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- W4295136150 endingPage "103434" @default.
- W4295136150 startingPage "103434" @default.
- W4295136150 abstract "Morbidity and mortality from diabetes mellitus and associated illnesses is a major problem across the globe. Anti-diabetic medicines must be improved despite existing breakthroughs in treatment approaches. Diabetes has been linked to mitochondrial dysfunction. As a result, particular mitochondrial diabetes kinds like MIDD (maternally inherited diabetes & deafness) and DAD (diabetic autonomic dysfunction) have been identified and studied (diabetes and Deafness). Some mutations as in mitochondrial DNA (mtDNA), that encodes for a significant portion of mitochondrial proteins as well as mitochondrial tRNA essential for mitochondrial protein biosynthesis, are responsible for hereditary mitochondrial diseases. Tissue-specificity and heteroplasmy have a role in the harmful phenotype of mtDNA mutations, making it difficult to generalise findings from one study to another. There are a huge increase in the number for mtDNA mutations related with human illnesses that have been identified using current sequencing technologies. In this study, we make a list on mtDNA mutations linked with diseases and diabetic illnesses and explore the methods by which they contribute to the pathology's emergence." @default.
- W4295136150 created "2022-09-11" @default.
- W4295136150 creator A5029941001 @default.
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- W4295136150 creator A5063394389 @default.
- W4295136150 creator A5080385597 @default.
- W4295136150 creator A5026299438 @default.
- W4295136150 date "2022-12-01" @default.
- W4295136150 modified "2023-09-30" @default.
- W4295136150 title "Role of mitochondrial DNA in diabetes Mellitus Type I and Type II" @default.
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