Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295087018> ?p ?o ?g. }
- W4295087018 endingPage "4318" @default.
- W4295087018 startingPage "4318" @default.
- W4295087018 abstract "CD8+ T cells and natural killer (NK) cells eliminate target cells through the release of lytic granules and Fas ligand (FasL)-induced target cell apoptosis. The introduction of chimeric antigen receptor (CAR) makes these two types of cells selective and effective in killing cancer cells. The success of CAR-T therapy in the treatment of acute lymphoblastic leukemia (ALL) and other types of blood cancers proved that the immunotherapy is an effective approach in fighting against cancers, yet adverse effects, such as graft versus host disease (GvHD) and cytokine release syndrome (CRS), cannot be ignored for the CAR-T therapy. CAR-NK therapy, then, has its advantage in lacking these adverse effects and works as effective as CAR-T in terms of killing. Despite these, NK cells are known to be hard to transduce, expand in vitro, and sustain shorter in vivo comparing to infiltrated T cells. Moreover, CAR-NK therapy faces challenges as CAR-T therapy does, e.g., the time, the cost, and the potential biohazard due to the use of animal-derived products. Thus, enormous efforts are needed to develop safe, effective, and large-scalable protocols for obtaining CAR-NK cells. Here, we reviewed current progress of CAR-NK therapy, including its biological properties, CAR compositions, preparation of CAR-NK cells, and clinical progresses. We also discussed safety issues raised from genetic engineering. We hope this review is instructive to the research community and a broad range of readers." @default.
- W4295087018 created "2022-09-10" @default.
- W4295087018 creator A5031645143 @default.
- W4295087018 creator A5038951834 @default.
- W4295087018 creator A5053044511 @default.
- W4295087018 creator A5068157211 @default.
- W4295087018 creator A5069855232 @default.
- W4295087018 date "2022-09-02" @default.
- W4295087018 modified "2023-10-18" @default.
- W4295087018 title "Current Progress of CAR-NK Therapy in Cancer Treatment" @default.
- W4295087018 cites W1274344746 @default.
- W4295087018 cites W1541594543 @default.
- W4295087018 cites W1607012924 @default.
- W4295087018 cites W1842126375 @default.
- W4295087018 cites W1939360714 @default.
- W4295087018 cites W1965397995 @default.
- W4295087018 cites W1967455230 @default.
- W4295087018 cites W1968369411 @default.
- W4295087018 cites W1969814796 @default.
- W4295087018 cites W1969950463 @default.
- W4295087018 cites W1970291858 @default.
- W4295087018 cites W1983143892 @default.
- W4295087018 cites W1991271747 @default.
- W4295087018 cites W1992347525 @default.
- W4295087018 cites W1997656140 @default.
- W4295087018 cites W1999695435 @default.
- W4295087018 cites W2001294380 @default.
- W4295087018 cites W2008919922 @default.
- W4295087018 cites W2010353459 @default.
- W4295087018 cites W2016523043 @default.
- W4295087018 cites W2024981673 @default.
- W4295087018 cites W2026148078 @default.
- W4295087018 cites W2029229136 @default.
- W4295087018 cites W2030677933 @default.
- W4295087018 cites W2032125984 @default.
- W4295087018 cites W2041235830 @default.
- W4295087018 cites W2045475405 @default.
- W4295087018 cites W2047205338 @default.
- W4295087018 cites W2047748738 @default.
- W4295087018 cites W2047942087 @default.
- W4295087018 cites W2057745345 @default.
- W4295087018 cites W2061899375 @default.
- W4295087018 cites W2062368814 @default.
- W4295087018 cites W2062504594 @default.
- W4295087018 cites W2081047303 @default.
- W4295087018 cites W2081788499 @default.
- W4295087018 cites W2091675007 @default.
- W4295087018 cites W2092166052 @default.
- W4295087018 cites W2093762704 @default.
- W4295087018 cites W2094945699 @default.
- W4295087018 cites W2096015304 @default.
- W4295087018 cites W2104581911 @default.
- W4295087018 cites W2105557870 @default.
- W4295087018 cites W2110820382 @default.
- W4295087018 cites W2119497696 @default.
- W4295087018 cites W2129278872 @default.
- W4295087018 cites W2130011407 @default.
- W4295087018 cites W2137108740 @default.
- W4295087018 cites W2144429525 @default.
- W4295087018 cites W2168328626 @default.
- W4295087018 cites W2170513194 @default.
- W4295087018 cites W2170981225 @default.
- W4295087018 cites W2171394431 @default.
- W4295087018 cites W2265134611 @default.
- W4295087018 cites W2268102483 @default.
- W4295087018 cites W2272769504 @default.
- W4295087018 cites W2339327563 @default.
- W4295087018 cites W2342423058 @default.
- W4295087018 cites W2398298261 @default.
- W4295087018 cites W2415443593 @default.
- W4295087018 cites W2475147046 @default.
- W4295087018 cites W2515130157 @default.
- W4295087018 cites W2569050105 @default.
- W4295087018 cites W2590004183 @default.
- W4295087018 cites W2598495496 @default.
- W4295087018 cites W2603369913 @default.
- W4295087018 cites W2605482562 @default.
- W4295087018 cites W2611896377 @default.
- W4295087018 cites W2612641392 @default.
- W4295087018 cites W2613180696 @default.
- W4295087018 cites W2615682320 @default.
- W4295087018 cites W2753630019 @default.
- W4295087018 cites W2761586559 @default.
- W4295087018 cites W2765434473 @default.
- W4295087018 cites W2770028022 @default.
- W4295087018 cites W2783731426 @default.
- W4295087018 cites W2787301955 @default.
- W4295087018 cites W2787621143 @default.
- W4295087018 cites W2789026035 @default.
- W4295087018 cites W2793886138 @default.
- W4295087018 cites W2795441690 @default.
- W4295087018 cites W2800595080 @default.
- W4295087018 cites W2804073610 @default.
- W4295087018 cites W2810715813 @default.
- W4295087018 cites W2887418427 @default.
- W4295087018 cites W2888019042 @default.
- W4295087018 cites W2890499629 @default.
- W4295087018 cites W2896902798 @default.