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- W4295169098 abstract "Smoking associates with better immune checkpoint inhibitor (ICI) therapy response in patients with advanced non-small cell lung cancer (NSCLC). This may be because smoking correlates with increased tumor mutation burden (TMB), a known ICI response predictor. However, it is unknown whether benefits from smoking are static (i.e., ICI response benefit continues after smoking cessation) or ongoing (i.e., smoking cessation mitigates ICI response benefit). We assess the relationship between TMB and smoking status at initiation of ICI therapy and evaluate how treatment response may vary by TMB and ongoing smoking versus cessation." @default.
- W4295169098 created "2022-09-11" @default.
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- W4295169098 date "2022-09-01" @default.
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- W4295169098 title "EP08.01-045 The Impact of Current Smoking Status at Initiation of Immune Checkpoint Inhibitor Therapy on Tumor Mutation Burden and Survival" @default.
- W4295169098 doi "https://doi.org/10.1016/j.jtho.2022.07.617" @default.
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