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- W4295113524 abstract "GPR17 is a class A orphan G protein-coupled receptor. The 3.02 Å resolution structure elucidates the activated GPR17 in complex with the Gαi, Gβ, Gγ, and scFv16 in the ligand-free state. The ECL2 of GPR17 occupies the orthosteric binding pocket to promote its self-activation. Meanwhile, the residues D350 and E318 of Gαi form two salt bridges with K3318.49 and R252 of GPR17, respectively, which play a prominent role in the assembly of complex." @default.
- W4295113524 created "2022-09-10" @default.
- W4295113524 date "2022-12-01" @default.
- W4295113524 modified "2023-10-18" @default.
- W4295113524 doi "https://doi.org/10.1002/mco2.v3.4" @default.
- W4295113524 hasPublicationYear "2022" @default.
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