Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294983513> ?p ?o ?g. }
- W4294983513 endingPage "2274" @default.
- W4294983513 startingPage "2274" @default.
- W4294983513 abstract "Recently, miR-22 has been suggested to be an important microRNA (miRNA) affecting meat quality. Studies have shown that muscle fatty acid composition and mitochondrial function are closely related to meat quality. The regulatory mechanism of miR-22 on skeletal muscle fatty acid composition and mitochondrial function is not well characterized. Therefore, we aimed to explore the effects of miR-22 on fatty acid composition and mitochondrial function in C2C12 cells. Here, it demonstrate that elevated expression of miR-22 significantly repressed fatty acid elongation and mitochondrial morphology in C2C12 myoblasts, while the knockdown of miR-22 showed opposite results. Furthermore, miR-22 targets the elongase of very long chain fatty acids 6 (ELOVL6) and represses its expression in muscle cells. Knockdown of ELOVL6 mimicked the effect of miR-22 on fatty acid composition and mitochondrial function, while overexpression of ELOVL6 restored the effects of miR-22. These findings indicate that miR-22 downregulates the elongation of fatty acids and mitochondrial morphology by inhibiting ELOVL6 expression in muscle cells, which may provide some useful information for controlling muscle lipid accumulation and mitochondrial function in livestock in the future." @default.
- W4294983513 created "2022-09-08" @default.
- W4294983513 creator A5004050646 @default.
- W4294983513 creator A5016772356 @default.
- W4294983513 creator A5024017574 @default.
- W4294983513 creator A5028563678 @default.
- W4294983513 creator A5058366139 @default.
- W4294983513 creator A5060464401 @default.
- W4294983513 creator A5066438431 @default.
- W4294983513 creator A5075703251 @default.
- W4294983513 creator A5088824836 @default.
- W4294983513 date "2022-09-02" @default.
- W4294983513 modified "2023-09-25" @default.
- W4294983513 title "A Specific microRNA Targets an Elongase of Very Long Chain Fatty Acids to Regulate Fatty Acid Composition and Mitochondrial Morphology of Skeletal Muscle Cells" @default.
- W4294983513 cites W1616626961 @default.
- W4294983513 cites W1752520412 @default.
- W4294983513 cites W1803838592 @default.
- W4294983513 cites W1817200006 @default.
- W4294983513 cites W1963848785 @default.
- W4294983513 cites W1968730473 @default.
- W4294983513 cites W1968798078 @default.
- W4294983513 cites W1970742125 @default.
- W4294983513 cites W1972666591 @default.
- W4294983513 cites W1983487528 @default.
- W4294983513 cites W1993206672 @default.
- W4294983513 cites W1994302475 @default.
- W4294983513 cites W1999919904 @default.
- W4294983513 cites W2004535935 @default.
- W4294983513 cites W2005895082 @default.
- W4294983513 cites W2027714505 @default.
- W4294983513 cites W2036027854 @default.
- W4294983513 cites W2047836380 @default.
- W4294983513 cites W2062136715 @default.
- W4294983513 cites W2068281966 @default.
- W4294983513 cites W2085796347 @default.
- W4294983513 cites W2090264090 @default.
- W4294983513 cites W2106127270 @default.
- W4294983513 cites W2107277218 @default.
- W4294983513 cites W2107324877 @default.
- W4294983513 cites W2110498369 @default.
- W4294983513 cites W2115936516 @default.
- W4294983513 cites W2116372788 @default.
- W4294983513 cites W2128042063 @default.
- W4294983513 cites W2136490020 @default.
- W4294983513 cites W2140751228 @default.
- W4294983513 cites W2144655785 @default.
- W4294983513 cites W2148568691 @default.
- W4294983513 cites W2192080449 @default.
- W4294983513 cites W2229506676 @default.
- W4294983513 cites W2273422532 @default.
- W4294983513 cites W2282823150 @default.
- W4294983513 cites W2312100463 @default.
- W4294983513 cites W2346277053 @default.
- W4294983513 cites W2430526660 @default.
- W4294983513 cites W2595185666 @default.
- W4294983513 cites W2595583878 @default.
- W4294983513 cites W2604621693 @default.
- W4294983513 cites W2607211950 @default.
- W4294983513 cites W2790562444 @default.
- W4294983513 cites W2885392010 @default.
- W4294983513 cites W2891811141 @default.
- W4294983513 cites W2920519307 @default.
- W4294983513 cites W3025826557 @default.
- W4294983513 cites W3088801350 @default.
- W4294983513 cites W3111895679 @default.
- W4294983513 cites W4231141707 @default.
- W4294983513 doi "https://doi.org/10.3390/ani12172274" @default.
- W4294983513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36077994" @default.
- W4294983513 hasPublicationYear "2022" @default.
- W4294983513 type Work @default.
- W4294983513 citedByCount "1" @default.
- W4294983513 countsByYear W42949835132023 @default.
- W4294983513 crossrefType "journal-article" @default.
- W4294983513 hasAuthorship W4294983513A5004050646 @default.
- W4294983513 hasAuthorship W4294983513A5016772356 @default.
- W4294983513 hasAuthorship W4294983513A5024017574 @default.
- W4294983513 hasAuthorship W4294983513A5028563678 @default.
- W4294983513 hasAuthorship W4294983513A5058366139 @default.
- W4294983513 hasAuthorship W4294983513A5060464401 @default.
- W4294983513 hasAuthorship W4294983513A5066438431 @default.
- W4294983513 hasAuthorship W4294983513A5075703251 @default.
- W4294983513 hasAuthorship W4294983513A5088824836 @default.
- W4294983513 hasBestOaLocation W42949835131 @default.
- W4294983513 hasConcept C134018914 @default.
- W4294983513 hasConcept C14036430 @default.
- W4294983513 hasConcept C173396325 @default.
- W4294983513 hasConcept C190283241 @default.
- W4294983513 hasConcept C207200792 @default.
- W4294983513 hasConcept C2779959927 @default.
- W4294983513 hasConcept C28859421 @default.
- W4294983513 hasConcept C3763915 @default.
- W4294983513 hasConcept C543025807 @default.
- W4294983513 hasConcept C55493867 @default.
- W4294983513 hasConcept C60278653 @default.
- W4294983513 hasConcept C86803240 @default.
- W4294983513 hasConcept C95444343 @default.
- W4294983513 hasConceptScore W4294983513C134018914 @default.
- W4294983513 hasConceptScore W4294983513C14036430 @default.