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- W4294989894 endingPage "2169" @default.
- W4294989894 startingPage "2169" @default.
- W4294989894 abstract "The with-no-lysine (WNK) kinase family, comprising four serine-threonine protein kinases (WNK1-4), were first linked to hypertension due to their mutations in association with pseudohypoaldosteronism type II (PHAII). WNK kinases regulate crucial blood pressure regulators, SPAK/OSR1, to mediate the post-translational modifications (PTMs) of their downstream ion channel substrates, such as sodium chloride co-transporter (NCC), epithelial sodium chloride (ENaC), renal outer medullary potassium channel (ROMK), and Na/K/2Cl co-transporters (NKCCs). In this review, we summarize the molecular pathways dysregulating the WNKs and their downstream target renal ion transporters. We summarize each of the genetic variants of WNK kinases and the small molecule inhibitors that have been discovered to regulate blood pressure via WNK-triggered PTM cascades." @default.
- W4294989894 created "2022-09-09" @default.
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- W4294989894 creator A5080047113 @default.
- W4294989894 date "2022-09-02" @default.
- W4294989894 modified "2023-10-18" @default.
- W4294989894 title "The Post-Translational Modification Networking in WNK-Centric Hypertension Regulation and Electrolyte Homeostasis" @default.
- W4294989894 cites W1524424634 @default.
- W4294989894 cites W1532298521 @default.
- W4294989894 cites W1554826176 @default.
- W4294989894 cites W1582195464 @default.
- W4294989894 cites W1608189470 @default.
- W4294989894 cites W1842989244 @default.
- W4294989894 cites W1860619528 @default.
- W4294989894 cites W1963873811 @default.
- W4294989894 cites W1964042466 @default.
- W4294989894 cites W1964051744 @default.
- W4294989894 cites W1964485689 @default.
- W4294989894 cites W1965407415 @default.
- W4294989894 cites W1965775947 @default.
- W4294989894 cites W1967490910 @default.
- W4294989894 cites W1968813770 @default.
- W4294989894 cites W1968914300 @default.
- W4294989894 cites W1969536046 @default.
- W4294989894 cites W1971877828 @default.
- W4294989894 cites W1974914819 @default.
- W4294989894 cites W1975016763 @default.
- W4294989894 cites W1975983905 @default.
- W4294989894 cites W1976656734 @default.
- W4294989894 cites W1977518774 @default.
- W4294989894 cites W1977832158 @default.
- W4294989894 cites W1977965548 @default.
- W4294989894 cites W1979512288 @default.
- W4294989894 cites W1979699722 @default.
- W4294989894 cites W1980425497 @default.
- W4294989894 cites W1981054886 @default.
- W4294989894 cites W1981295957 @default.
- W4294989894 cites W1982498018 @default.
- W4294989894 cites W1984344010 @default.
- W4294989894 cites W1984479357 @default.
- W4294989894 cites W1985793100 @default.
- W4294989894 cites W1987514645 @default.
- W4294989894 cites W1988048162 @default.
- W4294989894 cites W1988257582 @default.
- W4294989894 cites W1989156208 @default.
- W4294989894 cites W1989291503 @default.
- W4294989894 cites W1989490275 @default.
- W4294989894 cites W1992614804 @default.
- W4294989894 cites W1993468111 @default.
- W4294989894 cites W1995826486 @default.
- W4294989894 cites W1996108897 @default.
- W4294989894 cites W1996131559 @default.
- W4294989894 cites W1996856159 @default.
- W4294989894 cites W2000448320 @default.
- W4294989894 cites W2004706099 @default.
- W4294989894 cites W2004962180 @default.
- W4294989894 cites W2004970918 @default.
- W4294989894 cites W2005183176 @default.
- W4294989894 cites W2006423155 @default.
- W4294989894 cites W2007555006 @default.
- W4294989894 cites W2010733391 @default.
- W4294989894 cites W2013610439 @default.
- W4294989894 cites W2015344956 @default.
- W4294989894 cites W2016158080 @default.
- W4294989894 cites W2017401466 @default.
- W4294989894 cites W2018154888 @default.
- W4294989894 cites W2018462584 @default.
- W4294989894 cites W2018978933 @default.
- W4294989894 cites W2019120014 @default.
- W4294989894 cites W2019326144 @default.
- W4294989894 cites W2020435311 @default.
- W4294989894 cites W2020564204 @default.
- W4294989894 cites W2020620553 @default.
- W4294989894 cites W2023319730 @default.
- W4294989894 cites W2023483037 @default.
- W4294989894 cites W2024509859 @default.
- W4294989894 cites W2027532701 @default.
- W4294989894 cites W2027895266 @default.
- W4294989894 cites W2028053979 @default.
- W4294989894 cites W2030739173 @default.
- W4294989894 cites W2038617558 @default.
- W4294989894 cites W2039456047 @default.
- W4294989894 cites W2042109414 @default.
- W4294989894 cites W2042218708 @default.
- W4294989894 cites W2044485703 @default.
- W4294989894 cites W2047304768 @default.
- W4294989894 cites W2049095669 @default.
- W4294989894 cites W2051022720 @default.