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- W4295078732 abstract "The potential for a donor-derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation. This review gives a short description of the viral properties and summarizes the current evidence of the effects of PCMV/PRV transmission in preclinical xenotransplantation. Despite evidence that PCMV/PRV does not infect human and non-human primate cells, activation in the transplanted organ and detrimental systemic complications have been described. As PCMV/PRV is a herpesvirus able to establish latency, the importance of adequate screening of donor pigs is emphasized, as no efficient treatment is available. Furthermore, easy and successful ways of elimination of PCMV/PRV from pig herds are indicated." @default.
- W4295078732 created "2022-09-10" @default.
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- W4295078732 date "2022-09-01" @default.
- W4295078732 modified "2023-09-25" @default.
- W4295078732 title "Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?" @default.
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- W4295078732 doi "https://doi.org/10.1111/xen.12775" @default.
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