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• W4294959645 abstract "Background: Asthma is a complex disorder with variable clinical expression. Recognizable clinical and laboratory features define phenotypes, and specific biologic pathways define endotypes. Identifying the specific pathway responsible for persistent asthma would enable the clinician to select the optimal inhibitors, which currently are biologic therapies. Objective: To provide an up-to-date review of the current clinical status of endotype and phenotype characterizations of asthma and discuss these categories in relation to the available, or likely available, biologic therapies for asthma. Methods: The medical literature was reviewed based on the search terms: asthma biologics, severe asthma, uncontrolled asthma, corticosteroid-dependent asthma, phenotype, endotype, and type 2. We also used our knowledge of the literature and current research. Results: All of the current biologics, including the recently approved tezepelumab, were most effective with increased type 2 biomarkers, which identify exacerbation-prone asthma. Current biomarkers do not permit consistent identification of specific endotypes to facilitate informed selection of the optimal therapy for an individual patient. Thus, empiricism and the art of care continue to play major roles in treatment selection. Conclusion: Current biologic therapies for asthma and those likely to be U.S. Food and Drug Administration approved within the near future work best in subjects with strong type 2 signatures. Available biomarkers and observable characteristics do not enable clinicians to recognize specific endotypes, but rather subphenotypes or overlapping endotypes. The goal of identifying the optimal patient for a specific therapy remains elusive, but worthy of pursuit. In the interim, the availability of an increasing number of treatment options allows the clinician to help most of his or her patients." @default.
• W4294959645 created "2022-09-08" @default.
• W4294959645 creator A5003603772 @default.
• W4294959645 creator A5004381470 @default.
• W4294959645 creator A5032575831 @default.
• W4294959645 date "2022-09-01" @default.
• W4294959645 modified "2023-10-06" @default.
• W4294959645 title "Clinical implications of asthma endotypes and phenotypes" @default.
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• W4294959645 doi "https://doi.org/10.2500/aap.2022.43.220047" @default.
• W4294959645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36065106" @default.
• W4294959645 hasPublicationYear "2022" @default.
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