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- W4294975188 abstract "Archetypal analysis (AA) is a versatile data analysis method to cluster distinct features within a data set. Here, we demonstrate a framework showing the power of AA to spatio-temporally resolve events in calcium imaging, an imaging modality commonly used in neurobiology and neuroscience to capture neuronal communication patterns. After validation of our AA-based approach on synthetic data sets, we were able to characterize neuronal communication patterns in recorded calcium waves. Clinical relevance- Transient calcium events play an essential role in brain cell communication, growth, and network formation, as well as in neurodegeneration. To reliably interpret calcium events from personalized medicine data, where patterns may differ from patient to patient, appropriate image processing and signal analysis methods need to be developed for optimal network characterization." @default.
- W4294975188 created "2022-09-08" @default.
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- W4294975188 date "2022-07-11" @default.
- W4294975188 modified "2023-10-16" @default.
- W4294975188 title "Archetypal Analysis for neuronal clique detection in low-rate calcium fluorescence imaging" @default.
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- W4294975188 doi "https://doi.org/10.1109/embc48229.2022.9871404" @default.
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