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- W4295138003 abstract "The steroid hormone progesterone (P4), acting via the nuclear P4 receptors (PRs) in uterine cells, is essential for the establishment and maintenance of pregnancy. P4/PR signaling maintains pregnancy by promoting uterine quiescence and blocking the contractions of labor. Withdrawal of the P4/PR block to labor induces parturition. The success of pregnancy requires the timely birth of a mature neonate to a healthy mother, and to this end, the mechanism by which the P4/PR block is withdrawn, and how that process is physiologically controlled is critical. This review examines current understanding of cell and molecular biology of P4/PR withdrawal in the control of parturition." @default.
- W4295138003 created "2022-09-11" @default.
- W4295138003 creator A5084239794 @default.
- W4295138003 date "2022-11-01" @default.
- W4295138003 modified "2023-10-17" @default.
- W4295138003 title "Progesterone withdrawal and parturition" @default.
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- W4295138003 doi "https://doi.org/10.1016/j.jsbmb.2022.106177" @default.
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