Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295123865> ?p ?o ?g. }
- W4295123865 abstract "The high recurrence rate of non-muscle invasive bladder cancer (BC) and poor prognosis of advanced BC are therapeutic challenges that need to be solved. Bacillus Calmette-Guerin (BCG) perfusion was the pioneer immunotherapy for early BC, and the discovery of immune checkpoint inhibitors has created a new chapter in the treatment of advanced BC. The benefit of immunotherapy is highly anticipated, but its effectiveness still needs to be improved. In this review, we collated and analysed the currently available information and explored the mechaisms by which the internal immune imbalance of BC leads to tumour progression. The relationship between immunity and progression and the prognosis of BC has been explored through tests using body fluids such as blood and urine. These analytical tests have attempted to identify specific immuyne cells and cytokines to predict treatment outcomes and recurrence. The diversity and proportion of immune and matrix cells in BC determine the heterogeneity and immune status of tumours. The role and classification of immune cells have also been redefined, e.g., CD4 cells having recognised cytotoxicity in BC. Type 2 immunity, including that mediated by M2 macrophages, Th2 cells, and interleukin (IL)-13, plays an important role in the recurrence and progression of BC. Pathological fibrosis, activated by type 2 immunity and cancer cells, enhances the rate of cancer progression and irreversibility. Elucidating the immune status of BC and clarifying the mechanisms of action of different cells in the tumour microenvironment is the research direction to be explored in the future." @default.
- W4295123865 created "2022-09-11" @default.
- W4295123865 creator A5024948361 @default.
- W4295123865 creator A5038669556 @default.
- W4295123865 creator A5051862250 @default.
- W4295123865 creator A5052333619 @default.
- W4295123865 creator A5060059450 @default.
- W4295123865 creator A5073652467 @default.
- W4295123865 creator A5079510247 @default.
- W4295123865 creator A5088672902 @default.
- W4295123865 creator A5091586061 @default.
- W4295123865 date "2022-09-08" @default.
- W4295123865 modified "2023-10-14" @default.
- W4295123865 title "Immune status for monitoring and treatment of bladder cancer" @default.
- W4295123865 cites W1496810310 @default.
- W4295123865 cites W1532624029 @default.
- W4295123865 cites W1538328956 @default.
- W4295123865 cites W1555993773 @default.
- W4295123865 cites W1565267546 @default.
- W4295123865 cites W1577380979 @default.
- W4295123865 cites W1589548603 @default.
- W4295123865 cites W1609688492 @default.
- W4295123865 cites W17446229 @default.
- W4295123865 cites W1763723140 @default.
- W4295123865 cites W1797422316 @default.
- W4295123865 cites W1890550626 @default.
- W4295123865 cites W1921451985 @default.
- W4295123865 cites W1927075449 @default.
- W4295123865 cites W1965038309 @default.
- W4295123865 cites W1966900148 @default.
- W4295123865 cites W1990979240 @default.
- W4295123865 cites W1991480294 @default.
- W4295123865 cites W2002726823 @default.
- W4295123865 cites W2025415116 @default.
- W4295123865 cites W2035660473 @default.
- W4295123865 cites W2037342985 @default.
- W4295123865 cites W2043640405 @default.
- W4295123865 cites W2044835625 @default.
- W4295123865 cites W2046612588 @default.
- W4295123865 cites W2052325011 @default.
- W4295123865 cites W2052960146 @default.
- W4295123865 cites W2055865638 @default.
- W4295123865 cites W2058856567 @default.
- W4295123865 cites W2060469376 @default.
- W4295123865 cites W2066616821 @default.
- W4295123865 cites W2073621589 @default.
- W4295123865 cites W2074546881 @default.
- W4295123865 cites W2079709122 @default.
- W4295123865 cites W2088391932 @default.
- W4295123865 cites W2093773243 @default.
- W4295123865 cites W2093943247 @default.
- W4295123865 cites W2097995306 @default.
- W4295123865 cites W2098958871 @default.
- W4295123865 cites W2099486691 @default.
- W4295123865 cites W2104347254 @default.
- W4295123865 cites W2116554142 @default.
- W4295123865 cites W2118960457 @default.
- W4295123865 cites W2120426523 @default.
- W4295123865 cites W2122415351 @default.
- W4295123865 cites W2132951532 @default.
- W4295123865 cites W2135530652 @default.
- W4295123865 cites W2136964874 @default.
- W4295123865 cites W2137037017 @default.
- W4295123865 cites W2138947021 @default.
- W4295123865 cites W2139606640 @default.
- W4295123865 cites W2142943224 @default.
- W4295123865 cites W2145229182 @default.
- W4295123865 cites W2148463512 @default.
- W4295123865 cites W2151910349 @default.
- W4295123865 cites W2151941382 @default.
- W4295123865 cites W2157923000 @default.
- W4295123865 cites W2158485828 @default.
- W4295123865 cites W2160486077 @default.
- W4295123865 cites W2162166699 @default.
- W4295123865 cites W2166453367 @default.
- W4295123865 cites W2166997969 @default.
- W4295123865 cites W2168909242 @default.
- W4295123865 cites W2198093519 @default.
- W4295123865 cites W2239206886 @default.
- W4295123865 cites W2266280619 @default.
- W4295123865 cites W2277243505 @default.
- W4295123865 cites W2288966509 @default.
- W4295123865 cites W2293531514 @default.
- W4295123865 cites W2301044272 @default.
- W4295123865 cites W2315201381 @default.
- W4295123865 cites W2344330301 @default.
- W4295123865 cites W2395763454 @default.
- W4295123865 cites W2408019246 @default.
- W4295123865 cites W2424595837 @default.
- W4295123865 cites W2512899508 @default.
- W4295123865 cites W2516952220 @default.
- W4295123865 cites W2519423603 @default.
- W4295123865 cites W2527404829 @default.
- W4295123865 cites W2543513026 @default.
- W4295123865 cites W2560367415 @default.
- W4295123865 cites W2572174216 @default.
- W4295123865 cites W2578528809 @default.
- W4295123865 cites W2588916311 @default.
- W4295123865 cites W2590390825 @default.
- W4295123865 cites W2594744108 @default.