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- W4295015124 abstract "Cell assemblies are considered fundamental units of brain activity, underlying diverse functions ranging from perception to memory and decision-making. Cell assemblies have historically been theorized as internal representations of specific stimuli or actions. Alternatively, cell assemblies can be defined without reference to an external world, by their endogenous ability to effectively elicit specific responses in downstream (‘reader’) neurons. However, this compelling framework currently lacks experimental support. Here, we provide evidence for assembly– reader communication. Reader activation was genuinely collective, functionally selective, yet flexible, implementing both pattern separation and completion. These processes occurred at the time scale of membrane integration, synaptic plasticity and gamma oscillations. Finally, assembly–reader couplings were selectively modified upon associative learning, indicating that they were plastic and could become bound to behaviorally relevant variables. These results support cell assemblies as an endogenous mechanism for brain function." @default.
- W4295015124 created "2022-09-09" @default.
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- W4295015124 date "2022-09-07" @default.
- W4295015124 modified "2023-10-03" @default.
- W4295015124 title "Flexible communication between cell assemblies and ‘reader’ neurons" @default.
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- W4295015124 doi "https://doi.org/10.1101/2022.09.06.506754" @default.
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