FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295007788> ?p ?o ?g. }

• W4295007788 endingPage "1020" @default.
• W4295007788 startingPage "1020" @default.
• W4295007788 abstract "Arginase is a metalloenzyme that plays a central role in Leishmania infections. Previously, rosmarinic and caffeic acids were described as antileishmanial agents and as Leishmania amazonensis arginase inhibitors. Here, we describe the inhibition of arginase in L. amazonensis by rosmarinic acid analogs (1-7) and new caffeic acid-derived amides (8-10). Caffeic acid esters and amides were produced by means of an engineered synthesis in E. coli and tested against L. amazonensis arginase. New amides (8-10) were biosynthesized in E. coli cultured with 2 mM of different combinations of feeding substrates. The most potent arginase inhibitors showed Ki(s) ranging from 2 to 5.7 μM. Compounds 2-4 and 7 inhibited L. amazonensis arginase (L-ARG) through a noncompetitive mechanism whilst compound 9 showed a competitive inhibition. By applying an in silico protocol, we determined the binding mode of compound 9. The competitive inhibitor of L-ARG targeted the key residues within the binding site of the enzyme, establishing a metal coordination bond with the metal ions and a series of hydrophobic and polar contacts supporting its micromolar inhibition of L-ARG. These results highlight that dihydroxycinnamic-derived compounds can be used as the basis for developing new drugs using a powerful tool based on the biosynthesis of arginase inhibitors." @default.
• W4295007788 created "2022-09-09" @default.
• W4295007788 creator A5005586041 @default.
• W4295007788 creator A5013297039 @default.
• W4295007788 creator A5018433039 @default.
• W4295007788 creator A5036633970 @default.
• W4295007788 creator A5048296248 @default.
• W4295007788 creator A5060371306 @default.
• W4295007788 creator A5084867757 @default.
• W4295007788 date "2022-09-07" @default.
• W4295007788 modified "2023-10-17" @default.
• W4295007788 title "In Vitro and In Silico Analyses of New Cinnamid and Rosmarinic Acid-Derived Compounds Biosynthesized in Escherichia coli as Leishmania amazonensis Arginase Inhibitors" @default.
• W4295007788 cites W1225741233 @default.
• W4295007788 cites W1885778179 @default.
• W4295007788 cites W1972758026 @default.
• W4295007788 cites W1976499671 @default.
• W4295007788 cites W1991794210 @default.
• W4295007788 cites W1993341798 @default.
• W4295007788 cites W2000260834 @default.
• W4295007788 cites W2015022444 @default.
• W4295007788 cites W2015332195 @default.
• W4295007788 cites W2035687084 @default.
• W4295007788 cites W2046457128 @default.
• W4295007788 cites W2050366480 @default.
• W4295007788 cites W2051381895 @default.
• W4295007788 cites W2053821816 @default.
• W4295007788 cites W2054901225 @default.
• W4295007788 cites W2059299190 @default.
• W4295007788 cites W2063862054 @default.
• W4295007788 cites W2065815743 @default.
• W4295007788 cites W2070748062 @default.
• W4295007788 cites W2087503664 @default.
• W4295007788 cites W2108173186 @default.
• W4295007788 cites W2117541362 @default.
• W4295007788 cites W2148686101 @default.
• W4295007788 cites W2168534750 @default.
• W4295007788 cites W2199848128 @default.
• W4295007788 cites W2273445276 @default.
• W4295007788 cites W2336093037 @default.
• W4295007788 cites W2340940993 @default.
• W4295007788 cites W2525658327 @default.
• W4295007788 cites W2563778632 @default.
• W4295007788 cites W2782868075 @default.
• W4295007788 cites W2890025130 @default.
• W4295007788 cites W2945780266 @default.
• W4295007788 cites W2966113770 @default.
• W4295007788 cites W2990882533 @default.
• W4295007788 cites W3026550608 @default.
• W4295007788 cites W3105318008 @default.
• W4295007788 cites W3138798301 @default.
• W4295007788 doi "https://doi.org/10.3390/pathogens11091020" @default.
• W4295007788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36145452" @default.
• W4295007788 hasPublicationYear "2022" @default.
• W4295007788 type Work @default.
• W4295007788 citedByCount "2" @default.
• W4295007788 countsByYear W42950077882023 @default.
• W4295007788 crossrefType "journal-article" @default.
• W4295007788 hasAuthorship W4295007788A5005586041 @default.
• W4295007788 hasAuthorship W4295007788A5013297039 @default.
• W4295007788 hasAuthorship W4295007788A5018433039 @default.
• W4295007788 hasAuthorship W4295007788A5036633970 @default.
• W4295007788 hasAuthorship W4295007788A5048296248 @default.
• W4295007788 hasAuthorship W4295007788A5060371306 @default.
• W4295007788 hasAuthorship W4295007788A5084867757 @default.
• W4295007788 hasBestOaLocation W42950077881 @default.
• W4295007788 hasConcept C104317684 @default.
• W4295007788 hasConcept C136764020 @default.
• W4295007788 hasConcept C150757390 @default.
• W4295007788 hasConcept C164007495 @default.
• W4295007788 hasConcept C181199279 @default.
• W4295007788 hasConcept C185592680 @default.
• W4295007788 hasConcept C2775905019 @default.
• W4295007788 hasConcept C2777468819 @default.
• W4295007788 hasConcept C2778004101 @default.
• W4295007788 hasConcept C2778224086 @default.
• W4295007788 hasConcept C2778771215 @default.
• W4295007788 hasConcept C2781092759 @default.
• W4295007788 hasConcept C41008148 @default.
• W4295007788 hasConcept C515207424 @default.
• W4295007788 hasConcept C547475151 @default.
• W4295007788 hasConcept C55493867 @default.
• W4295007788 hasConcept C71928629 @default.
• W4295007788 hasConcept C86803240 @default.
• W4295007788 hasConceptScore W4295007788C104317684 @default.
• W4295007788 hasConceptScore W4295007788C136764020 @default.
• W4295007788 hasConceptScore W4295007788C150757390 @default.
• W4295007788 hasConceptScore W4295007788C164007495 @default.
• W4295007788 hasConceptScore W4295007788C181199279 @default.
• W4295007788 hasConceptScore W4295007788C185592680 @default.
• W4295007788 hasConceptScore W4295007788C2775905019 @default.
• W4295007788 hasConceptScore W4295007788C2777468819 @default.
• W4295007788 hasConceptScore W4295007788C2778004101 @default.
• W4295007788 hasConceptScore W4295007788C2778224086 @default.
• W4295007788 hasConceptScore W4295007788C2778771215 @default.
• W4295007788 hasConceptScore W4295007788C2781092759 @default.
• W4295007788 hasConceptScore W4295007788C41008148 @default.
• W4295007788 hasConceptScore W4295007788C515207424 @default.
• W4295007788 hasConceptScore W4295007788C547475151 @default.

• next