FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295030092> ?p ?o ?g. }

• W4295030092 endingPage "1572" @default.
• W4295030092 startingPage "1558" @default.
• W4295030092 abstract "Influenza A virus (IAV) infection poses a substantial challenge and causes high morbidity and mortality. Exacerbated pulmonary inflammatory responses are the major causes of extensive diffuse alveolar immunopathological damage. However, the relationship between the extent of cytokine storm, neutrophils/macrophages infiltration, and different IAV infection dose and time still needs to be further elucidated, and it is still unclear whether the signal transduction and transcriptional activator 1/3 (STAT1/3) signalling pathway plays a beneficial or detrimental role. Here, we established a mouse model of high- and low-dose pH1N1 infection. We found that pH1N1 infection induced robust and early pathological damage and cytokine storm in an infection dose- and time-dependent manner. High-dose pH1N1 infection induced massive and sustained recruitment of neutrophils as well as a higher ratio of M1:M2, which may contribute to severe lung immunopathological damage. pH1N1 infection activated dose- and time-dependent STAT1 and STAT3. Inhibition of STAT1 and/or STAT3 aggravated low-dose pH1N1 infection, induced lung damage, and decreased survival rate. Appropriate activation of STAT1/3 provided survival benefits and pathological improvement during low-dose pH1N1 infection. These results demonstrate that high-dose pH1N1 infection induces robust and sustained neutrophil infiltration, imbalanced macrophage polarization, excessive and earlier cytokine storm, and STAT1/3 activation, which are associated with pulmonary dysregulated proinflammatory responses and progress of acute lung injury. The severe innate immune responses may be the threshold at which protective functions give way to immunopathology, and assessing the magnitude of host innate immune responses is necessary in adjunctive immunomodulatory therapy for alleviating influenza-induced pneumonia." @default.
• W4295030092 created "2022-09-09" @default.
• W4295030092 creator A5025744336 @default.
• W4295030092 creator A5028437800 @default.
• W4295030092 creator A5040329116 @default.
• W4295030092 creator A5046597133 @default.
• W4295030092 creator A5073699504 @default.
• W4295030092 creator A5080931518 @default.
• W4295030092 creator A5082751166 @default.
• W4295030092 creator A5083510148 @default.
• W4295030092 creator A5090815103 @default.
• W4295030092 date "2022-09-09" @default.
• W4295030092 modified "2023-10-17" @default.
• W4295030092 title "H1N1 influenza virus dose dependent induction of dysregulated innate immune responses and STAT1/3 activation are associated with pulmonary immunopathological damage" @default.
• W4295030092 cites W1483334228 @default.
• W4295030092 cites W1503241441 @default.
• W4295030092 cites W1944615519 @default.
• W4295030092 cites W1975461687 @default.
• W4295030092 cites W1996311210 @default.
• W4295030092 cites W2015359732 @default.
• W4295030092 cites W2031997312 @default.
• W4295030092 cites W2033259268 @default.
• W4295030092 cites W2035509260 @default.
• W4295030092 cites W2036630090 @default.
• W4295030092 cites W2045123063 @default.
• W4295030092 cites W2054472394 @default.
• W4295030092 cites W2074390096 @default.
• W4295030092 cites W2081810806 @default.
• W4295030092 cites W2093913464 @default.
• W4295030092 cites W2103293702 @default.
• W4295030092 cites W2107551122 @default.
• W4295030092 cites W2123303185 @default.
• W4295030092 cites W2130014663 @default.
• W4295030092 cites W2133402546 @default.
• W4295030092 cites W2176189120 @default.
• W4295030092 cites W2232260051 @default.
• W4295030092 cites W2317848804 @default.
• W4295030092 cites W2528968729 @default.
• W4295030092 cites W2582620890 @default.
• W4295030092 cites W2742993647 @default.
• W4295030092 cites W2750766843 @default.
• W4295030092 cites W2767826331 @default.
• W4295030092 cites W2782685575 @default.
• W4295030092 cites W2801502233 @default.
• W4295030092 cites W2884747526 @default.
• W4295030092 cites W2900525400 @default.
• W4295030092 cites W2907471984 @default.
• W4295030092 cites W2907614968 @default.
• W4295030092 cites W2913496777 @default.
• W4295030092 cites W2964477617 @default.
• W4295030092 cites W2965379348 @default.
• W4295030092 cites W2965610345 @default.
• W4295030092 cites W2969423276 @default.
• W4295030092 cites W2982716340 @default.
• W4295030092 cites W3002371404 @default.
• W4295030092 cites W3014812514 @default.
• W4295030092 cites W3015079632 @default.
• W4295030092 cites W3020655115 @default.
• W4295030092 cites W3023982717 @default.
• W4295030092 cites W3043029189 @default.
• W4295030092 cites W3092538635 @default.
• W4295030092 cites W3098697637 @default.
• W4295030092 cites W3105908160 @default.
• W4295030092 cites W3112902030 @default.
• W4295030092 cites W3125396223 @default.
• W4295030092 cites W3138528543 @default.
• W4295030092 cites W3183857474 @default.
• W4295030092 cites W4214580553 @default.
• W4295030092 cites W4297738422 @default.
• W4295030092 cites W949564680 @default.
• W4295030092 doi "https://doi.org/10.1080/21505594.2022.2120951" @default.
• W4295030092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36082929" @default.
• W4295030092 hasPublicationYear "2022" @default.
• W4295030092 type Work @default.
• W4295030092 citedByCount "5" @default.
• W4295030092 countsByYear W42950300922022 @default.
• W4295030092 countsByYear W42950300922023 @default.
• W4295030092 crossrefType "journal-article" @default.
• W4295030092 hasAuthorship W4295030092A5025744336 @default.
• W4295030092 hasAuthorship W4295030092A5028437800 @default.
• W4295030092 hasAuthorship W4295030092A5040329116 @default.
• W4295030092 hasAuthorship W4295030092A5046597133 @default.
• W4295030092 hasAuthorship W4295030092A5073699504 @default.
• W4295030092 hasAuthorship W4295030092A5080931518 @default.
• W4295030092 hasAuthorship W4295030092A5082751166 @default.
• W4295030092 hasAuthorship W4295030092A5083510148 @default.
• W4295030092 hasAuthorship W4295030092A5090815103 @default.
• W4295030092 hasBestOaLocation W42950300921 @default.
• W4295030092 hasConcept C126322002 @default.
• W4295030092 hasConcept C136449434 @default.
• W4295030092 hasConcept C142724271 @default.
• W4295030092 hasConcept C164027704 @default.
• W4295030092 hasConcept C203014093 @default.
• W4295030092 hasConcept C2522874641 @default.
• W4295030092 hasConcept C2776178377 @default.
• W4295030092 hasConcept C2776914184 @default.
• W4295030092 hasConcept C2777003663 @default.
• W4295030092 hasConcept C2777546802 @default.

• next