Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295123892> ?p ?o ?g. }
- W4295123892 abstract "Human polyomaviruses (HPyVs) can cause serious and deleterious infections in human. Yet, the molecular mechanism underlying these infections, particularly in polyomavirus nephropathy (PVAN), is not well-defined. In the present study, we aimed to identify human genes with codon usage bias (CUB) similar to that of HPyV genes and explore their potential involvement in the pathogenesis of PVAN. The relative synonymous codon usage (RSCU) values of genes of HPyVs and those of human genes were computed and used for Pearson correlation analysis. The involvement of the identified correlation genes in PVAN was analyzed by validating their differential expression in publicly available transcriptomics data. Functional enrichment was performed to uncover the role of sets of genes. The RSCU analysis indicated that the A- and T-ending codons are preferentially used in HPyV genes. In total, 5400 human genes were correlated to the HPyV genes. The protein-protein interaction (PPI) network indicated strong interactions between these proteins. Gene expression analysis indicated that 229 of these genes were consistently and differentially expressed between normal kidney tissues and kidney tissues from PVAN patients. Functional enrichment analysis indicated that these genes were involved in biological processes related to transcription and in pathways related to protein ubiquitination pathway, apoptosis, cellular response to stress, inflammation and immune system. The identified genes may serve as diagnostic biomarkers and potential therapeutic targets for HPyV associated diseases, especially PVAN." @default.
- W4295123892 created "2022-09-11" @default.
- W4295123892 creator A5018748194 @default.
- W4295123892 creator A5030863883 @default.
- W4295123892 creator A5035648948 @default.
- W4295123892 creator A5036144931 @default.
- W4295123892 creator A5064842058 @default.
- W4295123892 creator A5083530167 @default.
- W4295123892 date "2022-09-08" @default.
- W4295123892 modified "2023-09-30" @default.
- W4295123892 title "Human genes with relative synonymous codon usage analogous to that of polyomaviruses are involved in the mechanism of polyomavirus nephropathy" @default.
- W4295123892 cites W1558109577 @default.
- W4295123892 cites W1571058899 @default.
- W4295123892 cites W1930629456 @default.
- W4295123892 cites W1956613997 @default.
- W4295123892 cites W1973704821 @default.
- W4295123892 cites W1985933010 @default.
- W4295123892 cites W2001537500 @default.
- W4295123892 cites W2026614655 @default.
- W4295123892 cites W2027355853 @default.
- W4295123892 cites W2044960379 @default.
- W4295123892 cites W2076157876 @default.
- W4295123892 cites W2085487956 @default.
- W4295123892 cites W2092930500 @default.
- W4295123892 cites W2093263784 @default.
- W4295123892 cites W2115188315 @default.
- W4295123892 cites W2126340442 @default.
- W4295123892 cites W2161944751 @default.
- W4295123892 cites W2317945362 @default.
- W4295123892 cites W2419610621 @default.
- W4295123892 cites W2478931405 @default.
- W4295123892 cites W2479845123 @default.
- W4295123892 cites W2530359606 @default.
- W4295123892 cites W2547419713 @default.
- W4295123892 cites W2563855982 @default.
- W4295123892 cites W2596889385 @default.
- W4295123892 cites W2612936674 @default.
- W4295123892 cites W2765847865 @default.
- W4295123892 cites W2790018205 @default.
- W4295123892 cites W2790136535 @default.
- W4295123892 cites W2793119114 @default.
- W4295123892 cites W2809147071 @default.
- W4295123892 cites W2886412360 @default.
- W4295123892 cites W2888374922 @default.
- W4295123892 cites W2897215926 @default.
- W4295123892 cites W2897587001 @default.
- W4295123892 cites W2898629212 @default.
- W4295123892 cites W2910277232 @default.
- W4295123892 cites W2936246848 @default.
- W4295123892 cites W2941393885 @default.
- W4295123892 cites W2950597272 @default.
- W4295123892 cites W2951444272 @default.
- W4295123892 cites W2951520325 @default.
- W4295123892 cites W2952077983 @default.
- W4295123892 cites W2970998542 @default.
- W4295123892 cites W2983665270 @default.
- W4295123892 cites W2984599362 @default.
- W4295123892 cites W2996163123 @default.
- W4295123892 cites W2998168707 @default.
- W4295123892 cites W3002312612 @default.
- W4295123892 cites W3006262927 @default.
- W4295123892 cites W3009638192 @default.
- W4295123892 cites W3010072924 @default.
- W4295123892 cites W3013843138 @default.
- W4295123892 cites W3023097846 @default.
- W4295123892 cites W3023222607 @default.
- W4295123892 cites W3028313336 @default.
- W4295123892 cites W3039070438 @default.
- W4295123892 cites W3040369347 @default.
- W4295123892 cites W3043958422 @default.
- W4295123892 cites W3046074936 @default.
- W4295123892 cites W3064354475 @default.
- W4295123892 cites W3083874241 @default.
- W4295123892 cites W3088182885 @default.
- W4295123892 cites W3092163145 @default.
- W4295123892 cites W3112164273 @default.
- W4295123892 cites W3114066355 @default.
- W4295123892 cites W3131304542 @default.
- W4295123892 cites W3133744017 @default.
- W4295123892 cites W3135994716 @default.
- W4295123892 cites W3138542051 @default.
- W4295123892 cites W3158720939 @default.
- W4295123892 cites W3160688190 @default.
- W4295123892 cites W3161548327 @default.
- W4295123892 cites W3181602505 @default.
- W4295123892 cites W3189459906 @default.
- W4295123892 cites W3195486386 @default.
- W4295123892 cites W3211618553 @default.
- W4295123892 cites W4211078539 @default.
- W4295123892 cites W4211238524 @default.
- W4295123892 cites W4223509818 @default.
- W4295123892 cites W4226280577 @default.
- W4295123892 cites W2116929605 @default.
- W4295123892 doi "https://doi.org/10.3389/fcimb.2022.992201" @default.
- W4295123892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36159639" @default.
- W4295123892 hasPublicationYear "2022" @default.
- W4295123892 type Work @default.
- W4295123892 citedByCount "0" @default.
- W4295123892 crossrefType "journal-article" @default.
- W4295123892 hasAuthorship W4295123892A5018748194 @default.