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• W4295030440 abstract "Abstract Intraepithelial T lymphocytes (T-IELs) are T cells located within the epithelium that provide a critical line of immune defense in the intestinal tract. In pigs, T-IEL abundances and phenotypes are used to infer putative T-IEL functions and vary by intestinal location and age, though investigations regarding porcine T-IELs are relatively limited. In this study, we expand on analyses of porcine intestinal T-IELs to include additional phenotypic designations not previously recognized in pigs. We describe non-conventional CD8α + CD8β - αβ T-IELs that were most prevalent in the distal intestinal tract and primarily CD16 + CD27 - , a phenotype suggestive of innate-like activation and an activated cell state. Additional T-IEL populations included CD8α + CD8β + αβ, CD2 + CD8α + γδ, and CD2 + CD8α - γδ T-IELs, with increasing proportions of CD16 + CD27 - phenotype in the distal intestine. Thus, putative non-conventional, activated T-IELs were most abundant in the distal intestine within multiple γδ and αβ T-IEL populations. A comparison of T-IEL and respective mucosal microbial community structures across jejunum, ileum, and cecum of 5- and 7-week-old pigs revealed largest community differences were tissue-dependent for both T-IELs and the microbiota. Between 5 and 7 weeks of age, the largest shifts in microbial community compositions occurred in the large intestine, while the largest shifts in T-IEL communities were in the small intestine. Therefore, results indicate different rates of community maturation and stabilization for porcine T-IELs and the mucosal microbiota for proximal versus distal intestinal locations between 5 and 7 weeks of age. Collectively, data emphasize the intestinal tract as a site of location- and age-specific T-IEL and microbial communities that have important implications for understanding intestinal health in pigs." @default.
• W4295030440 created "2022-09-09" @default.
• W4295030440 creator A5003015899 @default.
• W4295030440 creator A5004054643 @default.
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• W4295030440 creator A5049049507 @default.
• W4295030440 date "2022-09-09" @default.
• W4295030440 modified "2023-09-26" @default.
• W4295030440 title "Intestinal location- and age-specific variation of intraepithelial T lymphocytes and mucosal microbiota in pigs" @default.
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• W4295030440 doi "https://doi.org/10.21203/rs.3.rs-2019467/v1" @default.
• W4295030440 hasPublicationYear "2022" @default.
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