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• W4295024904 startingPage "523" @default.
• W4295024904 abstract "This chapter presents a synopsis of African medicinal plants and their derived products with antimycobacterial properties. Several secondary plant metabolites are reported to have anti-tuberculosis activity comparable to existing anti-tuberculosis drugs. Using the data obtained from 77 active plant extracts and 75 active derived molecules towards Mycobacterium tuberculosis H37Rv, the rationale cut-off points for the classification of antimycobacterial agents from natural sources were established. (i) For botanicals: outstanding activity when MIC ≤ 6 µg/mL; excellent activity when 6 < MIC ≤ 16 µg/mL; very good activity when 16 < MIC ≤ 25 µg/mL; good activity when 25 < MIC ≤ 39 µg/mL, average activity when 39 < MIC ≤ 156 µg/mL, weak activity when 156 < MIC ≤ 2048 µg/mL, and not active MIC> 2048 µg/mL. (ii) For phytochemicals: outstanding activity when MIC ≤ 2.5 µg/mL, excellent activity when 2.5 < MIC ≤ 5R01;µg/mL, very good activity when 5<MIC≤8 µg/mL, good activity when 8<MIC≤10 µg/mL, average activity when 10<MIC≤20 µg/mL, weak activity when 20<MIC≤512 µg/mL, and not active when MIC>512 µg/mL. Importantly, we have identified Artemisia abyssinica Schultz Bip. (Lamiaceae), Diospyros canaliculata De Wildeman (Ebenaceae), Diospyros crassiflora Hien (Ebenaceae), Croton macrostachyus Hochst. ex Del. (Lamiaceae), and Echinops giganteus A. Rich (Asteraceae) as the most active plants, and isobachalcone ( 1 ), diospyrone ( 2 ), laburnetin ( 3 ), 3,4′-di- O -methylellagic acid 3′- O-β- D - xylopyranoside ( 4 ), O 1 -demethyl-3′,4′-deoxy-psorospermi-3′,4′ diol ( 5 ), plumbagin ( 6 ), crassiflorone ( 7 ), and bafoudiosbulbins C ( 8 ), as the most promising antimycobacterial phytochemicals." @default.
• W4295024904 created "2022-09-09" @default.
• W4295024904 creator A5050551827 @default.
• W4295024904 creator A5057941412 @default.
• W4295024904 date "2023-01-01" @default.
• W4295024904 modified "2023-09-30" @default.
• W4295024904 title "Potential of African flora to combat tuberculosis and drug resistance of Mycobacteria: Rationale classification of antimycobacterial agents from a natural source" @default.
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