linkage in eukaryotic cells and many bacteria requires additional protein assembly factors. Here, we provide mechanistic details for how the assembly factors work to enhance covalent flavinylation. Both prokaryotic SdhE and mammalian SDHAF2 enhance FAD binding to their respective apoprotein of complex II. These assembly factors also increase the affinity for dicarboxylates to the apoprotein-noncovalent FAD complex and stabilize the preassembly complex. These findings are corroborated by previous investigations of the roles of SdhE in enhancing covalent flavinylation in both bacterial succinate dehydrogenase and fumarate reductase flavoprotein subunits and of SDHAF2 in performing the same function for the human mitochondrial succinate dehydrogenase flavoprotein. In conclusion, we provide further insight into assembly factor involvement in building complex II flavoprotein subunit active site required for succinate oxidation." @default.
• W4294958435 created "2022-09-08" @default.
• W4294958435 creator A5013786719 @default.
• W4294958435 creator A5016926827 @default.
• W4294958435 creator A5060957747 @default.
• W4294958435 date "2022-10-01" @default.
• W4294958435 modified "2023-10-17" @default.
• W4294958435 title "How an assembly factor enhances covalent FAD attachment to the flavoprotein subunit of complex II" @default.
• W4294958435 cites W1516181260 @default.
• W4294958435 cites W1564968454 @default.
• W4294958435 cites W1580235264 @default.
• W4294958435 cites W1593380345 @default.
• W4294958435 cites W1664438812 @default.
• W4294958435 cites W1870394013 @default.
• W4294958435 cites W1882140875 @default.
• W4294958435 cites W1916949121 @default.
• W4294958435 cites W1964025113 @default.
• W4294958435 cites W1976019788 @default.
• W4294958435 cites W1980270634 @default.
• W4294958435 cites W1990098147 @default.
• W4294958435 cites W2003125843 @default.
• W4294958435 cites W2007590134 @default.
• W4294958435 cites W2014522149 @default.
• W4294958435 cites W2024270423 @default.
• W4294958435 cites W2028117213 @default.
• W4294958435 cites W2029913956 @default.
• W4294958435 cites W2037164946 @default.
• W4294958435 cites W2044412059 @default.
• W4294958435 cites W2044414180 @default.
• W4294958435 cites W2051090871 @default.
• W4294958435 cites W2057000083 @default.
• W4294958435 cites W2062685621 @default.
• W4294958435 cites W2073469088 @default.
• W4294958435 cites W2075420247 @default.
• W4294958435 cites W2089779289 @default.
• W4294958435 cites W2091628243 @default.
• W4294958435 cites W2093007887 @default.
• W4294958435 cites W2098387216 @default.
• W4294958435 cites W2112438801 @default.
• W4294958435 cites W2135414906 @default.
• W4294958435 cites W2136430686 @default.
• W4294958435 cites W2140237162 @default.
• W4294958435 cites W2154665416 @default.
• W4294958435 cites W2156965186 @default.
• W4294958435 cites W2196102194 @default.
• W4294958435 cites W2516527485 @default.
• W4294958435 cites W2528211287 @default.
• W4294958435 cites W2615104605 @default.
• W4294958435 cites W2791860947 @default.
• W4294958435 cites W2796360169 @default.
• W4294958435 cites W2805738790 @default.
• W4294958435 cites W2905406395 @default.
• W4294958435 cites W2916688858 @default.
• W4294958435 cites W2947190494 @default.
• W4294958435 cites W2999631926 @default.
• W4294958435 cites W3083434651 @default.
• W4294958435 cites W3113218741 @default.
• W4294958435 cites W3203133702 @default.
• W4294958435 cites W3213781013 @default.
• W4294958435 cites W3216741310 @default.
• W4294958435 cites W3217375757 @default.
• W4294958435 cites W4210246513 @default.
• W4294958435 cites W4240660225 @default.
• W4294958435 cites W67565410 @default.
• W4294958435 cites W7827006 @default.
• W4294958435 cites W876310579 @default.
• W4294958435 doi "https://doi.org/10.1016/j.jbc.2022.102472" @default.
• W4294958435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36089066" @default.
• W4294958435 hasPublicationYear "2022" @default.
• W4294958435 type Work @default.
• W4294958435 citedByCount "2" @default.
• W4294958435 countsByYear W42949584352023 @default.
• W4294958435 crossrefType "journal-article" @default.
• W4294958435 hasAuthorship W4294958435A5013786719 @default.
• W4294958435 hasAuthorship W4294958435A5016926827 @default.
• W4294958435 hasAuthorship W4294958435A5060957747 @default.
• W4294958435 hasBestOaLocation W42949584351 @default.
• W4294958435 hasConcept C104292427 @default.
• W4294958435 hasConcept C104317684 @default.
• W4294958435 hasConcept C121612415 @default.
• W4294958435 hasConcept C178790620 @default.
• W4294958435 hasConcept C180577832 @default.
• W4294958435 hasConcept C181199279 @default.
• W4294958435 hasConcept C185592680 @default.
• W4294958435 hasConcept C197957613 @default.
• W4294958435 hasConcept C2775859393 @default.
• W4294958435 hasConcept C2776317432 @default.
• W4294958435 hasConcept C2781330172 @default.
• W4294958435 hasConcept C33093398 @default.
• W4294958435 hasConcept C55493867 @default.
• W4294958435 hasConcept C71240020 @default.
• W4294958435 hasConcept C71995715 @default.
• W4294958435 hasConceptScore W4294958435C104292427 @default.
• W4294958435 hasConceptScore W4294958435C104317684 @default.
• W4294958435 hasConceptScore W4294958435C121612415 @default.
• W4294958435 hasConceptScore W4294958435C178790620 @default.
• W4294958435 hasConceptScore W4294958435C180577832 @default.
• W4294958435 hasConceptScore W4294958435C181199279 @default.

• next