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- W4295015175 abstract "CTP synthase (CTPS), a metabolic enzyme responsible for the de novo synthesis of CTP, can form filamentous structures termed cytoophidia, which are evolutionarily conserved from bacteria to humans. Here we used Schizosaccharomyces pombe to study the cytoophidium assembly regulation by ubiquitination. We tested the CTP synthase's capacity to be post-translationally modified by ubiquitin or be affected by the ubiquitination state of the cell and showed that ubiquitination is important for the maintenance of the CTPS filamentous structure in fission yeast. We have identified proteins which are in complex with CTPS, including specific ubiquitination regulators which significantly affect CTPS filamentation, and mapped probable ubiquitination targets on CTPS. Furthermore, we discovered that a cohort of deubiquitinating enzymes is important for the regulation of cytoophidium's filamentous morphology. Our study provides a framework for the analysis of the effects that ubiquitination and deubiquitination have on the formation of cytoophidia." @default.
- W4295015175 created "2022-09-09" @default.
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- W4295015175 date "2022-11-01" @default.
- W4295015175 modified "2023-10-17" @default.
- W4295015175 title "Ubiquitination regulates cytoophidium assembly in Schizosaccharomyces pombe" @default.
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- W4295015175 doi "https://doi.org/10.1016/j.yexcr.2022.113337" @default.
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