Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295088077> ?p ?o ?g. }
- W4295088077 endingPage "154" @default.
- W4295088077 startingPage "136" @default.
- W4295088077 abstract "Abstract Aim Myocardial infarction remains the leading cause of heart failure. The adult human heart lacks the capacity to undergo endogenous regeneration. New blood vessel growth is integral to regenerative medicine necessitating a comprehensive understanding of the pathways that regulate vascular regeneration. We sought to define the transcriptomic dynamics of coronary endothelial cells following ischaemic injuries in the developing and adult mouse and human heart and to identify new mechanistic insights and targets for cardiovascular regeneration. Methods and results We carried out a comprehensive meta-analysis of integrated single-cell RNA-sequencing data of coronary vascular endothelial cells from the developing and adult mouse and human heart spanning healthy and acute and chronic ischaemic cardiac disease. We identified species-conserved gene regulatory pathways aligned to endogenous neovascularization. We annotated injury-associated temporal shifts of the endothelial transcriptome and validated four genes: VEGF-C, KLF4, EGR1, and ZFP36. Moreover, we showed that ZFP36 regulates human coronary endothelial cell proliferation and defined that VEGF-C administration in vivo enhances clonal expansion of the cardiac vasculature post-myocardial infarction. Finally, we constructed a coronary endothelial cell meta-atlas, CrescENDO, to empower future in-depth research to target pathways associated with coronary neovascularization. Conclusion We present a high-resolution single-cell meta-atlas of healthy and injured coronary endothelial cells in the mouse and human heart, revealing a suite of novel targets with great potential to promote vascular regeneration, and providing a rich resource for therapeutic development." @default.
- W4295088077 created "2022-09-10" @default.
- W4295088077 creator A5000842073 @default.
- W4295088077 creator A5001787222 @default.
- W4295088077 creator A5025485683 @default.
- W4295088077 creator A5029617767 @default.
- W4295088077 creator A5036916652 @default.
- W4295088077 creator A5037137972 @default.
- W4295088077 creator A5044208632 @default.
- W4295088077 creator A5047012447 @default.
- W4295088077 creator A5057731130 @default.
- W4295088077 creator A5067717934 @default.
- W4295088077 creator A5070604114 @default.
- W4295088077 creator A5079360770 @default.
- W4295088077 creator A5082758671 @default.
- W4295088077 creator A5086937841 @default.
- W4295088077 date "2022-09-09" @default.
- W4295088077 modified "2023-10-03" @default.
- W4295088077 title "Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart" @default.
- W4295088077 cites W1568237782 @default.
- W4295088077 cites W1578501129 @default.
- W4295088077 cites W1669479280 @default.
- W4295088077 cites W1920486801 @default.
- W4295088077 cites W1963647601 @default.
- W4295088077 cites W1969038150 @default.
- W4295088077 cites W1978041309 @default.
- W4295088077 cites W1979423827 @default.
- W4295088077 cites W2013692456 @default.
- W4295088077 cites W2017288550 @default.
- W4295088077 cites W2028017696 @default.
- W4295088077 cites W2057697484 @default.
- W4295088077 cites W2063259131 @default.
- W4295088077 cites W2070114011 @default.
- W4295088077 cites W2078720314 @default.
- W4295088077 cites W2093842837 @default.
- W4295088077 cites W2095478806 @default.
- W4295088077 cites W2101986300 @default.
- W4295088077 cites W2102717891 @default.
- W4295088077 cites W2108373798 @default.
- W4295088077 cites W2116006032 @default.
- W4295088077 cites W2116041602 @default.
- W4295088077 cites W2118258530 @default.
- W4295088077 cites W2120024428 @default.
- W4295088077 cites W2120521583 @default.
- W4295088077 cites W2132388665 @default.
- W4295088077 cites W2137571589 @default.
- W4295088077 cites W2138584373 @default.
- W4295088077 cites W2144328385 @default.
- W4295088077 cites W2152279145 @default.
- W4295088077 cites W2153808458 @default.
- W4295088077 cites W2166098459 @default.
- W4295088077 cites W2170874249 @default.
- W4295088077 cites W2175209522 @default.
- W4295088077 cites W2180760460 @default.
- W4295088077 cites W2191859395 @default.
- W4295088077 cites W2286142055 @default.
- W4295088077 cites W2381396714 @default.
- W4295088077 cites W2588681363 @default.
- W4295088077 cites W2616922646 @default.
- W4295088077 cites W2671227891 @default.
- W4295088077 cites W2768631628 @default.
- W4295088077 cites W2769783454 @default.
- W4295088077 cites W2782933193 @default.
- W4295088077 cites W2794480084 @default.
- W4295088077 cites W2796544636 @default.
- W4295088077 cites W2809000676 @default.
- W4295088077 cites W2884217607 @default.
- W4295088077 cites W2888143563 @default.
- W4295088077 cites W2892550000 @default.
- W4295088077 cites W2898321887 @default.
- W4295088077 cites W2911685613 @default.
- W4295088077 cites W2912654919 @default.
- W4295088077 cites W2924188812 @default.
- W4295088077 cites W2948414306 @default.
- W4295088077 cites W2952100718 @default.
- W4295088077 cites W2969948459 @default.
- W4295088077 cites W2973370607 @default.
- W4295088077 cites W2979684492 @default.
- W4295088077 cites W2997280954 @default.
- W4295088077 cites W2999577865 @default.
- W4295088077 cites W3013151148 @default.
- W4295088077 cites W3038072510 @default.
- W4295088077 cites W3125573011 @default.
- W4295088077 cites W3130297181 @default.
- W4295088077 cites W3163648675 @default.
- W4295088077 cites W3211861956 @default.
- W4295088077 doi "https://doi.org/10.1093/cvr/cvac151" @default.
- W4295088077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36082978" @default.
- W4295088077 hasPublicationYear "2022" @default.
- W4295088077 type Work @default.
- W4295088077 citedByCount "4" @default.
- W4295088077 countsByYear W42950880772023 @default.
- W4295088077 crossrefType "journal-article" @default.
- W4295088077 hasAuthorship W4295088077A5000842073 @default.
- W4295088077 hasAuthorship W4295088077A5001787222 @default.
- W4295088077 hasAuthorship W4295088077A5025485683 @default.
- W4295088077 hasAuthorship W4295088077A5029617767 @default.
- W4295088077 hasAuthorship W4295088077A5036916652 @default.