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- W4295006260 abstract "Histoplasmosis remains a challenging infection in solid organ transplantation. This review provides a topic update with emphasis on the changing Histoplasma epidemiology, along with new diagnostic and treatment innovations. Recent years have observed expanding Histoplasma geographic distribution due to climate change, environmental disruption, and host factors. Early clinical experience also suggests a relationship between COVID-19 infection and histoplasmosis, particularly among immunocompromised individuals. Advances in diagnostic methods, such as newer enzyme immunoassays and molecular techniques, have broadened the capability for expedient and highly specific pathogen identification. Novel drug innovations, including the development of new formulations of existing antifungal agents, extended-spectrum azoles and new antifungal drug classes have expanded therapeutic options. Advances in organ transplantation have largely outpaced those for histoplasmosis. However, these emerging insights enhance our understanding of this pathogen and management of clinical infection, particularly for transplant recipients with a higher incidence and severity of disease." @default.
- W4295006260 created "2022-09-09" @default.
- W4295006260 creator A5055568963 @default.
- W4295006260 creator A5070541391 @default.
- W4295006260 date "2022-09-08" @default.
- W4295006260 modified "2023-10-18" @default.
- W4295006260 title "Updates on Histoplasmosis in Solid Organ Transplantation" @default.
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- W4295006260 doi "https://doi.org/10.1007/s12281-022-00441-1" @default.
- W4295006260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36097519" @default.
- W4295006260 hasPublicationYear "2022" @default.
- W4295006260 type Work @default.