Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295007351> ?p ?o ?g. }
- W4295007351 endingPage "1896" @default.
- W4295007351 startingPage "1896" @default.
- W4295007351 abstract "Exposure to ultraviolet B (UVB) leads to the overproduction of reactive oxygen species (ROS), causing higher risks of skin disorders. Luteolin (Lut) is a naturally occurring antioxidant that can absorb a broad range of ultraviolet light, but its water solubility and skin permeability are limited and insufficient. The aim of the current study was to develop a Lut-loaded self-emulsifying phospholipid preconcentrate (LSEPP) for enhancing the solubility, permeability, and photoprotective activity of Lut. The designed formulations were firstly examined for their droplet size, zeta potential, dispersity, and in vitro corneum permeability after dispensing the preconcentrate to form an emulsion; the optimized formulation was further characterized for its emulsified morphology, compatibility with excipients, stability in the preconcentrate form, and photoprotective activity by the HaCaT cell model under the emulsified status. The optimized LSEPP formulation attained a smaller droplet size (140.6 ± 24.2 nm) with the addition of 1,8-cineole and increased the permeability of Lut by 7-fold. As evidenced in the cell model studies, the optimized LSEPP formulation can efficiently deliver Lut into HaCaT cells after emulsification and result in a 115% better cell viability as well as a 203% stronger ROS scavenging capability, compared with those of unformulated Lut after UVB irradiation. To sum up, we have successfully developed an LSEPP formulation, which is a safe and promising topical delivery system for enhancing the photoprotective effects of Lut." @default.
- W4295007351 created "2022-09-09" @default.
- W4295007351 creator A5014164054 @default.
- W4295007351 creator A5019281910 @default.
- W4295007351 creator A5036054707 @default.
- W4295007351 creator A5051894715 @default.
- W4295007351 creator A5082069594 @default.
- W4295007351 date "2022-09-07" @default.
- W4295007351 modified "2023-10-18" @default.
- W4295007351 title "Self-Emulsifying Phospholipid Preconcentrates for the Enhanced Photoprotection of Luteolin" @default.
- W4295007351 cites W1484126258 @default.
- W4295007351 cites W1550353272 @default.
- W4295007351 cites W1574232436 @default.
- W4295007351 cites W1894396911 @default.
- W4295007351 cites W1978124142 @default.
- W4295007351 cites W1982328592 @default.
- W4295007351 cites W2003620214 @default.
- W4295007351 cites W2004861590 @default.
- W4295007351 cites W2015556604 @default.
- W4295007351 cites W2015980482 @default.
- W4295007351 cites W2031464787 @default.
- W4295007351 cites W2045499291 @default.
- W4295007351 cites W2050890076 @default.
- W4295007351 cites W2073401195 @default.
- W4295007351 cites W2074223421 @default.
- W4295007351 cites W2090283144 @default.
- W4295007351 cites W2091803992 @default.
- W4295007351 cites W2091838928 @default.
- W4295007351 cites W2123454317 @default.
- W4295007351 cites W2133061356 @default.
- W4295007351 cites W2134134853 @default.
- W4295007351 cites W2310216621 @default.
- W4295007351 cites W2486388873 @default.
- W4295007351 cites W2522355042 @default.
- W4295007351 cites W2599052410 @default.
- W4295007351 cites W2697871094 @default.
- W4295007351 cites W2769077896 @default.
- W4295007351 cites W2769645593 @default.
- W4295007351 cites W2785827727 @default.
- W4295007351 cites W2792266918 @default.
- W4295007351 cites W2800910258 @default.
- W4295007351 cites W2804618706 @default.
- W4295007351 cites W2912875539 @default.
- W4295007351 cites W2952884998 @default.
- W4295007351 cites W2955527856 @default.
- W4295007351 cites W3002852220 @default.
- W4295007351 cites W3006107084 @default.
- W4295007351 cites W3013685769 @default.
- W4295007351 cites W3032860922 @default.
- W4295007351 cites W3033524992 @default.
- W4295007351 cites W3044828380 @default.
- W4295007351 cites W3103420300 @default.
- W4295007351 cites W3111144192 @default.
- W4295007351 cites W3112290943 @default.
- W4295007351 cites W3139253162 @default.
- W4295007351 cites W3175441751 @default.
- W4295007351 cites W3183787061 @default.
- W4295007351 cites W3188021812 @default.
- W4295007351 cites W3194589535 @default.
- W4295007351 cites W3209392647 @default.
- W4295007351 cites W4200011819 @default.
- W4295007351 cites W4200176454 @default.
- W4295007351 cites W4205954557 @default.
- W4295007351 cites W4210631625 @default.
- W4295007351 cites W4214637702 @default.
- W4295007351 cites W4220907819 @default.
- W4295007351 cites W4226049460 @default.
- W4295007351 cites W4229081705 @default.
- W4295007351 doi "https://doi.org/10.3390/pharmaceutics14091896" @default.
- W4295007351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36145644" @default.
- W4295007351 hasPublicationYear "2022" @default.
- W4295007351 type Work @default.
- W4295007351 citedByCount "0" @default.
- W4295007351 crossrefType "journal-article" @default.
- W4295007351 hasAuthorship W4295007351A5014164054 @default.
- W4295007351 hasAuthorship W4295007351A5019281910 @default.
- W4295007351 hasAuthorship W4295007351A5036054707 @default.
- W4295007351 hasAuthorship W4295007351A5051894715 @default.
- W4295007351 hasAuthorship W4295007351A5082069594 @default.
- W4295007351 hasBestOaLocation W42950073511 @default.
- W4295007351 hasConcept C11432220 @default.
- W4295007351 hasConcept C118995209 @default.
- W4295007351 hasConcept C155672457 @default.
- W4295007351 hasConcept C171250308 @default.
- W4295007351 hasConcept C178790620 @default.
- W4295007351 hasConcept C183688256 @default.
- W4295007351 hasConcept C185592680 @default.
- W4295007351 hasConcept C192562407 @default.
- W4295007351 hasConcept C202751555 @default.
- W4295007351 hasConcept C2778004101 @default.
- W4295007351 hasConcept C2778123984 @default.
- W4295007351 hasConcept C2778918659 @default.
- W4295007351 hasConcept C2780542282 @default.
- W4295007351 hasConcept C41625074 @default.
- W4295007351 hasConcept C43617362 @default.
- W4295007351 hasConcept C53227056 @default.
- W4295007351 hasConcept C55493867 @default.
- W4295007351 hasConcept C86181022 @default.