Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295126659> ?p ?o ?g. }
- W4295126659 abstract "Abstract Objectives to propose a novel “Skeletal Age” metric as the age of an individual’s skeleton resulting from a fragility fracture to convey the combined risk of fracture and fracture-associated mortality for an individual with specific risk profile. Design a retrospective population-based cohort study. Setting hospital records from the Danish National Hospital Discharge Register that includes the whole-country data of all contacts to health care system. Participants 1,667,339 adults in Denmark born on or before 1 January 1950, who were followed up to 31 December 2016 for incident low-trauma fracture and mortality. Main outcome measures fracture and chronic diseases recorded within 5 years prior to the index fracture were identified using ICD-10 codes. Death was ascertained from the Danish Register on Causes of Death. We used Cox’s proportional hazards regression to estimate the hazard ratio of mortality following a fracture, and then used the Gompertz law of mortality to transform the hazard ratio into life expectancy for a specific fracture site. The difference between life expectancy associated with a fracture and background population life expectancy is regarded as the years of life lost. Skeletal age is then operationally defined as an individual’s current age plus the years of life lost. Results during a median follow-up of 16.0 years, 95,372 men and 212,498 women sustained a fracture, followed by 41,017 and 81,727 deaths, respectively. A fracture was associated with 1 to 4 years of life lost dependent on fracture site, gender and age, with the greater loss being observed in younger men with a hip fracture. Hip, proximal and lower leg fractures, but not distal fractures, were associated with a substantial loss in life expectancy. A 60-year-old man with a hip fracture is expected to have a skeletal age of 66.1 years old (95% CI: 65.9, 66.2). Conclusion we propose to use skeletal age as a metric to assess fracture risk for an individual and thus improve doctor-patient risk communication. What have been known on this topic? Fragility fracture is associated with increased mortality risk, however it is currently underdiagnosed and undermanagement globally. Despite the excess mortality after fracture, mortality is never a part of doctor-patient communication about treatment or risk assessment, due to a lack of an intuitive method of conveying risk as the traditional probability-based risk is counter-intuitive and hard to understand. In engineering, “effective age” is the age of a structure based on its current conditions, and, in medicine, the effective age of an individual is the age of a typical healthy person who matches the specific risk profile of this individual. What this study adds We advanced the concept of “Skeletal Age” as the age of an individual’s skeleton resulting from a fragility fracture using data from a nationwide cohort of 1.7 million adults aged 50+ years old in Denmark. Unlike the existing probability-based risk metrics, skeletal age combines the risk that an individual will sustain a fracture and the risk of mortality once a fracture has occurred, making the doctor-patient communication more intuitive and possibly more effective." @default.
- W4295126659 created "2022-09-11" @default.
- W4295126659 creator A5002099463 @default.
- W4295126659 creator A5003620404 @default.
- W4295126659 creator A5007331364 @default.
- W4295126659 creator A5013196959 @default.
- W4295126659 creator A5032591631 @default.
- W4295126659 creator A5064610994 @default.
- W4295126659 creator A5068483265 @default.
- W4295126659 creator A5071997063 @default.
- W4295126659 date "2022-09-10" @default.
- W4295126659 modified "2023-10-16" @default.
- W4295126659 title "Skeletal Age for mapping the impact of fracture on mortality" @default.
- W4295126659 cites W1511423923 @default.
- W4295126659 cites W1511797896 @default.
- W4295126659 cites W1576707810 @default.
- W4295126659 cites W1659026544 @default.
- W4295126659 cites W1964891491 @default.
- W4295126659 cites W1965454184 @default.
- W4295126659 cites W1972254217 @default.
- W4295126659 cites W1982154330 @default.
- W4295126659 cites W1991234496 @default.
- W4295126659 cites W2012596468 @default.
- W4295126659 cites W2027383875 @default.
- W4295126659 cites W2032821264 @default.
- W4295126659 cites W2045214274 @default.
- W4295126659 cites W2045887406 @default.
- W4295126659 cites W2061450074 @default.
