Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295012015> ?p ?o ?g. }
- W4295012015 abstract "Abstract Despite the availability of vaccines and approved therapeutics, the COVID-19 pandemic continues to rise owing to the emergence of newer variants. Several multi-omics studies have made available extensive evidence on host-pathogen interactions and potential therapeutic targets. Nonetheless, an increased understanding of host signaling networks regulated by post-translational modifications and their ensuing effect on the biochemical and cellular dynamics is critical to expanding the current knowledge on the host response to SARS-CoV-2 infections. Here, employing unbiased global transcriptomics, proteomics, acetylomics, phosphoproteomics, and exometabolome analysis of a lung-derived human cell line, we show that SARS-CoV-2 Norway/Trondheim-S15 strain induces time-dependent alterations in the induction of type I IFN response, activation of DNA damage response, dysregulated Hippo signaling, among others. We provide evidence for the interplay of phosphorylation and acetylation dynamics on host proteins and its effect on the altered release of metabolites, especially organic acids and ketone bodies. Together, our findings serve as a resource of potential targets that can aid in designing novel host-directed therapeutic strategies." @default.
- W4295012015 created "2022-09-09" @default.
- W4295012015 creator A5018334758 @default.
- W4295012015 creator A5019343237 @default.
- W4295012015 creator A5021161802 @default.
- W4295012015 creator A5031006818 @default.
- W4295012015 creator A5043950581 @default.
- W4295012015 creator A5047962941 @default.
- W4295012015 creator A5063293987 @default.
- W4295012015 creator A5077501248 @default.
- W4295012015 creator A5083127295 @default.
- W4295012015 creator A5086167954 @default.
- W4295012015 date "2022-09-07" @default.
- W4295012015 modified "2023-10-18" @default.
- W4295012015 title "MultiOMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells" @default.
- W4295012015 cites W1491225930 @default.
- W4295012015 cites W1963272969 @default.
- W4295012015 cites W1964684831 @default.
- W4295012015 cites W1970629672 @default.
- W4295012015 cites W1972399884 @default.
- W4295012015 cites W1976555683 @default.
- W4295012015 cites W1983371173 @default.
- W4295012015 cites W1993591244 @default.
- W4295012015 cites W1995013322 @default.
- W4295012015 cites W2011121500 @default.
- W4295012015 cites W2012441269 @default.
- W4295012015 cites W2014089999 @default.
- W4295012015 cites W2020511240 @default.
- W4295012015 cites W2027340130 @default.
- W4295012015 cites W2027363067 @default.
- W4295012015 cites W2035975883 @default.
- W4295012015 cites W2037199116 @default.
- W4295012015 cites W2038163496 @default.
- W4295012015 cites W2040932281 @default.
- W4295012015 cites W2055844410 @default.
- W4295012015 cites W2058730913 @default.
- W4295012015 cites W2076890866 @default.
- W4295012015 cites W2083060592 @default.
- W4295012015 cites W2086897927 @default.
- W4295012015 cites W2089140732 @default.
- W4295012015 cites W2096409608 @default.
- W4295012015 cites W2099709490 @default.
- W4295012015 cites W2123450550 @default.
- W4295012015 cites W2148407128 @default.
- W4295012015 cites W2152595005 @default.
- W4295012015 cites W2158542519 @default.
- W4295012015 cites W2162730852 @default.
- W4295012015 cites W2168636113 @default.
- W4295012015 cites W2169456326 @default.
- W4295012015 cites W2178562114 @default.
- W4295012015 cites W2179438025 @default.
- W4295012015 cites W2278032859 @default.
- W4295012015 cites W2298917269 @default.
- W4295012015 cites W2309366384 @default.
- W4295012015 cites W2406250479 @default.
- W4295012015 cites W2418024629 @default.
- W4295012015 cites W2502710489 @default.
- W4295012015 cites W2544156495 @default.
- W4295012015 cites W2605460970 @default.
- W4295012015 cites W2613997270 @default.
- W4295012015 cites W2734356283 @default.
- W4295012015 cites W2753698002 @default.
- W4295012015 cites W2794734792 @default.
- W4295012015 cites W2803664483 @default.
- W4295012015 cites W2886755207 @default.
- W4295012015 cites W2886968113 @default.
- W4295012015 cites W2903746377 @default.
- W4295012015 cites W2904372598 @default.
- W4295012015 cites W2909275889 @default.
- W4295012015 cites W2939219649 @default.
- W4295012015 cites W2943886226 @default.
- W4295012015 cites W2949830473 @default.
- W4295012015 cites W2951516225 @default.
- W4295012015 cites W2963402728 @default.
- W4295012015 cites W2965230527 @default.
- W4295012015 cites W2973448703 @default.
- W4295012015 cites W2997234557 @default.
- W4295012015 cites W3001118548 @default.
- W4295012015 cites W3009906937 @default.
- W4295012015 cites W3018023298 @default.
- W4295012015 cites W3021577931 @default.
- W4295012015 cites W3022285953 @default.
- W4295012015 cites W3024643080 @default.
- W4295012015 cites W3026002191 @default.
- W4295012015 cites W3027630905 @default.
- W4295012015 cites W3037945517 @default.
- W4295012015 cites W3039874336 @default.
- W4295012015 cites W3041477809 @default.
- W4295012015 cites W3045252049 @default.
- W4295012015 cites W3047880613 @default.
- W4295012015 cites W3081687852 @default.
- W4295012015 cites W3081724017 @default.
- W4295012015 cites W3082208207 @default.
- W4295012015 cites W3082379743 @default.
- W4295012015 cites W3084149299 @default.
- W4295012015 cites W3085062170 @default.
- W4295012015 cites W3085500933 @default.
- W4295012015 cites W3087334242 @default.
- W4295012015 cites W3092087377 @default.
- W4295012015 cites W3092519469 @default.