Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295113725> ?p ?o ?g. }
- W4295113725 endingPage "12" @default.
- W4295113725 startingPage "1" @default.
- W4295113725 abstract "Retinopathy of prematurity (ROP) is a major blindness-causing disease that is characterized by an arrest of normal vascular development and neovascularization of the retina. Previous studies have shown that genetic factors may be associated with the development and severity of ROP. However, the genes and mechanisms underlying ROP remain unclear. We aimed to identify hub genes in ROP and drugs related to these genes by integrative analysis. The expression profiles of GSE158799 and GSE135844 were acquired from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were identified. Then, an integrative analysis was performed including Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), gene set enrichment analysis (GSEA), protein-protein interaction (PPI) network, transcription factor (TF)-gene, and miRNA-gene networks analysis. Moreover, we verified hub genes and identified potential drugs. 225 common DEGs were identified. Biological function analysis indicated that angiogenesis, cell surface, cell adhesion, extracellular matrix, and focal adhesion genes were enriched among DEGs. The PI3K/Akt signalingpathway, focal adhesion, and extracellular matrix (ECM)-receptor interaction were markedly enriched in the KEGG pathway analysis. Finally, 5 hub genes related to the nosogenesis of ROP were identified and found to be targeted by VEGFA inhibitors, TLR4 antagonists, and sunitinib. The present study showed that VEGFA, ACTA2, MKI67, CD68, and TLR4 are potential hub genes involved in the pathogenesis of ROP. Moreover, TLR4 antagonists and sunitinib may be new candidate drugs for ROP therapy, in addition to VEGFA inhibitors." @default.
- W4295113725 created "2022-09-10" @default.
- W4295113725 creator A5001091891 @default.
- W4295113725 creator A5003177096 @default.
- W4295113725 creator A5017947172 @default.
- W4295113725 creator A5046561927 @default.
- W4295113725 creator A5065848115 @default.
- W4295113725 creator A5067329294 @default.
- W4295113725 creator A5069352060 @default.
- W4295113725 creator A5069994659 @default.
- W4295113725 date "2022-09-10" @default.
- W4295113725 modified "2023-10-16" @default.
- W4295113725 title "Exploration of Hub Genes in Retinopathy of Prematurity Based on Bioinformatics Analysis of the Oxygen-Induced Retinopathy Model" @default.
- W4295113725 cites W106587198 @default.
- W4295113725 cites W1546661868 @default.
- W4295113725 cites W1552955589 @default.
- W4295113725 cites W1566831845 @default.
- W4295113725 cites W1891377716 @default.
- W4295113725 cites W1968836831 @default.
- W4295113725 cites W1970971784 @default.
- W4295113725 cites W1979726958 @default.
- W4295113725 cites W1982580201 @default.
- W4295113725 cites W2002237351 @default.
- W4295113725 cites W2007763447 @default.
- W4295113725 cites W2011129646 @default.
- W4295113725 cites W2013519546 @default.
- W4295113725 cites W2017745229 @default.
- W4295113725 cites W2034657761 @default.
- W4295113725 cites W2048295473 @default.
- W4295113725 cites W2051190668 @default.
- W4295113725 cites W2068972828 @default.
- W4295113725 cites W2082239238 @default.
- W4295113725 cites W2103017472 @default.
- W4295113725 cites W2104104624 @default.
- W4295113725 cites W2110256992 @default.
- W4295113725 cites W2110304122 @default.
- W4295113725 cites W2113170046 @default.
- W4295113725 cites W2133465414 @default.
- W4295113725 cites W2136878446 @default.
- W4295113725 cites W2145938457 @default.
- W4295113725 cites W2146926183 @default.
- W4295113725 cites W2153646707 @default.
- W4295113725 cites W2167120670 @default.
- W4295113725 cites W2254573998 @default.
- W4295113725 cites W2260107689 @default.
- W4295113725 cites W2420003563 @default.
- W4295113725 cites W2431092830 @default.
- W4295113725 cites W2470526170 @default.
- W4295113725 cites W2525798494 @default.
- W4295113725 cites W2564654074 @default.
- W4295113725 cites W2571062384 @default.
- W4295113725 cites W2593221228 @default.
- W4295113725 cites W2783197533 @default.
- W4295113725 cites W2793752318 @default.
- W4295113725 cites W2801069509 @default.
- W4295113725 cites W2801340054 @default.
- W4295113725 cites W2904246937 @default.
- W4295113725 cites W2916047525 @default.
- W4295113725 cites W2919335410 @default.
- W4295113725 cites W2935842442 @default.
- W4295113725 cites W2936301767 @default.
- W4295113725 cites W2941643041 @default.
- W4295113725 cites W2950753203 @default.
- W4295113725 cites W2954161663 @default.
- W4295113725 cites W2970534831 @default.
- W4295113725 cites W3027857502 @default.
- W4295113725 cites W3041722461 @default.
- W4295113725 cites W3055431151 @default.
- W4295113725 cites W3094960611 @default.
- W4295113725 cites W3109219562 @default.
- W4295113725 cites W3142740835 @default.
- W4295113725 cites W3151209380 @default.
- W4295113725 cites W4251267479 @default.
- W4295113725 doi "https://doi.org/10.1155/2022/9835524" @default.
- W4295113725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36124139" @default.
- W4295113725 hasPublicationYear "2022" @default.
- W4295113725 type Work @default.
- W4295113725 citedByCount "0" @default.
- W4295113725 crossrefType "journal-article" @default.
- W4295113725 hasAuthorship W4295113725A5001091891 @default.
- W4295113725 hasAuthorship W4295113725A5003177096 @default.
- W4295113725 hasAuthorship W4295113725A5017947172 @default.
- W4295113725 hasAuthorship W4295113725A5046561927 @default.
- W4295113725 hasAuthorship W4295113725A5065848115 @default.
- W4295113725 hasAuthorship W4295113725A5067329294 @default.
- W4295113725 hasAuthorship W4295113725A5069352060 @default.
- W4295113725 hasAuthorship W4295113725A5069994659 @default.
- W4295113725 hasBestOaLocation W42951137251 @default.
- W4295113725 hasConcept C104317684 @default.
- W4295113725 hasConcept C150194340 @default.
- W4295113725 hasConcept C152724338 @default.
- W4295113725 hasConcept C162317418 @default.
- W4295113725 hasConcept C2778376644 @default.
- W4295113725 hasConcept C2779234561 @default.
- W4295113725 hasConcept C2779918416 @default.
- W4295113725 hasConcept C54355233 @default.
- W4295113725 hasConcept C60644358 @default.
- W4295113725 hasConcept C70721500 @default.