- W4295126659 cites W2067220183 @default.
- W4295126659 cites W2071347566 @default.
- W4295126659 cites W2071677582 @default.
- W4295126659 cites W2079530303 @default.
- W4295126659 cites W2082229075 @default.
- W4295126659 cites W2083754422 @default.
- W4295126659 cites W2100026878 @default.
- W4295126659 cites W2107002319 @default.
- W4295126659 cites W2115856722 @default.
- W4295126659 cites W2116609513 @default.
- W4295126659 cites W2121656227 @default.
- W4295126659 cites W2122235259 @default.
- W4295126659 cites W2125576474 @default.
- W4295126659 cites W2132504853 @default.
- W4295126659 cites W2139796029 @default.
- W4295126659 cites W2155236480 @default.
- W4295126659 cites W2158617468 @default.
- W4295126659 cites W2163830908 @default.
- W4295126659 cites W2168435321 @default.
- W4295126659 cites W2171395152 @default.
- W4295126659 cites W2495406692 @default.
- W4295126659 cites W2594161340 @default.
- W4295126659 cites W2750632486 @default.
- W4295126659 cites W2772055164 @default.
- W4295126659 cites W2783325385 @default.
- W4295126659 cites W2803155890 @default.
- W4295126659 cites W2921015498 @default.
- W4295126659 cites W2970019434 @default.
- W4295126659 cites W3004118886 @default.
- W4295126659 cites W3012640009 @default.
- W4295126659 cites W3018919776 @default.
- W4295126659 cites W3044275622 @default.
- W4295126659 cites W4240668423 @default.
- W4295126659 doi "https://doi.org/10.1101/2022.09.09.22279789" @default.
- W4295126659 hasPublicationYear "2022" @default.
- W4295126659 type Work @default.
- W4295126659 citedByCount "1" @default.
- W4295126659 countsByYear W42951266592023 @default.
- W4295126659 crossrefType "posted-content" @default.
- W4295126659 hasAuthorship W4295126659A5002099463 @default.
- W4295126659 hasAuthorship W4295126659A5003620404 @default.
- W4295126659 hasAuthorship W4295126659A5007331364 @default.
- W4295126659 hasAuthorship W4295126659A5013196959 @default.
- W4295126659 hasAuthorship W4295126659A5032591631 @default.
- W4295126659 hasAuthorship W4295126659A5064610994 @default.
- W4295126659 hasAuthorship W4295126659A5068483265 @default.
- W4295126659 hasAuthorship W4295126659A5071997063 @default.
- W4295126659 hasBestOaLocation W42951266591 @default.
- W4295126659 hasConcept C126322002 @default.
- W4295126659 hasConcept C133925201 @default.
- W4295126659 hasConcept C141071460 @default.
- W4295126659 hasConcept C144024400 @default.
- W4295126659 hasConcept C149923435 @default.
- W4295126659 hasConcept C207103383 @default.
- W4295126659 hasConcept C2908647359 @default.
- W4295126659 hasConcept C44249647 @default.
- W4295126659 hasConcept C50382708 @default.
- W4295126659 hasConcept C71924100 @default.
- W4295126659 hasConcept C72563966 @default.
- W4295126659 hasConcept C74909509 @default.
- W4295126659 hasConcept C99454951 @default.
- W4295126659 hasConceptScore W4295126659C126322002 @default.
- W4295126659 hasConceptScore W4295126659C133925201 @default.
- W4295126659 hasConceptScore W4295126659C141071460 @default.
- W4295126659 hasConceptScore W4295126659C144024400 @default.
- W4295126659 hasConceptScore W4295126659C149923435 @default.
- W4295126659 hasConceptScore W4295126659C207103383 @default.
- W4295126659 hasConceptScore W4295126659C2908647359 @default.
- W4295126659 hasConceptScore W4295126659C44249647 @default.
- W4295126659 hasConceptScore W4295126659C50382708 @default.
- W4295126659 hasConceptScore W4295126659C71924100 @default.
- W4295126659 hasConceptScore W4295126659C72563966 @default.