FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295014927> ?p ?o ?g. }

• W4295014927 abstract "Numerous studies have been conducted to investigate the relationship between tea consumption and the risk of cardiovascular diseases (CVD); however, no conclusive results have been achieved. We conducted a Mendelian randomization (MR) study to elucidate the causal associations between tea consumption and several CVD outcomes, including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), and heart failure (HF).Independent single-nucleotide polymorphisms (SNPs) genome-wide significantly associated with tea consumption were used as instrumental variables (IVs). Summary statistics for CVD outcomes were obtained from the corresponding genetic consortia and the FinnGen consortium. The inverse-variance weighted (IVW) method was the primary analytical method, and MR estimates from different data sources were combined using fixed-effects meta-analysis. Supplementary MR analyses, including the weighted median, MR-Egger, and the MR pleiotropy residual sum and outlier methods, were conducted to evaluate the robustness of the results. Further MR analyses were repeated by including more genetic variants at a higher P-value threshold.We found that genetically predicted tea consumption was not causally associated with any CVD outcomes in the IVW method using data from large genetic consortia [CAD: odds ratio (OR) = 1.00, 95% confidence interval (CI), 0.91, 1.10, P = 0.997; MI: OR = 0.98, 95% CI, 0.90, 1.08, P = 0.751; AF: OR = 0.97, 95% CI, 0.92, 1.03, P = 0.350; HF: OR = 0.96, 95% CI, 0.88, 1.05, P = 0.401] or the FinnGen consortium (CAD: OR = 1.06, 95% CI, 0.96, 1.17, P = 0.225; MI: OR = 1.01, 95% CI, 0.89, 1.15, P = 0.882; AF: OR = 1.00, 95% CI, 0.88, 1.14, P = 0.994; HF: OR = 0.96, 95% CI, 0.88, 1.04, P = 0.362). The results were robust and consistent across meta-analysis, supplementary MR analyses, and analyses with more IVs included.This MR study revealed no causal association between tea consumption and four CVD outcomes, suggesting that tea consumption may not be beneficial for the primary prevention of CVD." @default.
• W4295014927 created "2022-09-09" @default.
• W4295014927 creator A5009407813 @default.
• W4295014927 creator A5014543848 @default.
• W4295014927 creator A5071074966 @default.
• W4295014927 date "2022-09-07" @default.
• W4295014927 modified "2023-09-30" @default.
• W4295014927 title "No causal effect of tea consumption on cardiovascular diseases: A two-sample Mendelian randomization study" @default.
• W4295014927 cites W1946815265 @default.
• W4295014927 cites W1966599364 @default.
• W4295014927 cites W1972696558 @default.
• W4295014927 cites W1979136832 @default.
• W4295014927 cites W1980213584 @default.
• W4295014927 cites W2017129618 @default.
• W4295014927 cites W2042421971 @default.
• W4295014927 cites W2063230331 @default.
• W4295014927 cites W2104549677 @default.
• W4295014927 cites W2109478483 @default.
• W4295014927 cites W2112203259 @default.
• W4295014927 cites W2113699335 @default.
• W4295014927 cites W2115252902 @default.
• W4295014927 cites W2121994801 @default.
• W4295014927 cites W2124768821 @default.
• W4295014927 cites W2156848121 @default.
• W4295014927 cites W2161623426 @default.
• W4295014927 cites W2171477413 @default.
• W4295014927 cites W2196906371 @default.
• W4295014927 cites W2238851414 @default.
• W4295014927 cites W2324862792 @default.
• W4295014927 cites W2464229192 @default.
• W4295014927 cites W2520048741 @default.
• W4295014927 cites W2520175901 @default.
• W4295014927 cites W2523264763 @default.
• W4295014927 cites W2537846612 @default.
• W4295014927 cites W2581245397 @default.
• W4295014927 cites W2592520729 @default.
• W4295014927 cites W2609543937 @default.
• W4295014927 cites W2793368865 @default.
• W4295014927 cites W2803072880 @default.
• W4295014927 cites W2805983714 @default.
• W4295014927 cites W2812742579 @default.
• W4295014927 cites W2884743521 @default.
• W4295014927 cites W2905663314 @default.
• W4295014927 cites W2986365660 @default.
• W4295014927 cites W2999230481 @default.
• W4295014927 cites W3005124854 @default.
• W4295014927 cites W3084042125 @default.
• W4295014927 cites W3107270371 @default.
• W4295014927 cites W3139974943 @default.
• W4295014927 cites W3198456141 @default.
• W4295014927 cites W3202069842 @default.
• W4295014927 cites W3206313297 @default.
• W4295014927 cites W3210570897 @default.
• W4295014927 doi "https://doi.org/10.3389/fcvm.2022.870972" @default.
• W4295014927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36158846" @default.
• W4295014927 hasPublicationYear "2022" @default.
• W4295014927 type Work @default.
• W4295014927 citedByCount "0" @default.
• W4295014927 crossrefType "journal-article" @default.
• W4295014927 hasAuthorship W4295014927A5009407813 @default.
• W4295014927 hasAuthorship W4295014927A5014543848 @default.
• W4295014927 hasAuthorship W4295014927A5071074966 @default.
• W4295014927 hasBestOaLocation W42950149271 @default.
• W4295014927 hasConcept C104317684 @default.
• W4295014927 hasConcept C126322002 @default.
• W4295014927 hasConcept C135763542 @default.
• W4295014927 hasConcept C153209595 @default.
• W4295014927 hasConcept C156957248 @default.
• W4295014927 hasConcept C164705383 @default.
• W4295014927 hasConcept C2778213512 @default.
• W4295014927 hasConcept C2779901538 @default.
• W4295014927 hasConcept C2993967602 @default.
• W4295014927 hasConcept C44249647 @default.
• W4295014927 hasConcept C500558357 @default.
• W4295014927 hasConcept C54355233 @default.
• W4295014927 hasConcept C71924100 @default.
• W4295014927 hasConcept C86803240 @default.
• W4295014927 hasConceptScore W4295014927C104317684 @default.
• W4295014927 hasConceptScore W4295014927C126322002 @default.
• W4295014927 hasConceptScore W4295014927C135763542 @default.
• W4295014927 hasConceptScore W4295014927C153209595 @default.
• W4295014927 hasConceptScore W4295014927C156957248 @default.
• W4295014927 hasConceptScore W4295014927C164705383 @default.
• W4295014927 hasConceptScore W4295014927C2778213512 @default.
• W4295014927 hasConceptScore W4295014927C2779901538 @default.
• W4295014927 hasConceptScore W4295014927C2993967602 @default.
• W4295014927 hasConceptScore W4295014927C44249647 @default.
• W4295014927 hasConceptScore W4295014927C500558357 @default.
• W4295014927 hasConceptScore W4295014927C54355233 @default.
• W4295014927 hasConceptScore W4295014927C71924100 @default.
• W4295014927 hasConceptScore W4295014927C86803240 @default.
• W4295014927 hasFunder F4320321001 @default.
• W4295014927 hasLocation W42950149271 @default.
• W4295014927 hasLocation W42950149272 @default.
• W4295014927 hasLocation W42950149273 @default.
• W4295014927 hasLocation W42950149274 @default.
• W4295014927 hasOpenAccess W4295014927 @default.
• W4295014927 hasPrimaryLocation W42950149271 @default.
• W4295014927 hasRelatedWork W2008477804 @default.
• W4295014927 hasRelatedWork W2149494111 @default.

• next