FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295047876> ?p ?o ?g. }

• W4295047876 endingPage "501" @default.
• W4295047876 startingPage "497" @default.
• W4295047876 abstract "Smoking contributes to significant morbidity and mortality in people with HIV. People with HIV have relatively high nicotine metabolism rates, as measured by the nicotine metabolite ratio (NMR, 3-hydroxycotinine/cotinine). A higher NMR is associated with difficulty quitting smoking. We hypothesized that HIV infection might upregulate nicotine metabolism.A retrospective study of male current smokers in the Multicenter AIDS Cohort Study who HIV seroconverted between 1985 and 1993.Eligibility included having plasma stored before and after confirmed HIV seroconversion and current tobacco use. Samples were selected from the closest available visits before (median 3.3 months) and after (median 9.4 months) seroconversion. Antiretroviral therapy use was exclusionary. Cotinine and 3-hydroxycotinine were measured using liquid chromatography-tandem mass spectrometry. We compared NMR from plasma pre-HIV and post-HIV infection using signed-rank tests. We targeted a sample size of 71 pairs to achieve 80% power to detect a 0.1 unit increase in NMR with P = 0.05.We analyzed paired samples from 78 participants; the median age was 34.5 years [interquartile range (IQR 29-40 years)]. The median NMR pre-HIV and post-HIV was 0.45 (IQR 0.32-0.54) and 0.46 (IQR 0.34-0.56), respectively. The median change in NMR postseroconversion was +0.01 (IQR -0.05, +0.09), P = 0.25. Stratification of median change in NMR by timing between samples or time since HIV seroconversion did not alter this finding.Acquiring HIV had no measurable effect on NMR. We postulate that upregulation of the NMR may be due to direct pharmacologic effects of HIV medications or metabolic changes in response to HIV infection." @default.
• W4295047876 created "2022-09-09" @default.
• W4295047876 creator A5001818262 @default.
• W4295047876 creator A5009166326 @default.
• W4295047876 creator A5011913674 @default.
• W4295047876 creator A5015107487 @default.
• W4295047876 creator A5020267243 @default.
• W4295047876 creator A5024575747 @default.
• W4295047876 creator A5043174070 @default.
• W4295047876 creator A5057100062 @default.
• W4295047876 creator A5065472330 @default.
• W4295047876 creator A5082109429 @default.
• W4295047876 creator A5084013548 @default.
• W4295047876 creator A5089045105 @default.
• W4295047876 creator A5089957599 @default.
• W4295047876 date "2022-12-15" @default.
• W4295047876 modified "2023-10-18" @default.
• W4295047876 title "Brief Report: HIV Infection Does Not Explain Higher Nicotine Metabolism in People Living With HIV" @default.
• W4295047876 cites W1955514624 @default.
• W4295047876 cites W1981301633 @default.
• W4295047876 cites W1985454368 @default.
• W4295047876 cites W1991137866 @default.
• W4295047876 cites W1993551104 @default.
• W4295047876 cites W2012763305 @default.
• W4295047876 cites W2015234747 @default.
• W4295047876 cites W2025660290 @default.
• W4295047876 cites W2030471578 @default.
• W4295047876 cites W2045750390 @default.
• W4295047876 cites W2091173057 @default.
• W4295047876 cites W2102073909 @default.
• W4295047876 cites W2107897538 @default.
• W4295047876 cites W2112795984 @default.
• W4295047876 cites W2114694355 @default.
• W4295047876 cites W2124496403 @default.
• W4295047876 cites W2152939975 @default.
• W4295047876 cites W2170328207 @default.
• W4295047876 cites W2170821252 @default.
• W4295047876 cites W2309907686 @default.
• W4295047876 cites W2604898263 @default.
• W4295047876 cites W2613065743 @default.
• W4295047876 cites W2613716993 @default.
• W4295047876 cites W2791074071 @default.
• W4295047876 cites W2886105060 @default.
• W4295047876 cites W2909949780 @default.
• W4295047876 cites W2962908310 @default.
• W4295047876 cites W3010253170 @default.
• W4295047876 cites W3017687726 @default.
• W4295047876 cites W3037579907 @default.
• W4295047876 cites W3093473682 @default.
• W4295047876 cites W3105560370 @default.
• W4295047876 cites W3106028942 @default.
• W4295047876 cites W3176090025 @default.
• W4295047876 cites W4200089937 @default.
• W4295047876 doi "https://doi.org/10.1097/qai.0000000000003089" @default.
• W4295047876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36083509" @default.
• W4295047876 hasPublicationYear "2022" @default.
• W4295047876 type Work @default.
• W4295047876 citedByCount "0" @default.
• W4295047876 crossrefType "journal-article" @default.
• W4295047876 hasAuthorship W4295047876A5001818262 @default.
• W4295047876 hasAuthorship W4295047876A5009166326 @default.
• W4295047876 hasAuthorship W4295047876A5011913674 @default.
• W4295047876 hasAuthorship W4295047876A5015107487 @default.
• W4295047876 hasAuthorship W4295047876A5020267243 @default.
• W4295047876 hasAuthorship W4295047876A5024575747 @default.
• W4295047876 hasAuthorship W4295047876A5043174070 @default.
• W4295047876 hasAuthorship W4295047876A5057100062 @default.
• W4295047876 hasAuthorship W4295047876A5065472330 @default.
• W4295047876 hasAuthorship W4295047876A5082109429 @default.
• W4295047876 hasAuthorship W4295047876A5084013548 @default.
• W4295047876 hasAuthorship W4295047876A5089045105 @default.
• W4295047876 hasAuthorship W4295047876A5089957599 @default.
• W4295047876 hasConcept C119060515 @default.
• W4295047876 hasConcept C126322002 @default.
• W4295047876 hasConcept C203014093 @default.
• W4295047876 hasConcept C2776319443 @default.
• W4295047876 hasConcept C2777451964 @default.
• W4295047876 hasConcept C2777477808 @default.
• W4295047876 hasConcept C2779547902 @default.
• W4295047876 hasConcept C3013748606 @default.
• W4295047876 hasConcept C71924100 @default.
• W4295047876 hasConcept C72563966 @default.
• W4295047876 hasConceptScore W4295047876C119060515 @default.
• W4295047876 hasConceptScore W4295047876C126322002 @default.
• W4295047876 hasConceptScore W4295047876C203014093 @default.
• W4295047876 hasConceptScore W4295047876C2776319443 @default.
• W4295047876 hasConceptScore W4295047876C2777451964 @default.
• W4295047876 hasConceptScore W4295047876C2777477808 @default.
• W4295047876 hasConceptScore W4295047876C2779547902 @default.
• W4295047876 hasConceptScore W4295047876C3013748606 @default.
• W4295047876 hasConceptScore W4295047876C71924100 @default.
• W4295047876 hasConceptScore W4295047876C72563966 @default.
• W4295047876 hasIssue "5" @default.
• W4295047876 hasLocation W42950478761 @default.
• W4295047876 hasLocation W42950478762 @default.
• W4295047876 hasOpenAccess W4295047876 @default.
• W4295047876 hasPrimaryLocation W42950478761 @default.
• W4295047876 hasRelatedWork W151590255 @default.

• next