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• W4295048803 abstract "Abstract The intracranial pressure is implicated in many homeostatic processes in the brain and is a fundamental parameter in several diseases such as e.g. idiopathic normal pressure hydrocephalus (iNPH). The presence of a small but persistent pulsatile intracranial pulsatile transmantle pressure gradient (on the order of a few mmHg/m at peak) has recently been demonstrated in iNPH subjects. A key question is whether pulsatile ICP and displacements can be induced by a small pressure gradient originating from the brain surface e.g. pial arteries alone. In this study, we model the brain parenchyma as either a linearly elastic or a poroelastic medium and impose a pulsatile pressure gradient acting between the ventricular and the pial surfaces. Using this high-resolution physics-based model, we compute the effect of the pulsatile pressure gradient on parenchyma displacement, volume change, fluid pressure, and fluid flux. The resulting displacement field is pulsatile and in qualitatively and quantitatively good agreement with the literature, both with elastic and poroelastic models. However, the pulsatile forces on the boundaries are not sufficient for pressure pulse propagation through the brain parenchyma. Our results suggest that pressure differences originating over the brain surface via e.g. pial artery pulsatility are not sufficient to drive interstitial fluid (ISF) flow within the brain parenchyma and that potential pressure gradients found within the parenchyma rather arise from local pressure pulsations of blood vessels within the brain parenchyma itself." @default.
• W4295048803 created "2022-09-09" @default.
• W4295048803 creator A5006835667 @default.
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• W4295048803 date "2022-09-09" @default.
• W4295048803 modified "2023-09-27" @default.
• W4295048803 title "Are brain displacements and pressures within the parenchyma induced by surface pressure differences? A computational modelling study" @default.
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• W4295048803 doi "https://doi.org/10.1101/2022.09.07.506967" @default.
• W4295048803 hasPublicationYear "2022" @default.
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