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- W4295137527 endingPage "112565" @default.
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- W4295137527 abstract "Photochemical instability and reactivity of organic ultraviolet (UV) filters not only degrade the performance of sunscreen formulations but also generate toxic photodegradation products and reactive oxygen species (ROS). Although the encapsulation of organic UV filters into synthetic polymer particles has been widely investigated, synthetic plastics were recently banned for personal care and cosmetic products due to marine and coastal pollution issues. Here we present a plastic-free, photochemically stable and inactive UV filter platform based on chitosan-coated mesoporous silica microparticles, denoted ‘mSOCPs’, incorporating octyl methoxycinnamate (OMC) as a sunscreen agent. Sunlight induced the degradation of ∼80% free OMC in artificial sweat in 1 h at room temperature, while only 20% of OMC degraded for 3 h when encapsulated within mSOCPs. Moreover, mSOCPs efficiently suppressed the photochemical generation of ROS by about 99% through the combined effects of the mesoporous silica structure and chitosan coating. Accordingly, mSOCPs substantially increased the cell viability of fibroblasts exposed to UV irradiation. This work demonstrates that the biopolymer coatings of mesoporous inorganic particles can be a promising approach to the plastic-free encapsulation of organic UV filters for suppressing their photochemical reactivity and degradation." @default.
- W4295137527 created "2022-09-11" @default.
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- W4295137527 date "2022-10-01" @default.
- W4295137527 modified "2023-09-24" @default.
- W4295137527 title "Chitosan-coated mesoporous silica particles as a plastic-free platform for photochemical suppression and stabilization of organic ultraviolet filters" @default.
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- W4295137527 doi "https://doi.org/10.1016/j.jphotobiol.2022.112565" @default.
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