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- W4295197831 abstract "Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport. Live cell imaging could provide such mechanistic insights by directly tracking drug transport across intestinal barriers at subcellular resolution, however traditional intestinal in vitro models are not compatible with the necessary live cell imaging modalities. Here, we employed a novel microfluidic platform to develop an in vitro intestinal epithelial barrier compatible with advanced widefield- and confocal microscopy. We established a quantitative, multiplexed and high-temporal resolution imaging assay for investigating the cellular uptake and cross-barrier transport of biologics while simultaneously monitoring barrier integrity. As a proof-of-principle, we use the generic model to monitor the transport of co-administrated cell penetrating peptide (TAT) and insulin. We show that while TAT displayed a concentration dependent difference in its transport mechanism and efficiency, insulin displayed cellular internalization, but was restricted from transport across the barrier. This illustrates how such a sophisticated imaging based barrier model can facilitate mechanistic studies of drug transport across intestinal barriers and aid in vivo and clinical translation in drug development." @default.
- W4295197831 created "2022-09-12" @default.
- W4295197831 creator A5000022310 @default.
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- W4295197831 creator A5090237640 @default.
- W4295197831 date "2022-09-09" @default.
- W4295197831 modified "2023-10-10" @default.
- W4295197831 title "Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging" @default.
- W4295197831 cites W1498305210 @default.
- W4295197831 cites W1760590176 @default.
- W4295197831 cites W1872647657 @default.
- W4295197831 cites W1904678284 @default.
- W4295197831 cites W1939160085 @default.
- W4295197831 cites W1965082410 @default.
- W4295197831 cites W1965712862 @default.
- W4295197831 cites W1965884363 @default.
- W4295197831 cites W1973488401 @default.
- W4295197831 cites W1979196526 @default.
- W4295197831 cites W1979665070 @default.
- W4295197831 cites W1995961820 @default.
- W4295197831 cites W2003110090 @default.
- W4295197831 cites W2008663740 @default.
- W4295197831 cites W2011739832 @default.
- W4295197831 cites W2012906994 @default.
- W4295197831 cites W2013735026 @default.
- W4295197831 cites W2025536728 @default.
- W4295197831 cites W2034879954 @default.
- W4295197831 cites W2037029956 @default.
- W4295197831 cites W2038299379 @default.
- W4295197831 cites W2039099865 @default.
- W4295197831 cites W2039693707 @default.
- W4295197831 cites W2041454039 @default.
- W4295197831 cites W2041802266 @default.
- W4295197831 cites W2058732924 @default.
- W4295197831 cites W2062253976 @default.
- W4295197831 cites W2063115767 @default.
- W4295197831 cites W2066872936 @default.
- W4295197831 cites W2067438336 @default.
- W4295197831 cites W2070380977 @default.
- W4295197831 cites W2077767091 @default.
- W4295197831 cites W2079197876 @default.
- W4295197831 cites W2079335891 @default.
- W4295197831 cites W2089657872 @default.
- W4295197831 cites W2094895270 @default.
- W4295197831 cites W2100114021 @default.
- W4295197831 cites W2102125805 @default.
- W4295197831 cites W2105865453 @default.
- W4295197831 cites W2109357680 @default.
- W4295197831 cites W2120442500 @default.
- W4295197831 cites W2125450037 @default.
- W4295197831 cites W2133750711 @default.
- W4295197831 cites W2154555351 @default.
- W4295197831 cites W2160863389 @default.
- W4295197831 cites W2164059729 @default.
- W4295197831 cites W2166073285 @default.
- W4295197831 cites W2167051532 @default.
- W4295197831 cites W2168752825 @default.
- W4295197831 cites W2206619362 @default.
- W4295197831 cites W2289304655 @default.
- W4295197831 cites W2504159933 @default.
- W4295197831 cites W2516258544 @default.
- W4295197831 cites W255170080 @default.
- W4295197831 cites W2577145949 @default.
- W4295197831 cites W2583937133 @default.
- W4295197831 cites W2742210001 @default.
- W4295197831 cites W2793785550 @default.
- W4295197831 cites W2799449856 @default.
- W4295197831 cites W2801697793 @default.
- W4295197831 cites W2806014665 @default.
- W4295197831 cites W2901306081 @default.
- W4295197831 cites W2909235595 @default.
- W4295197831 cites W2919899673 @default.
- W4295197831 cites W2969106555 @default.
- W4295197831 cites W2980533651 @default.
- W4295197831 cites W2985650421 @default.
- W4295197831 cites W2996266725 @default.
- W4295197831 cites W2998069424 @default.
- W4295197831 cites W3001831828 @default.
- W4295197831 cites W3005027548 @default.
- W4295197831 cites W3018571601 @default.
- W4295197831 cites W3023166894 @default.
- W4295197831 cites W3030007836 @default.
- W4295197831 cites W3037673643 @default.
- W4295197831 cites W3040213586 @default.
- W4295197831 cites W3042632143 @default.
- W4295197831 cites W3045002826 @default.
- W4295197831 cites W3087369767 @default.
- W4295197831 cites W3112220264 @default.
- W4295197831 cites W3167165345 @default.
- W4295197831 cites W3170536526 @default.
- W4295197831 cites W3195991104 @default.
- W4295197831 cites W4214884829 @default.
- W4295197831 cites W4232529163 @default.