Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295037927> ?p ?o ?g. }
- W4295037927 endingPage "14" @default.
- W4295037927 startingPage "1" @default.
- W4295037927 abstract "Globally, liver cancer (LC) is the sixth-most frequently occurring and the second-most fatal malignancy, responsible for 0.83 million deaths annually. Although the application of herbal drugs in cancer therapies has increased, their anti-LC activity and relevant mechanisms have not been fully studied from a systems perspective. To address these issues, we conducted a system-perspective network pharmacological investigation into the activity and mechanisms underlying the action of the herbal drug. FDY003 reduced the viability of human LC treatment. FDY003 reduced the viability of human LC cells and elevated their chemosensitivity. There were a total of 16 potential bioactive chemical components in FDY003 and they had 91 corresponding targets responsible for the pathological processes in LC. These FDY003 targets were functionally involved in regulating the survival, proliferation, apoptosis, and cell cycle of LC cells. Additionally, we found that FDY003 may target key signaling cascades connected to diverse LC pathological mechanisms, namely, PI3K-Akt, focal adhesion, IL-17, FoxO, MAPK, and TNF pathways. Overall, this study contributed to integrative mechanistic insights into the anti-LC potential of FDY003." @default.
- W4295037927 created "2022-09-09" @default.
- W4295037927 creator A5007167421 @default.
- W4295037927 creator A5043864341 @default.
- W4295037927 creator A5049467312 @default.
- W4295037927 creator A5050246644 @default.
- W4295037927 creator A5064912744 @default.
- W4295037927 creator A5077084628 @default.
- W4295037927 creator A5080719670 @default.
- W4295037927 date "2022-09-09" @default.
- W4295037927 modified "2023-10-14" @default.
- W4295037927 title "Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology" @default.
- W4295037927 cites W1500176915 @default.
- W4295037927 cites W1516697345 @default.
- W4295037927 cites W1544009106 @default.
- W4295037927 cites W1554390018 @default.
- W4295037927 cites W1567333450 @default.
- W4295037927 cites W166409149 @default.
- W4295037927 cites W1803954903 @default.
- W4295037927 cites W1809990660 @default.
- W4295037927 cites W1931826177 @default.
- W4295037927 cites W1957760917 @default.
- W4295037927 cites W1965397916 @default.
- W4295037927 cites W1969065905 @default.
- W4295037927 cites W1973798273 @default.
- W4295037927 cites W1974944535 @default.
- W4295037927 cites W1981394734 @default.
- W4295037927 cites W1985569200 @default.
- W4295037927 cites W1990236573 @default.
- W4295037927 cites W2008791994 @default.
- W4295037927 cites W2009897233 @default.
- W4295037927 cites W2015816582 @default.
- W4295037927 cites W2024985940 @default.
- W4295037927 cites W2025999723 @default.
- W4295037927 cites W2033608521 @default.
- W4295037927 cites W2038464222 @default.
- W4295037927 cites W2042753075 @default.
- W4295037927 cites W2047689303 @default.
- W4295037927 cites W2056776207 @default.
- W4295037927 cites W2057067795 @default.
- W4295037927 cites W2059130287 @default.
- W4295037927 cites W2060761908 @default.
- W4295037927 cites W2063280109 @default.
- W4295037927 cites W2069676201 @default.
- W4295037927 cites W2085002868 @default.
- W4295037927 cites W2091675295 @default.
- W4295037927 cites W2093652723 @default.
- W4295037927 cites W2099887488 @default.
- W4295037927 cites W2111070218 @default.
- W4295037927 cites W2118258530 @default.
- W4295037927 cites W2119572010 @default.
- W4295037927 cites W2122725894 @default.
- W4295037927 cites W2124679671 @default.
- W4295037927 cites W2127401224 @default.
- W4295037927 cites W2130790725 @default.
- W4295037927 cites W2133610472 @default.
- W4295037927 cites W2133776184 @default.
- W4295037927 cites W2134178487 @default.
- W4295037927 cites W2134967712 @default.
- W4295037927 cites W2138902556 @default.
- W4295037927 cites W2141713243 @default.
- W4295037927 cites W2146980885 @default.
- W4295037927 cites W2155528918 @default.
- W4295037927 cites W2157781641 @default.
- W4295037927 cites W2158217645 @default.
- W4295037927 cites W2158485828 @default.
- W4295037927 cites W2159675211 @default.
- W4295037927 cites W2162011385 @default.
- W4295037927 cites W2162151166 @default.
- W4295037927 cites W2163480486 @default.
- W4295037927 cites W2163532069 @default.
- W4295037927 cites W2166223086 @default.
- W4295037927 cites W2179175379 @default.
- W4295037927 cites W2181455799 @default.
- W4295037927 cites W2210526074 @default.
- W4295037927 cites W2279201083 @default.
- W4295037927 cites W2294516783 @default.
- W4295037927 cites W2295786120 @default.
- W4295037927 cites W2300842584 @default.
- W4295037927 cites W2301448326 @default.
- W4295037927 cites W2339955006 @default.
- W4295037927 cites W2339977836 @default.
- W4295037927 cites W2388357290 @default.
- W4295037927 cites W2406255426 @default.
- W4295037927 cites W2409099281 @default.
- W4295037927 cites W2409483347 @default.
- W4295037927 cites W2442673105 @default.
- W4295037927 cites W2442910829 @default.
- W4295037927 cites W2477004497 @default.
- W4295037927 cites W2534088339 @default.
- W4295037927 cites W2537679995 @default.
- W4295037927 cites W2555080840 @default.
- W4295037927 cites W2557924600 @default.
- W4295037927 cites W2559588208 @default.
- W4295037927 cites W2567357425 @default.
- W4295037927 cites W2573178309 @default.
- W4295037927 cites W2579312283 @default.
- W4295037927 cites W2582372140 @default.