Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294989805> ?p ?o ?g. }
- W4294989805 endingPage "2172" @default.
- W4294989805 startingPage "2172" @default.
- W4294989805 abstract "In the absence of antiviral therapy, HIV-1 infection progresses to a wide spectrum of clinical manifestations that are the result of an entangled contribution of host, immune and viral factors. The contribution of these factors is not completely established. Several investigations have described the involvement of the immune system in the viral control. In addition, distinct HLA-B alleles, HLA-B27, -B57-58, were associated with infection control. The combination of these elements and antiviral host restriction factors results in different clinical outcomes. The role of the viral proteins in HIV-1 infection has been, however, less investigated. We will review contributions dedicated to the pathogenesis of HIV-1 infection focusing on studies identifying the function of the viral envelope glycoprotein (Env) in the clinical progression because of its essential role in the initial events of the virus life-cycle. Some analysis showed that inefficient viral Envs were dominant in non-progressor individuals. These poorly-functional viral proteins resulted in lower cellular activation, viral replication and minor viral loads. This limited viral antigenic production allows a better immune response and a lower immune exhaustion. Thus, the properties of HIV-1 Env are significant in the clinical outcome of the HIV-1 infection and AIDS pathogenesis." @default.
- W4294989805 created "2022-09-09" @default.
- W4294989805 creator A5010770207 @default.
- W4294989805 creator A5014643751 @default.
- W4294989805 creator A5017595807 @default.
- W4294989805 creator A5041261266 @default.
- W4294989805 creator A5044612324 @default.
- W4294989805 creator A5049551235 @default.
- W4294989805 creator A5059818556 @default.
- W4294989805 creator A5061590425 @default.
- W4294989805 creator A5070798766 @default.
- W4294989805 creator A5081669122 @default.
- W4294989805 creator A5084391105 @default.
- W4294989805 creator A5088003575 @default.
- W4294989805 date "2022-09-02" @default.
- W4294989805 modified "2023-10-17" @default.
- W4294989805 title "Contribution of the HIV-1 Envelope Glycoprotein to AIDS Pathogenesis and Clinical Progression" @default.
- W4294989805 cites W1510731214 @default.
- W4294989805 cites W1521671672 @default.
- W4294989805 cites W1574561647 @default.
- W4294989805 cites W1608236599 @default.
- W4294989805 cites W1767363304 @default.
- W4294989805 cites W1923928177 @default.
- W4294989805 cites W1963984954 @default.
- W4294989805 cites W1965019797 @default.
- W4294989805 cites W1965346427 @default.
- W4294989805 cites W1968193348 @default.
- W4294989805 cites W1969955685 @default.
- W4294989805 cites W1970640392 @default.
- W4294989805 cites W1971057735 @default.
- W4294989805 cites W1971777539 @default.
- W4294989805 cites W1974477822 @default.
- W4294989805 cites W1976466060 @default.
- W4294989805 cites W1978217124 @default.
- W4294989805 cites W1978383659 @default.
- W4294989805 cites W1981164507 @default.
- W4294989805 cites W1985471077 @default.
- W4294989805 cites W1986371227 @default.
- W4294989805 cites W1986574361 @default.
- W4294989805 cites W1987600691 @default.
- W4294989805 cites W1989986600 @default.
- W4294989805 cites W1990651643 @default.
- W4294989805 cites W1991658724 @default.
- W4294989805 cites W1992991204 @default.
- W4294989805 cites W1996024432 @default.
- W4294989805 cites W1998541327 @default.
- W4294989805 cites W2000671553 @default.
- W4294989805 cites W2001815433 @default.
- W4294989805 cites W2002574877 @default.
- W4294989805 cites W2002915433 @default.
- W4294989805 cites W2003823192 @default.
- W4294989805 cites W2005428335 @default.
- W4294989805 cites W2005721902 @default.
- W4294989805 cites W2006694708 @default.
- W4294989805 cites W2007021820 @default.
- W4294989805 cites W2007941996 @default.
- W4294989805 cites W2010094066 @default.
- W4294989805 cites W2012139740 @default.
- W4294989805 cites W2012659064 @default.
- W4294989805 cites W2016296837 @default.
- W4294989805 cites W2016582810 @default.
- W4294989805 cites W2017551575 @default.
- W4294989805 cites W2019559865 @default.
- W4294989805 cites W2023285589 @default.
- W4294989805 cites W2024410915 @default.
- W4294989805 cites W2026444780 @default.
- W4294989805 cites W2026814484 @default.
- W4294989805 cites W2027054583 @default.
- W4294989805 cites W2028205504 @default.
- W4294989805 cites W2031576551 @default.
- W4294989805 cites W2034053987 @default.
- W4294989805 cites W2035608448 @default.
- W4294989805 cites W2037343680 @default.
- W4294989805 cites W2040679107 @default.
- W4294989805 cites W2040900515 @default.
- W4294989805 cites W2041816341 @default.
- W4294989805 cites W2041982728 @default.
- W4294989805 cites W2042815830 @default.
- W4294989805 cites W2043683168 @default.
- W4294989805 cites W2044816496 @default.
- W4294989805 cites W2048030072 @default.
- W4294989805 cites W2049355625 @default.
- W4294989805 cites W2052833798 @default.
- W4294989805 cites W2054309241 @default.
- W4294989805 cites W2055280854 @default.
- W4294989805 cites W2055379037 @default.
- W4294989805 cites W2058330143 @default.
- W4294989805 cites W2062148688 @default.
- W4294989805 cites W2064930458 @default.
- W4294989805 cites W2065486749 @default.
- W4294989805 cites W2069815189 @default.
- W4294989805 cites W2073618053 @default.
- W4294989805 cites W2074454030 @default.
- W4294989805 cites W2074918485 @default.
- W4294989805 cites W2076284523 @default.
- W4294989805 cites W2076366830 @default.
- W4294989805 cites W2079280846 @default.
- W4294989805 cites W2079429316 @default.