FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4295128504> ?p ?o ?g. }

• W4295128504 abstract "Abstract A key problem in development is to understand how genes turn on or off at the right place and right time during embryogenesis. Such decisions are made by non-coding sequences called ‘enhancers’. Much of our models of how enhancers work rely on the assumption that genes are activated de novo as stable domains across embryonic tissues. Such view has been strengthened by the intensive landmark studies of the early patterning of the anterior-posterior (AP) axis of the Drosophila embryo, where indeed gene expression domains seem to arise more or less stably. However, careful analysis of gene expressions in other model systems (including the AP patterning in vertebrates and short-germ insects like the beetle Tribolium castaneum ) painted a different, very dynamic view of gene regulation, where genes are oftentimes expressed in a wavelike fashion. How such gene expression waves are mediated at the enhancer level is so far unclear. Here we establish the AP patterning of the short-germ beetle Tribolium as a model system to study dynamic and temporal pattern formation at the enhancer level. To that end, we established an enhancer prediction system in Tribolium based on time- and tissue-specific ATAC-seq and an enhancer live reporter system based on MS2 tagging. Using this experimental framework, we discovered several Tribolium enhancers, and assessed the spatiotemporal activities of some of them in live embryos. We found our data consistent with a model in which the timing of gene expression during embryonic pattern formation is mediated by a balancing act between enhancers that induce rapid changes in gene expressions (that we call ‘dynamic enhancers’) and enhancers that stabilizes gene expressions (that we call ‘static enhancers’)." @default.
• W4295128504 created "2022-09-11" @default.
• W4295128504 creator A5000448200 @default.
• W4295128504 creator A5003321899 @default.
• W4295128504 creator A5013043532 @default.
• W4295128504 creator A5016317172 @default.
• W4295128504 creator A5028945298 @default.
• W4295128504 creator A5053257775 @default.
• W4295128504 creator A5053573640 @default.
• W4295128504 creator A5064145274 @default.
• W4295128504 creator A5085922198 @default.
• W4295128504 date "2022-09-10" @default.
• W4295128504 modified "2023-09-26" @default.
• W4295128504 title "How enhancers regulate wavelike gene expression patterns: Novel enhancer prediction and live reporter systems identify an enhancer associated with the arrest of pair-rule waves in the short-germ beetle<i>Tribolium</i>" @default.
• W4295128504 cites W1276203798 @default.
• W4295128504 cites W1433152810 @default.
• W4295128504 cites W1506197483 @default.
• W4295128504 cites W1531821806 @default.
• W4295128504 cites W1581000258 @default.
• W4295128504 cites W1879564354 @default.
• W4295128504 cites W1964750999 @default.
• W4295128504 cites W1964963969 @default.
• W4295128504 cites W1966683790 @default.
• W4295128504 cites W1976416223 @default.
• W4295128504 cites W1977349921 @default.
• W4295128504 cites W1978798894 @default.
• W4295128504 cites W1979178770 @default.
• W4295128504 cites W1990547217 @default.
• W4295128504 cites W1991138583 @default.
• W4295128504 cites W1991770658 @default.
• W4295128504 cites W1994113364 @default.
• W4295128504 cites W1994245587 @default.
• W4295128504 cites W1996094487 @default.
• W4295128504 cites W1997882261 @default.
• W4295128504 cites W1997902533 @default.
• W4295128504 cites W1998185176 @default.
• W4295128504 cites W1998789624 @default.
• W4295128504 cites W1999668576 @default.
• W4295128504 cites W2004901538 @default.
• W4295128504 cites W2005125317 @default.
• W4295128504 cites W2006223125 @default.
• W4295128504 cites W2014677321 @default.
• W4295128504 cites W2015503950 @default.
• W4295128504 cites W2016015848 @default.
• W4295128504 cites W2017377227 @default.
• W4295128504 cites W2017565236 @default.
• W4295128504 cites W2017800800 @default.
• W4295128504 cites W2021892293 @default.
• W4295128504 cites W2022110934 @default.
• W4295128504 cites W2029669415 @default.
• W4295128504 cites W2031569719 @default.
• W4295128504 cites W2031943513 @default.
• W4295128504 cites W2033904805 @default.
• W4295128504 cites W2034455039 @default.
• W4295128504 cites W2035343693 @default.
• W4295128504 cites W2036897871 @default.
• W4295128504 cites W2039718244 @default.
• W4295128504 cites W2042766832 @default.
• W4295128504 cites W2045362835 @default.
• W4295128504 cites W2047014644 @default.
• W4295128504 cites W2047704995 @default.
• W4295128504 cites W2058816652 @default.
• W4295128504 cites W2061484820 @default.
• W4295128504 cites W2065269256 @default.
• W4295128504 cites W2065528132 @default.
• W4295128504 cites W2065542901 @default.
• W4295128504 cites W2067284166 @default.
• W4295128504 cites W2068962163 @default.
• W4295128504 cites W2074928050 @default.
• W4295128504 cites W2077122170 @default.
• W4295128504 cites W2079721551 @default.
• W4295128504 cites W2083249373 @default.
• W4295128504 cites W2083371883 @default.
• W4295128504 cites W2085405921 @default.
• W4295128504 cites W2087061201 @default.
• W4295128504 cites W2089222127 @default.
• W4295128504 cites W2091439708 @default.
• W4295128504 cites W2091810950 @default.
• W4295128504 cites W2099878990 @default.
• W4295128504 cites W2100898236 @default.
• W4295128504 cites W2102910500 @default.
• W4295128504 cites W2103526067 @default.
• W4295128504 cites W2104235481 @default.
• W4295128504 cites W2107018762 @default.
• W4295128504 cites W2113146724 @default.
• W4295128504 cites W2114104545 @default.
• W4295128504 cites W2115043205 @default.
• W4295128504 cites W2117032951 @default.
• W4295128504 cites W2117104012 @default.
• W4295128504 cites W2117757143 @default.
• W4295128504 cites W2124791602 @default.
• W4295128504 cites W2126153222 @default.
• W4295128504 cites W2126292167 @default.
• W4295128504 cites W2127540003 @default.
• W4295128504 cites W2128043711 @default.
• W4295128504 cites W2128785960 @default.
• W4295128504 cites W2134209896 @default.
• W4295128504 cites W2134510799 @default.
• W4295128504 cites W2135061355 @default.
• W4295128504 cites W2135248498 @default.

• next