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- W4295024963 endingPage "149" @default.
- W4295024963 startingPage "81" @default.
- W4295024963 abstract "Plants hold great promise as a source of novel antimicrobial agents due to a wide variety of chemically and structurally diverse secondary metabolites generally grouped into terpenoids, phenolics and polyphenols, and alkaloids. Historical records and modern investigations highlight the importance of plant products in the treatment of bacterial diseases. Though there are a plethora of antibacterial compounds originating from plants, only a very small number of them have already been examined under clinical trials. Plants make up only a tiny percentage of the current repertoire of FDA-approved antibacterial drugs (contributing just 3%). Therefore, the current percentage of approved antibacterial drugs from plants does not accurately reflect the potential of plant natural products for future applications as antibacterial therapies. In part, there are some inherent difficulties in the development of plant natural products as antimicrobial pharmaceuticals including among others their incredibly chemically complex and rediscovery of the same compounds from different sources. This chapter provides an overview of the well-known plant-based antibacterial drugs/compounds. The historical role of plants in medicine, the major groups of plant secondary metabolites, the ethnobotanical and experimental approaches to antibacterial drug discovery, the antibacterial modes of action, and innovative targets for future drug discovery efforts are also proposed. Toxicity and safety implications of herbal medicines as well as some patents associated with phytochemicals and plant-based drugs for the treatment of bacterial infections are presented." @default.
- W4295024963 created "2022-09-09" @default.
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- W4295024963 date "2023-01-01" @default.
- W4295024963 modified "2023-09-29" @default.
- W4295024963 title "Established antibacterial drugs from plants" @default.
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