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• W4295095871 abstract "first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Font Size: Aa Aa Aa Line Spacing:    Column Width:    Background: Open AccessAbstract A Microsystem for the Study of Vascularization † by Joanna Konopka 1,*, Patrycja Staniszewska 1, Agnieszka Żuchowska 1 and Elżbieta Jastrzębska 1,2,* 1 Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, 00-664 Warsaw, Poland 2 Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, 02-822 Warsaw, Poland * Authors to whom correspondence should be addressed. † Presented at the 9th International Symposium on Sensor Science, Warsaw, Poland, 20–22 June 2022. Eng. Proc. 2022, 21(1), 50; https://doi.org/10.3390/engproc2022021050 Published: 6 September 2022 (This article belongs to the Proceedings of The 9th International Symposium on Sensor Science) Download Download PDF Download XML Download Epub Versions Notes Angiogenesis is the development of new blood vessels from the already existing vasculature [1]. Its course is controlled by many pro- and anti-angiogenic factors. Disorders of the distribution of these agents lead to the development of cancer and cardiovascular diseases qualified by the World Health Organization as the leading causes of death globally. Understanding the mechanisms regulating physiological and pathological angiogenesis will allow for more effective treatment. The simulation of angiogenesis under microflow conditions is a promising alternative to studies on a 2D cell culture [2]. The microsystem consists of two layers. The upper layer contains a mapped network of channels. It is made of PDMS with the use of a micro-milled stamp. The bottom layer (a microscope slide) acts as a seal. The design of the microchip includes three parallel microchannels. Cylindrical microchannels seeded by Human Umbilical Vein Endothelial Cells (HUVECs) were generated using the viscous-finger patterning technique in the two lateral microchannels. Their diameter corresponds to the size of human arteries (701.5 ± 3.1 µm). The ultimate procedure will enable the reconstruction of narrower blood vessels, such as veins and capillaries. The middle microchannel allows for the introduction of a pro-angiogenic factor solution. The influence of Vascular Endothelial Growth Factor (VEGF), with a concentration of 50ng/ml, on the migration of HUVECs was verified. The spatial arrangement of the cells and their morphology was visualized using fluorescence and confocal microscopy. The research conducted so far is the basis for developing more complex vascularized multi-organ-on-a-chip microsystems. Author ContributionsConceptualization, J.K., A.Ż., and E.J.; methodology, J.K., A.Ż., and E.J.; validation, J.K., A.Ż., and E.J.; formal analysis, J.K.; investigation, J.K. and P.S.; data curation, J.K.; writing—original draft preparation, J.K.; writing—review and editing, J.K., A.Ż., and E.J. visualization, J.K.; supervision, A.Ż., and E.J.; project administration, A.Ż., and E.J.; funding acquisition, A.Ż. All authors have read and agreed to the published version of the manuscript.FundingThis research was funded by the National Science Center OPUS No. 2021/41/B/ST4/01725 and BIOTECHMED-3 (Warsaw University of Technology) No. 504/04496/1020/45.010420.Institutional Review Board StatementNot applicable.Informed Consent StatementNot applicable.Data Availability StatementNot applicable.Conflicts of InterestThe authors declare no conflict of interest.ReferencesAspriţoiu, V.M.; Stoica, I.; Bleotu, C.; Diaconu, C.C. Epigenetic Regulation of Angiogenesis in Development and Tumors Progression: Potential Implications for Cancer Treatment. Front. Cell Dev. Biol. 2021, 9, 689962. [Google Scholar] [CrossRef] [PubMed]Moses, S.R.; Adorno, J.J.; Palmer, A.F.; Song, J.W. Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro. Am. J. Physiol. Cell Physiol. 2021, 320, C92–C105. [Google Scholar] [CrossRef] [PubMed]Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Share and Cite MDPI and ACS Style Konopka, J.; Staniszewska, P.; Żuchowska, A.; Jastrzębska, E. A Microsystem for the Study of Vascularization. Eng. Proc. 2022, 21, 50. https://doi.org/10.3390/engproc2022021050 AMA Style Konopka J, Staniszewska P, Żuchowska A, Jastrzębska E. A Microsystem for the Study of Vascularization. Engineering Proceedings. 2022; 21(1):50. https://doi.org/10.3390/engproc2022021050 Chicago/Turabian Style Konopka, Joanna, Patrycja Staniszewska, Agnieszka Żuchowska, and Elżbieta Jastrzębska. 2022. A Microsystem for the Study of Vascularization Engineering Proceedings 21, no. 1: 50. https://doi.org/10.3390/engproc2022021050 Find Other Styles Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here. Article Metrics No No Article Access Statistics Multiple requests from the same IP address are counted as one view." @default.
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