Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295079512> ?p ?o ?g. }
- W4295079512 endingPage "3633" @default.
- W4295079512 startingPage "3633" @default.
- W4295079512 abstract "The aim of the study was to explain the effects of sesquiterpene lactones (SLs) from chicory (Cichorium intybus L.) root extracts as inhibitors of acetylcholinesterase (AChE) at the molecular level and to determine the inhibition of AChE activity by specific SLs (lactucin and lactucopicrin) and different chicory extracts. The obtained SLs-rich extracts were purified by the countercurrent partition chromatography (CPC) technique. AChE inhibitors were analyzed using two models: isothermal titration calorimetry (ITC) and docking simulation. The results of ITC analysis of the enzyme and the ligands' complexation showed strong interactions of SLs as well as extracts from chicory with AChE. In a test of enzyme activity inhibition after introducing acetylcholine into the model system with SL, a stronger ability to inhibit the hydrolysis of the neurotransmitter was observed for lactucopicrin, which is one of the dominant SLs in chicory. The inhibition of enzyme activity was more efficient in the case of extracts, containing different enzyme ligands, exhibiting complementary patterns of binding the AChE active site. The study showed the high potential of using chicory to decrease the symptoms of Alzheimer's disease." @default.
- W4295079512 created "2022-09-10" @default.
- W4295079512 creator A5009581595 @default.
- W4295079512 creator A5037673215 @default.
- W4295079512 creator A5038136748 @default.
- W4295079512 creator A5055539831 @default.
- W4295079512 date "2022-09-02" @default.
- W4295079512 modified "2023-10-14" @default.
- W4295079512 title "Evaluation of Activity of Sesquiterpene Lactones and Chicory Extracts as Acetylcholinesterase Inhibitors Assayed in Calorimetric and Docking Simulation Studies" @default.
- W4295079512 cites W1876466307 @default.
- W4295079512 cites W1977666346 @default.
- W4295079512 cites W1985884820 @default.
- W4295079512 cites W1993752937 @default.
- W4295079512 cites W2010547035 @default.
- W4295079512 cites W2013760445 @default.
- W4295079512 cites W2027423337 @default.
- W4295079512 cites W2031168104 @default.
- W4295079512 cites W2047441116 @default.
- W4295079512 cites W2048223876 @default.
- W4295079512 cites W2054657917 @default.
- W4295079512 cites W2056762691 @default.
- W4295079512 cites W2067171548 @default.
- W4295079512 cites W2090840222 @default.
- W4295079512 cites W2134832655 @default.
- W4295079512 cites W2151256267 @default.
- W4295079512 cites W2186722742 @default.
- W4295079512 cites W2255246778 @default.
- W4295079512 cites W2463778486 @default.
- W4295079512 cites W2561776958 @default.
- W4295079512 cites W2566720622 @default.
- W4295079512 cites W2570190684 @default.
- W4295079512 cites W2801828951 @default.
- W4295079512 cites W2805448762 @default.
- W4295079512 cites W2808059703 @default.
- W4295079512 cites W2893930979 @default.
- W4295079512 cites W2903730833 @default.
- W4295079512 cites W2912818999 @default.
- W4295079512 cites W2982956982 @default.
- W4295079512 cites W2998928322 @default.
- W4295079512 cites W3009728834 @default.
- W4295079512 cites W3012895911 @default.
- W4295079512 cites W3046160003 @default.
- W4295079512 cites W3086540077 @default.
- W4295079512 cites W3092032238 @default.
- W4295079512 cites W3103725446 @default.
- W4295079512 cites W3107927965 @default.
- W4295079512 cites W3133291488 @default.
- W4295079512 cites W3150910406 @default.
- W4295079512 cites W3174482405 @default.
- W4295079512 cites W4214853348 @default.
- W4295079512 doi "https://doi.org/10.3390/nu14173633" @default.
- W4295079512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36079888" @default.
- W4295079512 hasPublicationYear "2022" @default.
- W4295079512 type Work @default.
- W4295079512 citedByCount "2" @default.
- W4295079512 countsByYear W42950795122023 @default.
- W4295079512 crossrefType "journal-article" @default.
- W4295079512 hasAuthorship W4295079512A5009581595 @default.
- W4295079512 hasAuthorship W4295079512A5037673215 @default.
- W4295079512 hasAuthorship W4295079512A5038136748 @default.
- W4295079512 hasAuthorship W4295079512A5055539831 @default.
- W4295079512 hasBestOaLocation W42950795121 @default.
- W4295079512 hasConcept C156911925 @default.
- W4295079512 hasConcept C159110408 @default.
- W4295079512 hasConcept C181199279 @default.
- W4295079512 hasConcept C185592680 @default.
- W4295079512 hasConcept C2778011807 @default.
- W4295079512 hasConcept C2778816929 @default.
- W4295079512 hasConcept C2779059548 @default.
- W4295079512 hasConcept C28212737 @default.
- W4295079512 hasConcept C41685203 @default.
- W4295079512 hasConcept C43617362 @default.
- W4295079512 hasConcept C55493867 @default.
- W4295079512 hasConcept C59822182 @default.
- W4295079512 hasConcept C71924100 @default.
- W4295079512 hasConcept C86803240 @default.
- W4295079512 hasConceptScore W4295079512C156911925 @default.
- W4295079512 hasConceptScore W4295079512C159110408 @default.
- W4295079512 hasConceptScore W4295079512C181199279 @default.
- W4295079512 hasConceptScore W4295079512C185592680 @default.
- W4295079512 hasConceptScore W4295079512C2778011807 @default.
- W4295079512 hasConceptScore W4295079512C2778816929 @default.
- W4295079512 hasConceptScore W4295079512C2779059548 @default.
- W4295079512 hasConceptScore W4295079512C28212737 @default.
- W4295079512 hasConceptScore W4295079512C41685203 @default.
- W4295079512 hasConceptScore W4295079512C43617362 @default.
- W4295079512 hasConceptScore W4295079512C55493867 @default.
- W4295079512 hasConceptScore W4295079512C59822182 @default.
- W4295079512 hasConceptScore W4295079512C71924100 @default.
- W4295079512 hasConceptScore W4295079512C86803240 @default.
- W4295079512 hasIssue "17" @default.
- W4295079512 hasLocation W42950795121 @default.
- W4295079512 hasLocation W42950795122 @default.
- W4295079512 hasLocation W42950795123 @default.
- W4295079512 hasLocation W42950795124 @default.
- W4295079512 hasOpenAccess W4295079512 @default.
- W4295079512 hasPrimaryLocation W42950795121 @default.
- W4295079512 hasRelatedWork W2044216640 @default.