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• W4295073670 abstract "Regulation of gene expression is linked to the organization of the genome. With age, chromatin alterations occur on all levels of genome organization, accompanied by changes in the gene expression profile. However, little is known about the changes in the level of transcriptional regulation. Here, we used a multi-omics approach and integrated ATAC-, RNA- and NET-seq to identify age-related changes in the chromatin landscape of murine liver and to investigate how these are linked to transcriptional regulation. We provide the first systematic inventory of the connection between aging, chromatin accessibility, and transcriptional regulation in a whole tissue. Aging in murine liver is characterized by an increase in chromatin accessibility at promoter regions, but not in an increase in transcriptional output. Instead, aging is accompanied by a decrease in promoter-proximal pausing of RNA polymerase II (Pol II), while initiation of transcription is not decreased as assessed by RNA polymerase mapping using CUT&RUN. Based on the data reported, we propose that these age-related changes in transcriptional regulation are due to a reduced stability of the pausing complex." @default.
• W4295073670 created "2022-09-10" @default.
• W4295073670 creator A5034262236 @default.
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• W4295073670 creator A5055442595 @default.
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• W4295073670 date "2022-09-01" @default.
• W4295073670 modified "2023-10-14" @default.
• W4295073670 title "Aging is associated with increased chromatin accessibility and reduced polymerase pausing in liver" @default.
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• W4295073670 doi "https://doi.org/10.15252/msb.202211002" @default.
• W4295073670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36082605" @default.
• W4295073670 hasPublicationYear "2022" @default.
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