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• W4294992940 abstract "Abstract Exposure to a diet with a high saturated fat content can influence the characteristics of the gastrointestinal tract, causing losses in the absorption of nutrients and favoring the appearance of diseases. The objective was to assess the effects of a high-fat diet (HFD) in the perinatal (pregnancy and lactation) and post-weaning period on the histomorphometry, neuroplasticity, and histopathology of the ileum. Wistar rats were divided into four subgroups: Control/Control (CC, n = 10) rats fed a control diet (C) throughout the trial period; Control/HFD (CH, n = 9) rats fed diet C (perinatal) and HFD after weaning; HFD/Control (HC, n = 10) rats fed HFD (perinatal) and diet C (post-weaning); HFD/HFD (HH, n = 9) rats fed HFD throughout the experimental period. There was atrophy of the Ileum wall with a reduction in the muscular tunic, submucosa, and mucosa thickness in the HH group of 37%, 28%, and 46%, respectively ( p < 0.0001). The depth of the crypts decreased by 29% ( p < 0.0001) and height increased by 5% ( p < 0.0013). Villus height decreased by 41% and 18% in HH and HC groups ( p < 0.0001) and width decreased by 11% in the HH ( p < 0.0001). The height of the enterocytes decreased by 18% in the HH ( p < 0.0001). There was a decrease in the area of the myenteric and submucosal plexus ganglia in the HH and HC groups ( p < 0.0001). The number, occupation, and granules of Paneth cells increased in the HH and HC groups ( p < 0.0001). Intraepithelial lymphocytes (IELs) increased in all groups exposed to the HFD. Goblet cells decreased in groups CH and HH ( p < 0.0001). The evidence from this study suggests that the HFD had altered the histomorphometry, neuroplasticity, and histopathology of the ileum of the rats." @default.
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• W4294992940 date "2022-09-08" @default.
• W4294992940 modified "2023-10-06" @default.
• W4294992940 title "Perinatal and post-weaning exposure to a high-fat diet causes histomorphometric, neuroplastic, and histopathological changes in the rat ileum" @default.
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• W4294992940 doi "https://doi.org/10.1017/s2040174422000514" @default.
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