Matches in SemOpenAlex for { <https://semopenalex.org/work/W4294991876> ?p ?o ?g. }
- W4294991876 endingPage "5180" @default.
- W4294991876 startingPage "5165" @default.
- W4294991876 abstract "Atherosclerosis is a complex pathological process involving macrophages, endothelial cells and vascular smooth muscle cells that can lead to ischemic heart disease; however, the mechanisms underlying cell-to-cell communication in atherosclerosis are poorly understood. In this study, we focused on the role of exosomal miRNAs in crosstalk between macrophages and endothelial cells and explored the rarely studied molecular mechanisms involved. Our in vitro result showed that macrophage-derived exosomal miR-4532 significantly disrupted human umbilical vein endothelial cells (HUVECs) function by targeting SP1 and downstream NF-κB P65 activation. In turn, increased endothelin-1 (ET-1), intercellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and decreased endothelial nitric oxide synthase (eNOS) expression in HUVECs increased attraction of macrophages, exacerbating foam cell formation and transfer of exosomal miR-4532 to HUVECs. MiR-4532 overexpression significantly promoted endothelial injury and pretreatment with an inhibitor of miR-4532 or GW4869 (exosome inhibitor) could reverse this injury. In conclusion, our data reveal that exosomes have a critical role in crosstalk between HUVECs and macrophages. Further, exosomal miR-4532 transferred from macrophages to HUVECs and targeting specificity protein 1 (SP1) may be a novel therapeutic target in patients with atherosclerosis." @default.
- W4294991876 created "2022-09-09" @default.
- W4294991876 creator A5005253551 @default.
- W4294991876 creator A5013007023 @default.
- W4294991876 creator A5018814025 @default.
- W4294991876 creator A5029740323 @default.
- W4294991876 creator A5042762548 @default.
- W4294991876 creator A5048418763 @default.
- W4294991876 creator A5049692788 @default.
- W4294991876 creator A5056116658 @default.
- W4294991876 creator A5060494556 @default.
- W4294991876 creator A5073216396 @default.
- W4294991876 creator A5077696966 @default.
- W4294991876 date "2022-09-07" @default.
- W4294991876 modified "2023-10-09" @default.
- W4294991876 title "Macrophage‐derived exosomal <scp>miR</scp>‐4532 promotes endothelial cells injury by targeting <scp>SP1</scp> and <scp>NF‐κB P65</scp> signalling activation" @default.
- W4294991876 cites W2016556817 @default.
- W4294991876 cites W2031561983 @default.
- W4294991876 cites W2040808310 @default.
- W4294991876 cites W2081215204 @default.
- W4294991876 cites W2096595306 @default.
- W4294991876 cites W2125596540 @default.
- W4294991876 cites W2153670033 @default.
- W4294991876 cites W2277540550 @default.
- W4294991876 cites W2280289381 @default.
- W4294991876 cites W2484838094 @default.
- W4294991876 cites W2603510655 @default.
- W4294991876 cites W2699220065 @default.
- W4294991876 cites W2793107094 @default.
- W4294991876 cites W2802855866 @default.
- W4294991876 cites W2805987990 @default.
- W4294991876 cites W2883158371 @default.
- W4294991876 cites W2905181679 @default.
- W4294991876 cites W2929617986 @default.
- W4294991876 cites W2942368772 @default.
- W4294991876 cites W2944571645 @default.
- W4294991876 cites W2970329437 @default.
- W4294991876 cites W2980258469 @default.
- W4294991876 cites W2981097353 @default.
- W4294991876 cites W2990791077 @default.
- W4294991876 cites W3000244508 @default.
- W4294991876 cites W3005104290 @default.
- W4294991876 cites W3005368336 @default.
- W4294991876 cites W3013086538 @default.
- W4294991876 cites W3015284544 @default.
- W4294991876 cites W3032416462 @default.
- W4294991876 cites W3042217302 @default.
- W4294991876 cites W3092527520 @default.
- W4294991876 cites W3092664101 @default.
- W4294991876 cites W3099983747 @default.
- W4294991876 cites W3106805418 @default.
- W4294991876 cites W3111987591 @default.
- W4294991876 cites W3115486082 @default.
- W4294991876 cites W3121181933 @default.
- W4294991876 cites W3134285277 @default.
- W4294991876 cites W3151765145 @default.
- W4294991876 cites W3197073530 @default.
- W4294991876 cites W4206604574 @default.
- W4294991876 cites W4206918029 @default.
- W4294991876 cites W4210424536 @default.
- W4294991876 cites W4211134725 @default.
- W4294991876 cites W4249579699 @default.
- W4294991876 cites W4294991876 @default.
- W4294991876 doi "https://doi.org/10.1111/jcmm.17541" @default.
- W4294991876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36071548" @default.
- W4294991876 hasPublicationYear "2022" @default.
- W4294991876 type Work @default.
- W4294991876 citedByCount "7" @default.
- W4294991876 countsByYear W42949918762022 @default.
- W4294991876 countsByYear W42949918762023 @default.
- W4294991876 crossrefType "journal-article" @default.
- W4294991876 hasAuthorship W4294991876A5005253551 @default.
- W4294991876 hasAuthorship W4294991876A5013007023 @default.
- W4294991876 hasAuthorship W4294991876A5018814025 @default.
- W4294991876 hasAuthorship W4294991876A5029740323 @default.
- W4294991876 hasAuthorship W4294991876A5042762548 @default.
- W4294991876 hasAuthorship W4294991876A5048418763 @default.
- W4294991876 hasAuthorship W4294991876A5049692788 @default.
- W4294991876 hasAuthorship W4294991876A5056116658 @default.
- W4294991876 hasAuthorship W4294991876A5060494556 @default.
- W4294991876 hasAuthorship W4294991876A5073216396 @default.
- W4294991876 hasAuthorship W4294991876A5077696966 @default.
- W4294991876 hasBestOaLocation W42949918761 @default.
- W4294991876 hasConcept C104317684 @default.
- W4294991876 hasConcept C123012128 @default.
- W4294991876 hasConcept C145059251 @default.
- W4294991876 hasConcept C16224149 @default.
- W4294991876 hasConcept C185592680 @default.
- W4294991876 hasConcept C202751555 @default.
- W4294991876 hasConcept C20518536 @default.
- W4294991876 hasConcept C2777411675 @default.
- W4294991876 hasConcept C2781261824 @default.
- W4294991876 hasConcept C55493867 @default.
- W4294991876 hasConcept C86803240 @default.
- W4294991876 hasConcept C95444343 @default.
- W4294991876 hasConceptScore W4294991876C104317684 @default.
- W4294991876 hasConceptScore W4294991876C123012128 @default.
- W4294991876 hasConceptScore W4294991876C145059251 @default.