FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295012021> ?p ?o ?g. }

• W4295012021 abstract "Abstract It is becoming increasingly clear that antibiotics can both positively and negatively impact the infectivity of bacteriophages (phage), but the underlying mechanisms often remain unclear. Here we demonstrate that antibiotics that target the protein translation machinery can fundamentally alter the outcome of bacteria-phage interactions by interfering with the production of phage-encoded counter-defence proteins. Specifically, using Pseudomonas aeruginosa PA14 and phage DMS3vir as a model, we show that bacteria with CRISPR-Cas immune systems have elevated levels of immunity against phage that encode anti-CRISPR ( acr ) genes when translation inhibitors are present in the environment. CRISPR-Cas are highly prevalent defence systems that enable bacteria to detect and destroy phage genomes in a sequence-specific manner. In response, many phages encode acr genes that are expressed immediately following infection to inhibit key steps of the CRISPR-Cas immune response. Our data show that while phage carrying acr genes can amplify efficiently on bacteria with CRISPR-Cas immune systems in the absence of antibiotics, the presence of antibiotics that act on protein translation prevents phage amplification, while protecting bacteria from lysis. These results help to understand how antibiotics-phage synergy and antagonism depend on the molecular interactions that define phage infectivity and host immunity." @default.
• W4295012021 created "2022-09-09" @default.
• W4295012021 creator A5016084470 @default.
• W4295012021 creator A5036187910 @default.
• W4295012021 creator A5070135428 @default.
• W4295012021 creator A5086673009 @default.
• W4295012021 date "2022-09-07" @default.
• W4295012021 modified "2023-09-27" @default.
• W4295012021 title "Antibiotics that affect translation can antagonize phage infectivity by interfering with the deployment of counter-defences" @default.
• W4295012021 cites W1552724685 @default.
• W4295012021 cites W1970515032 @default.
• W4295012021 cites W1981124231 @default.
• W4295012021 cites W1985647584 @default.
• W4295012021 cites W2012200988 @default.
• W4295012021 cites W2019197162 @default.
• W4295012021 cites W2043083543 @default.
• W4295012021 cites W2048373752 @default.
• W4295012021 cites W2056589536 @default.
• W4295012021 cites W2062973856 @default.
• W4295012021 cites W2065149305 @default.
• W4295012021 cites W2078859026 @default.
• W4295012021 cites W2086402273 @default.
• W4295012021 cites W2086919865 @default.
• W4295012021 cites W2104276827 @default.
• W4295012021 cites W2104789794 @default.
• W4295012021 cites W2105750464 @default.
• W4295012021 cites W2155707781 @default.
• W4295012021 cites W2169244146 @default.
• W4295012021 cites W2194181707 @default.
• W4295012021 cites W2268559917 @default.
• W4295012021 cites W2274519180 @default.
• W4295012021 cites W2321779338 @default.
• W4295012021 cites W2338271148 @default.
• W4295012021 cites W2430331709 @default.
• W4295012021 cites W2465903376 @default.
• W4295012021 cites W2563408447 @default.
• W4295012021 cites W2616853239 @default.
• W4295012021 cites W2739018336 @default.
• W4295012021 cites W2791620675 @default.
• W4295012021 cites W2911362701 @default.
• W4295012021 cites W2912469688 @default.
• W4295012021 cites W2913871048 @default.
• W4295012021 cites W2915167646 @default.
• W4295012021 cites W2944743307 @default.
• W4295012021 cites W2951304989 @default.
• W4295012021 cites W2953305767 @default.
• W4295012021 cites W2963246688 @default.
• W4295012021 cites W2969792006 @default.
• W4295012021 cites W2970071674 @default.
• W4295012021 cites W2980100358 @default.
• W4295012021 cites W2984113873 @default.
• W4295012021 cites W2989135569 @default.
• W4295012021 cites W2989568248 @default.
• W4295012021 cites W2995081665 @default.
• W4295012021 cites W2998058312 @default.
• W4295012021 cites W2999639869 @default.
• W4295012021 cites W3011435240 @default.
• W4295012021 cites W3011910186 @default.
• W4295012021 cites W3091955023 @default.
• W4295012021 cites W3094065547 @default.
• W4295012021 cites W3163193325 @default.
• W4295012021 cites W3192943233 @default.
• W4295012021 cites W3213512519 @default.
• W4295012021 cites W4200182090 @default.
• W4295012021 cites W4229046765 @default.
• W4295012021 cites W4291964160 @default.
• W4295012021 doi "https://doi.org/10.1101/2022.09.07.506948" @default.
• W4295012021 hasPublicationYear "2022" @default.
• W4295012021 type Work @default.
• W4295012021 citedByCount "0" @default.
• W4295012021 crossrefType "posted-content" @default.
• W4295012021 hasAuthorship W4295012021A5016084470 @default.
• W4295012021 hasAuthorship W4295012021A5036187910 @default.
• W4295012021 hasAuthorship W4295012021A5070135428 @default.
• W4295012021 hasAuthorship W4295012021A5086673009 @default.
• W4295012021 hasBestOaLocation W42950120211 @default.
• W4295012021 hasConcept C10079403 @default.
• W4295012021 hasConcept C104317684 @default.
• W4295012021 hasConcept C105580179 @default.
• W4295012021 hasConcept C106358424 @default.
• W4295012021 hasConcept C149364088 @default.
• W4295012021 hasConcept C159047783 @default.
• W4295012021 hasConcept C2522874641 @default.
• W4295012021 hasConcept C2776441376 @default.
• W4295012021 hasConcept C501593827 @default.
• W4295012021 hasConcept C523546767 @default.
• W4295012021 hasConcept C54355233 @default.
• W4295012021 hasConcept C547475151 @default.
• W4295012021 hasConcept C70721500 @default.
• W4295012021 hasConcept C86803240 @default.
• W4295012021 hasConcept C8891405 @default.
• W4295012021 hasConcept C89423630 @default.
• W4295012021 hasConcept C98108389 @default.
• W4295012021 hasConceptScore W4295012021C10079403 @default.
• W4295012021 hasConceptScore W4295012021C104317684 @default.
• W4295012021 hasConceptScore W4295012021C105580179 @default.
• W4295012021 hasConceptScore W4295012021C106358424 @default.
• W4295012021 hasConceptScore W4295012021C149364088 @default.
• W4295012021 hasConceptScore W4295012021C159047783 @default.
• W4295012021 hasConceptScore W4295012021C2522874641 @default.

• next